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| | POLQ | LOW QUALITY PROTEIN: DNA polymerase theta. (2603 aa) |
| | CECR2 | LOW QUALITY PROTEIN: cat eye syndrome chromosome region, candidate 2. (1214 aa) |
| | TDP1 | tyrosyl-DNA phosphodiesterase 1. (603 aa) |
| | DHX36 | Probable ATP-dependent RNA helicase DHX36 isoform X1. (1014 aa) |
| | HLTF | Helicase-like transcription factor. (1010 aa) |
| | TREX1 | LOW QUALITY PROTEIN: three prime repair exonuclease 1. (368 aa) |
| | MSH3 | DNA mismatch repair protein Msh3-like. (620 aa) |
| | LOC103068511 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (387 aa) |
| | CHD7 | chromodomain-helicase-DNA-binding protein 7. (2305 aa) |
| | LOC103070901 | Uncharacterized protein LOC103070901. (289 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1430 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | EXO5 | LOW QUALITY PROTEIN: exonuclease 5. (372 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1127 aa) |
| | DCLRE1A | DNA cross-link repair 1A protein. (1054 aa) |
| | NEIL2 | Endonuclease 8-like 2. (338 aa) |
| | ENDOG | Endonuclease. (296 aa) |
| | LOC103082188 | Putative ATP-dependent RNA helicase DDX11-like protein 8-like isoform X1. (906 aa) |
| | CHD4 | chromodomain-helicase-DNA-binding protein 4. (1912 aa) |
| | POLI | DNA polymerase iota. (728 aa) |
| | LOC103075047 | LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 1-like. (1710 aa) |
| | CEP41 | Centrosomal protein of 41 kDa isoform X1. (373 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | DDX1 | ATP-dependent RNA helicase DDX1 isoform X1. (740 aa) |
| | XRCC2 | DNA repair protein XRCC2-like. (280 aa) |
| | RFC2 | Replication factor C subunit 2 isoform X1. (352 aa) |
| | POLG | LOW QUALITY PROTEIN: DNA polymerase subunit gamma-1. (1230 aa) |
| | LOC103081657 | Activating signal cointegrator 1 complex subunit 3-like. (2201 aa) |
| | DNASE2 | LOW QUALITY PROTEIN: deoxyribonuclease-2-alpha. (378 aa) |
| | LOC103089678 | Twinkle protein, mitochondrial. (684 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | ALKBH4 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4. (302 aa) |
| | RBBP4 | Histone-binding protein RBBP4 isoform X1. (425 aa) |
| | LOC103091337 | ATPase WRNIP1 homolog C26H5.02c-like. (412 aa) |
| | SMUG1 | Single-strand selective monofunctional uracil DNA glycosylase. (271 aa) |
| | LOC103080655 | chromodomain-helicase-DNA-binding protein 7-like. (414 aa) |
| | MCM8 | DNA helicase MCM8 isoform X1; Belongs to the MCM family. (832 aa) |
| | FANCM | LOW QUALITY PROTEIN: Fanconi anemia group M protein. (2076 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (304 aa) |
| | LOC103074383 | DNA topoisomerase 2-beta-like. (371 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa) |
| | HFM1 | Probable ATP-dependent DNA helicase HFM1. (1435 aa) |
| | SMARCA2 | Probable global transcription activator SNF2L2-like isoform X1. (1559 aa) |
| | TM4SF19 | Transmembrane 4 L6 family member 19. (333 aa) |
| | ERCC6L | DNA excision repair protein ERCC-6-like isoform X1. (1247 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1615 aa) |
| | DKC1 | H/ACA ribonucleoprotein complex subunit 4. (420 aa) |
| | LOC103072432 | Uncharacterized protein FLJ43738-like. (515 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (991 aa) |
| | IGHMBP2 | DNA-binding protein SMUBP-2. (982 aa) |
| | APTX | Aprataxin isoform X1. (347 aa) |
| | LOC103081163 | Nucleoside diphosphate kinase. (152 aa) |
| | BRIP1 | LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1241 aa) |
| | GTF2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1224 aa) |
| | PRIMPOL | DNA-directed primase/polymerase protein. (555 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like isoform X1. (756 aa) |
| | CHD6 | chromodomain-helicase-DNA-binding protein 6 isoform X1. (2720 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (769 aa) |
| | FBXO18 | F-box only protein 18 isoform X1. (978 aa) |
| | KIAA1257 | Uncharacterized protein KIAA1257 homolog. (407 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | APLF | Aprataxin and PNK-like factor. (511 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1533 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5. (733 aa) |
| | LOC103072159 | Uncharacterized protein C17orf64 homolog. (236 aa) |
| | PMS1 | PMS1 protein homolog 1. (932 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | GEN1 | Flap endonuclease GEN homolog 1. (905 aa) |
| | DCLRE1B | 5' exonuclease Apollo. (539 aa) |
| | LIG1 | DNA ligase. (921 aa) |
| | ENDOV | Endonuclease V. (314 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1249 aa) |
| | LOC103071128 | Uncharacterized protein. (579 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (865 aa) |
| | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3. (1078 aa) |
| | SMARCA5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1052 aa) |
| | SMARCAL1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (951 aa) |
| | EP400 | E1A-binding protein p400. (3065 aa) |
| | ERCC5 | DNA repair protein complementing XP-G cells. (1201 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (320 aa) |
| | TEP1 | Telomerase protein component 1 isoform X1. (2626 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain-containing protein 1 isoform X1. (659 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa) |
| | TTF2 | Transcription termination factor 2. (1165 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (570 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (916 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1615 aa) |
| | MLH1 | DNA mismatch repair protein Mlh1 isoform X1. (757 aa) |
| | EXOG | Nuclease EXOG, mitochondrial. (368 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | UPF1 | Regulator of nonsense transcripts 1. (1110 aa) |
| | DCLRE1C | Protein artemis. (710 aa) |
| | MUS81 | Crossover junction endonuclease MUS81. (551 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (341 aa) |
| | POLK | DNA polymerase kappa. (885 aa) |
| | CHD9 | LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 9. (2887 aa) |
| | DQX1 | ATP-dependent RNA helicase DQX1 isoform X1. (719 aa) |
| | BIVM | Basic immunoglobulin-like variable motif-containing protein isoform X1. (504 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1312 aa) |
| | ERCC3 | TFIIH basal transcription factor complex helicase XPB subunit. (782 aa) |
| | MLH3 | DNA mismatch repair protein Mlh3. (1453 aa) |
| | LOC103085993 | hemK methyltransferase family member 2-like. (210 aa) |
| | ERCC2 | TFIIH basal transcription factor complex helicase XPD subunit isoform X1. (760 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1 isoform X1. (294 aa) |
| | MSH5 | mutS protein homolog 5 isoform X1. (832 aa) |
| | FTO | Alpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa) |
| | SMARCA4 | Transcription activator BRG1. (1619 aa) |
| | CHD1L | chromodomain-helicase-DNA-binding protein 1-like isoform X1. (899 aa) |
| | INO80 | DNA helicase INO80. (1564 aa) |
| | NAV2 | Neuron navigator 2 isoform X2. (2410 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | ALKBH1 | LOW QUALITY PROTEIN: alkylated DNA repair protein alkB homolog 1. (389 aa) |
| | POLH | DNA polymerase eta isoform X1. (803 aa) |
| | LOC103083593 | Ras GTPase-activating protein-binding protein 1-like. (286 aa) |
| | POLG2 | DNA polymerase subunit gamma-2, mitochondrial. (482 aa) |
| | METTL4 | Methyltransferase-like protein 4; Belongs to the MT-A70-like family. (470 aa) |
| | TREX2 | Three prime repair exonuclease 2. (78 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa) |
| | DNASE1L1 | Deoxyribonuclease-1-like 1. (433 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | PLD3 | Phospholipase D3 isoform X1. (490 aa) |
| | DNASE2B | Deoxyribonuclease-2-beta isoform X1. (357 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa) |
| | TATDN1 | Putative deoxyribonuclease TATDN1. (296 aa) |
| | XRCC1 | DNA repair protein XRCC1. (628 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (709 aa) |
| | ALKBH3 | LOW QUALITY PROTEIN: alpha-ketoglutarate-dependent dioxygenase alkB homolog 3. (286 aa) |
| | BPTF | Nucleosome-remodeling factor subunit BPTF isoform X1. (2773 aa) |
| | XRCC3 | DNA repair protein XRCC3. (346 aa) |
| | CHD3 | chromodomain-helicase-DNA-binding protein 3. (1986 aa) |
| | LOC103077720 | DNA (Cytosine-5)-methyltransferase 3A-like isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (723 aa) |
| | RSF1 | LOW QUALITY PROTEIN: remodeling and spacing factor 1. (1440 aa) |
| | CDK7 | Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (353 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | TDP2 | tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1024 aa) |
| | MCM9 | DNA helicase MCM9; Belongs to the MCM family. (1144 aa) |
| | LOC103078373 | ATP-dependent DNA helicase srs2-like. (625 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa) |
| | MPG | DNA-3-methyladenine glycosylase. (277 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform X1. (471 aa) |
| | RAD54B | DNA repair and recombination protein RAD54B isoform X1. (909 aa) |
| | SUB1 | Activated RNA polymerase II transcriptional coactivator p15. (127 aa) |
| | LOC103077456 | DNA (Cytosine-5)-methyltransferase 3A-like. (165 aa) |
| | DNASE1L2 | LOW QUALITY PROTEIN: deoxyribonuclease-1-like 2. (396 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (271 aa) |
| | SRCAP | Helicase SRCAP-like. (3241 aa) |
| | DNASE1 | Deoxyribonuclease; Belongs to the DNase I family. (284 aa) |
| | ATAD5 | LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5. (1898 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (988 aa) |
| | SUPV3L1 | LOW QUALITY PROTEIN: ATP-dependent RNA helicase SUPV3L1, mitochondrial. (785 aa) |
| | TDG | G/T mismatch-specific thymine DNA glycosylase isoform X1. (405 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (829 aa) |
| | XRCC6 | X-ray repair cross-complementing protein 6 isoform X1. (609 aa) |
| | LOC103071096 | DNA mismatch repair protein Msh3-like. (511 aa) |
| | LOC103074970 | Probable DNA gyrase subunit A, chloroplastic/mitochondrial-like. (985 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa) |
| | DMC1 | Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (340 aa) |
| | REV3L | DNA polymerase zeta catalytic subunit isoform X1. (3133 aa) |
| | DSCC1 | Sister chromatid cohesion protein DCC1. (392 aa) |
| | CHTF18 | Chromosome transmission fidelity protein 18 homolog. (978 aa) |
| | OGG1 | LOW QUALITY PROTEIN: N-glycosylase/DNA lyase. (318 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (304 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | CHD5 | chromodomain-helicase-DNA-binding protein 5. (1817 aa) |
| | PGBD5 | piggyBac transposable element-derived protein 5. (409 aa) |
| | MUTYH | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (524 aa) |
| | SMARCA1 | Probable global transcription activator SNF2L1 isoform X1. (1070 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | WRNIP1 | ATPase WRNIP1 isoform X1. (637 aa) |
| | DHX9 | ATP-dependent RNA helicase A. (1253 aa) |
| | SMARCAD1 | annotation not available (1028 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | RAD54L2 | Helicase ARIP4 isoform X1. (1465 aa) |
| | POLN | DNA polymerase nu-like. (579 aa) |
| | REXO2 | Oligoribonuclease, mitochondrial. (237 aa) |
| | MRE11A | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | SHPRH | E3 ubiquitin-protein ligase SHPRH isoform X1. (1684 aa) |
| | SPO11 | Meiotic recombination protein SPO11 isoform X1. (395 aa) |
| | LOC103077896 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (386 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (539 aa) |
| | HAUS3 | HAUS augmin-like complex subunit 3. (603 aa) |
| | DFFB | DNAation factor subunit beta. (341 aa) |
| | RAD51B | DNA repair protein RAD51 homolog 2. (252 aa) |
| | LOC103084651 | ATP-dependent DNA helicase srs2-like. (707 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (648 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa) |
| | LOC103084372 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (634 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2. (865 aa) |
| | ALKBH2 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform X1. (260 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (312 aa) |
| | CHD2 | chromodomain-helicase-DNA-binding protein 2. (1806 aa) |
| | RFC1 | Replication factor C subunit 1. (1245 aa) |
| | ERCC6L2 | Putative DNA repair and recombination protein RAD26 isoform X1. (1562 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa) |
| | LOC103068304 | Uncharacterized protein LOC103068304. (205 aa) |
| | HELQ | LOW QUALITY PROTEIN: helicase POLQ-like. (1118 aa) |
| | RAD51C | DNA repair protein RAD51 homolog 3. (337 aa) |
| | LOC103081631 | Activating signal cointegrator 1 complex subunit 3-like. (274 aa) |
| | DICER1 | LOW QUALITY PROTEIN: endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9 isoform X1. (1180 aa) |
| | ATRX | Transcriptional regulator ATRX. (2485 aa) |
| | LOC103076219 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | G3BP1 | Ras GTPase-activating protein-binding protein 1. (465 aa) |
| | ERCC6 | DNA excision repair protein ERCC-6. (1485 aa) |
| | RAD51D | DNA repair protein RAD51 homolog 4. (350 aa) |
| | POLA1 | DNA polymerase. (1462 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (892 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) |
| | LOC103074354 | Probable DNA-3-methyladenine glycosylase-like. (203 aa) |
| | ACACB | acetyl-CoA carboxylase 2. (2457 aa) |
| | ISG20 | Interferon-stimulated gene 20 kDa protein. (171 aa) |
| | SMC5 | Structural maintenance of chromosomes protein 5. (1106 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (550 aa) |
| | DNMT3B | DNA (Cytosine-5)-methyltransferase 3B isoform X2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (856 aa) |
| | NEIL1 | Endonuclease 8-like 1. (390 aa) |
| | LIG3 | DNA ligase. (1013 aa) |
| | HELB | DNA helicase B. (1077 aa) |
| | HMGA2 | High mobility group protein HMGI-C. (109 aa) |
| | MSH4 | mutS protein homolog 4. (934 aa) |
| | NEIL3 | Endonuclease 8-like 3. (606 aa) |
