STRINGSTRING
CACNA1E CACNA1E HTR2C HTR2C SCN1A SCN1A SCN8A SCN8A PKD2 PKD2 PAWR PAWR CACNA1F CACNA1F RYR2 RYR2 TRPV3 TRPV3 PLCG2 PLCG2 ITPR3 ITPR3 MCOLN1 MCOLN1 LOC103080144 LOC103080144 TMEM38A TMEM38A TMEM38B TMEM38B HTR2A HTR2A TRPV5 TRPV5 DDIT3 DDIT3 LETM1 LETM1 SCN5A SCN5A TPCN2 TPCN2 TRPV6 TRPV6 SCN11A SCN11A GP1BB GP1BB CACNA1C CACNA1C GPR98 GPR98 SLC24A2 SLC24A2 SLC8B1 SLC8B1 FGF2 FGF2 FAM155B FAM155B TPCN1 TPCN1 LOC103089149 LOC103089149 RYR1 RYR1 CCR5 CCR5 XCR1 XCR1 CCL21 CCL21 CCL19 CCL19 CCL3 CCL3 CACNA1S CACNA1S GRIN2C GRIN2C ITPR1 ITPR1 HTR2B HTR2B LOC103069848 LOC103069848 PTPRC PTPRC TRPV4 TRPV4 SLC8A1 SLC8A1 ERO1L ERO1L IBTK IBTK ITPR2 ITPR2 FASLG FASLG P2RX7 P2RX7 CACNA1D CACNA1D SCN9A SCN9A CHERP CHERP TRPV1 TRPV1 SLC24A4 SLC24A4 TRPM2 TRPM2 GRIN2B GRIN2B GP9 GP9 TRPM1 TRPM1 SLC8A3 SLC8A3 FKBP1B FKBP1B MCOLN2 MCOLN2 SLC8A2 SLC8A2 BBC3 BBC3 MCOLN3 MCOLN3 NOL3 NOL3 GP1BA GP1BA CACNA1G CACNA1G BCL2 BCL2 TRPV2 TRPV2 GRIN2A GRIN2A FAM155A FAM155A RYR3 RYR3 F2R F2R GRIN2D GRIN2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2314 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1994 aa)
PKD2LOW QUALITY PROTEIN: polycystin-2. (963 aa)
PAWRLOW QUALITY PROTEIN: PRKC apoptosis WT1 regulator protein. (343 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1976 aa)
RYR2Ryanodine receptor 2-like. (4986 aa)
TRPV3LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (789 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
MCOLN1Mucolipin-1 isoform X1. (580 aa)
LOC103080144Sodium/calcium exchanger 3-like; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (595 aa)
TMEM38ATrimeric intracellular cation channel type A. (299 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (731 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LETM1LETM1 and EF-hand domain-containing protein 1, mitochondrial. (908 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2020 aa)
TPCN2Two pore calcium channel protein 2. (758 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (721 aa)
SCN11ASodium channel protein type 11 subunit alpha. (1442 aa)
GP1BBPlatelet glycoprotein Ib beta chain. (205 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2112 aa)
GPR98G-protein coupled receptor 98. (5735 aa)
SLC24A2Sodium/potassium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (662 aa)
SLC8B1Sodium/potassium/calcium exchanger 6, mitochondrial isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (600 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
FAM155BLOW QUALITY PROTEIN: transmembrane protein FAM155B. (471 aa)
TPCN1Two pore calcium channel protein 1 isoform X1. (817 aa)
LOC103089149G-protein coupled receptor 98-like; Belongs to the G-protein coupled receptor 2 family. (702 aa)
RYR1Ryanodine receptor 1 isoform X2. (5032 aa)
CCR5c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CCL21c-C motif chemokine 21. (131 aa)
CCL19C-C motif chemokine. (100 aa)
CCL3LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3. (88 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C. (1201 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1121 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (863 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
ERO1LERO1-like protein alpha. (468 aa)
IBTKLOW QUALITY PROTEIN: inhibitor of Bruton tyrosine kinase. (1360 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1987 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (913 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (837 aa)
SLC24A4Sodium/potassium/calcium exchanger 4 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (618 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1496 aa)
GP9Platelet glycoprotein IX. (177 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1699 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (304 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
MCOLN2Mucolipin-2. (566 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
BBC3Bcl-2-binding component 3. (193 aa)
MCOLN3Mucolipin-3 isoform X1. (552 aa)
NOL3Nucleolar protein 3. (202 aa)
GP1BAPlatelet glycoprotein Ib alpha chain. (584 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2389 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (761 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1464 aa)
FAM155ATransmembrane protein FAM155A. (553 aa)
RYR3Ryanodine receptor 3. (4869 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (428 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (1334 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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