(22 nodes) Integral component of presynaptic membrane network (Lipotes vexillifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADAM23	Disintegrin and metalloproteinase domain-containing protein 23. (833 aa)
	SLC1A2	Amino acid transporter. (565 aa)
	GRM3	Metabotropic glutamate receptor 3 isoform X1. (879 aa)
	CADM3	Cell adhesion molecule 3-like. (409 aa)
	NPTN	Neuroplastin isoform X1. (398 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
	GRIK4	Glutamate receptor ionotropic, kainate 4. (919 aa)
	PRRT2	LOW QUALITY PROTEIN: proline-rich transmembrane protein 2. (411 aa)
	DRD2	D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	CDH2	Cadherin-2 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	FXYD6	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (143 aa)
	EFNB3	LOW QUALITY PROTEIN: ephrin-B3; Belongs to the ephrin family. (356 aa)
	EPHB2	Ephrin type-B receptor 2 isoform X1. (964 aa)
	KCNJ9	LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 3. (469 aa)
	PTPRS	Receptor-type tyrosine-protein phosphatase S isoform X2. (1948 aa)
	LOC103079052	LOW QUALITY PROTEIN: protocadherin-17-like. (1167 aa)
	KCNJ3	G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
	EPHA4	Ephrin type-A receptor 4-like isoform X1. (986 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1308 aa)
	CNR1	Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
	LRFN3	Leucine-rich repeat and fibronectin type-III domain-containing protein 3. (628 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY8	CNR1	A0A340WM11	A0A340YGI7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...]	0.911
CNR1	ADCY8	A0A340YGI7	A0A340WM11	Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...]	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.911
EFNB3	EPHA4	A0A340XCP0	A0A340Y2C3	LOW QUALITY PROTEIN: ephrin-B3; Belongs to the ephrin family.	Ephrin type-A receptor 4-like isoform X1.	0.934
EFNB3	EPHB2	A0A340XCP0	A0A340XJ06	LOW QUALITY PROTEIN: ephrin-B3; Belongs to the ephrin family.	Ephrin type-B receptor 2 isoform X1.	0.990
EPHA4	EFNB3	A0A340Y2C3	A0A340XCP0	Ephrin type-A receptor 4-like isoform X1.	LOW QUALITY PROTEIN: ephrin-B3; Belongs to the ephrin family.	0.934
EPHA4	EPHB2	A0A340Y2C3	A0A340XJ06	Ephrin type-A receptor 4-like isoform X1.	Ephrin type-B receptor 2 isoform X1.	0.528
EPHB2	EFNB3	A0A340XJ06	A0A340XCP0	Ephrin type-B receptor 2 isoform X1.	LOW QUALITY PROTEIN: ephrin-B3; Belongs to the ephrin family.	0.990
EPHB2	EPHA4	A0A340XJ06	A0A340Y2C3	Ephrin type-B receptor 2 isoform X1.	Ephrin type-A receptor 4-like isoform X1.	0.528
KCNJ3	KCNJ9	A0A340Y0X7	A0A340XL42	G protein-activated inward rectifier potassium channel 1 isoform X1.	LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 3.	0.618
KCNJ9	KCNJ3	A0A340XL42	A0A340Y0X7	LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 3.	G protein-activated inward rectifier potassium channel 1 isoform X1.	0.618
LRFN3	PTPRS	A0A340YI32	A0A340XMU3	Leucine-rich repeat and fibronectin type-III domain-containing protein 3.	Receptor-type tyrosine-protein phosphatase S isoform X2.	0.577
PTPRS	LRFN3	A0A340XMU3	A0A340YI32	Receptor-type tyrosine-protein phosphatase S isoform X2.	Leucine-rich repeat and fibronectin type-III domain-containing protein 3.	0.577