33 items (Lipotes vexillifer) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CALR	Calreticulin. (415 aa)
	ZMIZ1	Zinc finger MIZ domain-containing protein 1. (1065 aa)
	SMC6	Structural maintenance of chromosomes protein 6. (1097 aa)
	LOC103084351	LOW QUALITY PROTEIN: T-box transcription factor TBX3-like. (737 aa)
	TBX2	T-box transcription factor TBX2. (875 aa)
	BRCA2	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
	NUP62	Nuclear pore glycoprotein p62. (516 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	OPA1	LOW QUALITY PROTEIN: dynamin-like 120 kDa protein, mitochondrial; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1088 aa)
	ID2	DNA-binding protein inhibitor ID-2. (134 aa)
	LOC103074699	Augurin. (151 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
	SIRT1	LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1. (695 aa)
	NSMCE2	E3 SUMO-protein ligase NSE2. (246 aa)
	SRF	Serum response factor. (510 aa)
	LMNA	prelamin-A/C isoform X1; Belongs to the intermediate filament family. (664 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2087 aa)
	LOC103085427	Nuclear pore glycoprotein p62-like. (328 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
	MNT	Max-binding protein MNT. (575 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
	PRELP	Prolargin. (379 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
	WRN	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa)
	PML	Protein PML. (848 aa)
	PLA2R1	LOW QUALITY PROTEIN: secretory phospholipase A2 receptor. (1379 aa)
	ABL1	Tyrosine-protein kinase. (1006 aa)
	MAPKAPK5	MAP kinase-activated protein kinase 5 isoform X1. (473 aa)
	HMGA2	High mobility group protein HMGI-C. (109 aa)
	LOC103070587	Tyrosine-protein kinase ABL1-like. (126 aa)
	SMC5	Structural maintenance of chromosomes protein 5. (1106 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	HRAS	A0A340WVZ5	A0A340Y3B4	Tyrosine-protein kinase.	GTPase HRas isoform X1.	0.403
ABL1	TP53	A0A340WVZ5	A0A340XCN5	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.479
BRCA2	TP53	A0A340XSP0	A0A340XCN5	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.890
BRCA2	TP63	A0A340XSP0	A0A340XGH2	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.406
BRCA2	WRN	A0A340XSP0	A0A340WKW9	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.	0.932
CDKN1A	SIRT1	A0A340Y751	A0A340XBY0	Cyclin-dependent kinase inhibitor 1 isoform X1.	LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1.	0.533
CDKN1A	TP53	A0A340Y751	A0A340XCN5	Cyclin-dependent kinase inhibitor 1 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.995
HMGA2	TP53	A0A340WD20	A0A340XCN5	High mobility group protein HMGI-C.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.441
HRAS	ABL1	A0A340Y3B4	A0A340WVZ5	GTPase HRas isoform X1.	Tyrosine-protein kinase.	0.403
HRAS	LOC103070587	A0A340Y3B4	A0A340WDD9	GTPase HRas isoform X1.	Tyrosine-protein kinase ABL1-like.	0.403
HRAS	MAP2K1	A0A340Y3B4	A0A340WM60	GTPase HRas isoform X1.	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily.	0.961
HRAS	PRKCD	A0A340Y3B4	A0A340WCL0	GTPase HRas isoform X1.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.430
HRAS	TP53	A0A340Y3B4	A0A340XCN5	GTPase HRas isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.640
KAT6A	PML	A0A340X8J3	A0A340WI78	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Protein PML.	0.539
KAT6A	SIRT1	A0A340X8J3	A0A340XBY0	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1.	0.474
KAT6A	TP53	A0A340X8J3	A0A340XCN5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.523
KAT6A	WRN	A0A340X8J3	A0A340WKW9	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase.	0.680
LMNA	SIRT1	A0A340X8R2	A0A340XBY0	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1.	0.471
LMNA	TP53	A0A340X8R2	A0A340XCN5	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.488
LOC103070587	HRAS	A0A340WDD9	A0A340Y3B4	Tyrosine-protein kinase ABL1-like.	GTPase HRas isoform X1.	0.403