STRINGSTRING
GRB2 GRB2 MGARP MGARP ZFP36L1 ZFP36L1 PIK3R1 PIK3R1 LPIN1 LPIN1 AKT1 AKT1 LGMN LGMN EPRS EPRS NDEL1 NDEL1 INSIG2 INSIG2 ARHGEF2 ARHGEF2 RAB13 RAB13 PKLR PKLR STAT6 STAT6 LOC103075410 LOC103075410 PARP6 PARP6 SOCS2 SOCS2 CACNA2D1 CACNA2D1 USF1 USF1 INS INS CRHR2 CRHR2 TIMELESS TIMELESS RB1 RB1 IRS1 IRS1 BCAR3 BCAR3 EPHA4 EPHA4 GHRHR GHRHR GPER1 GPER1 CACNB1 CACNB1 PCSK9 PCSK9 SLC2A8 SLC2A8 FOXO1 FOXO1 POU4F2 POU4F2 TSHR TSHR SLC27A4 SLC27A4 DNAI1 DNAI1 KAT2B KAT2B RAB10 RAB10 GOT1 GOT1 EDNRA EDNRA CRHBP CRHBP DENND4C DENND4C INHBB INHBB FOXO4 FOXO4 CACNA1A CACNA1A RARRES2 RARRES2 SH2B2 SH2B2 GPR21 GPR21 CAPN10 CAPN10 ZDHHC7 ZDHHC7 LEP LEP IGF1R IGF1R NR4A2 NR4A2 PDK2 PDK2 CHMP5 CHMP5 LPIN3 LPIN3 PARP1 PARP1 PRKDC PRKDC PRNP PRNP LOC103078777 LOC103078777 AGTR2 AGTR2 PTPN2 PTPN2 IRS4 IRS4 GHSR GHSR PRKCI PRKCI ITGA4 ITGA4 PPARG PPARG PHIP PHIP LOC103087308 LOC103087308 NR4A3 NR4A3 TYK2 TYK2 FER FER JAK1 JAK1 PTPN22 PTPN22 LHCGR LHCGR RHOQ RHOQ GCGR GCGR PIK3R2 PIK3R2 JAK3 JAK3 SLC27A1 SLC27A1 RELA RELA GRM5 GRM5 CA2 CA2 NOD2 NOD2 ZNF106 ZNF106 PSEN1 PSEN1 RAB8A RAB8A GSK3A GSK3A LOC103074337 LOC103074337 SHC1 SHC1 LOC103085888 LOC103085888 TREM2 TREM2 RAB12 RAB12 RAB31 RAB31 AKT2 AKT2 INSR INSR ENPP1 ENPP1 LPIN2 LPIN2 CSRP3 CSRP3 GH1 GH1 AGER AGER GLP1R GLP1R INSIG1 INSIG1 MAS1 MAS1 GLP2R GLP2R RPE65 RPE65 LOC103083048 LOC103083048 SLC2A4 SLC2A4 INSRR INSRR APP APP LOC103089121 LOC103089121 KL KL NGFR NGFR NOD1 NOD1 NFKB1 NFKB1 WDTC1 WDTC1 PTPRA PTPRA AGTRAP AGTRAP ADIPOQ ADIPOQ AGTR1 AGTR1 PRKCD PRKCD LOC103087942 LOC103087942 SRC SRC STAT5B STAT5B SMARCC1 SMARCC1 GRB10 GRB10 PTPN1 PTPN1 EDN1 EDN1 ADRB2 ADRB2 TBC1D4 TBC1D4 SOGA1 SOGA1 RIPK2 RIPK2 STAT5A STAT5A TRIB3 TRIB3 STAT3 STAT3 GRB14 GRB14 PCK2 PCK2 GSK3B GSK3B STXBP4 STXBP4 CAMK2A CAMK2A LOC103090198 LOC103090198 CAV2 CAV2 PPP1R12A PPP1R12A AHCYL1 AHCYL1 PDK4 PDK4 OTOP1 OTOP1 RAB15 RAB15 RPS6KB1 RPS6KB1 C2CD5 C2CD5 IRS2 IRS2 PCK1 PCK1 SMPD3 SMPD3 FYN FYN GNRHR GNRHR PIK3R3 PIK3R3 UMODL1 UMODL1 JAK2 JAK2 SLC39A14 SLC39A14 APC APC CAV1 CAV1 APPL1 APPL1 LOC103068417 LOC103068417 NCOA5 NCOA5 TUSC5 TUSC5 ACTN2 ACTN2 RIPK1 RIPK1 LOC103090748 LOC103090748 NR4A1 NR4A1 SYAP1 SYAP1 SLC30A10 SLC30A10 LOC103074205 LOC103074205 SLC25A33 SLC25A33 PDPK1 PDPK1 INPP5K INPP5K GPLD1 GPLD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
MGARPProtein MGARP. (240 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1-like. (338 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform X1. (975 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LGMNLegumain. (434 aa)
EPRSLOW QUALITY PROTEIN: bifunctional glutamate/proline--tRNA ligase. (1519 aa)
NDEL1Nuclear distribution protein nudE-like 1 isoform X1. (345 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (987 aa)
RAB13Ras-related protein Rab-13. (203 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
LOC103075410Rho-related GTP-binding protein RhoQ-like. (205 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
SOCS2Suppressor of cytokine signaling 2 isoform X1. (198 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1. (959 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (437 aa)
TIMELESSProtein timeless homolog. (1202 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 isoform X1. (825 aa)
EPHA4Ephrin type-A receptor 4-like isoform X1. (986 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (452 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
CACNB1LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1. (678 aa)
PCSK9LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9. (659 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (479 aa)
FOXO1Forkhead box protein O1. (655 aa)
POU4F2POU domain protein. (408 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
DNAI1Dynein intermediate chain 1, axonemal. (697 aa)
KAT2BHistone acetyltransferase KAT2B. (735 aa)
RAB10Ras-related protein Rab-10. (200 aa)
GOT1Aspartate aminotransferase. (413 aa)
EDNRAEndothelin-1 receptor isoform X2. (318 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
DENND4CDENN domain-containing protein 4C. (1907 aa)
INHBBInhibin beta B chain. (511 aa)
FOXO4Forkhead box protein O4 isoform X1. (512 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2295 aa)
RARRES2Retinoic acid receptor responder protein 2. (163 aa)
SH2B2SH2B adapter protein 2. (660 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
CAPN10Calpain-10; Belongs to the peptidase C2 family. (645 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
LPIN3Phosphatidate phosphatase LPIN3. (851 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4131 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
LOC103078777Rho-related GTP-binding protein RhoQ-like isoform X1. (249 aa)
AGTR2Type-2 angiotensin II receptor-like; Belongs to the G-protein coupled receptor 1 family. (363 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PHIPPH-interacting protein. (1822 aa)
LOC103087308Protein FAM127-like. (113 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3 isoform X1. (636 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (808 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
RHOQRho-related GTP-binding protein RhoQ. (197 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
SLC27A1Long-chain fatty acid transport protein 1. (646 aa)
RELATranscription factor p65 isoform X1. (560 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1204 aa)
CA2Carbonic anhydrase 2 isoform X1; Belongs to the alpha-carbonic anhydrase family. (260 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
ZNF106LOW QUALITY PROTEIN: zinc finger protein 106. (1883 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
LOC103074337LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor-like. (289 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
LOC103085888Corticotropin-releasing factor receptor 1-like. (129 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
RAB12Ras-related protein Rab-12. (244 aa)
RAB31Ras-related protein Rab-31. (205 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
LPIN2Phosphatidate phosphatase LPIN2 isoform X1. (917 aa)
CSRP3Cysteine and glycine-rich protein 3. (194 aa)
GH1Somatotropin. (216 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (421 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (276 aa)
MAS1Proto-oncogene Mas; Belongs to the G-protein coupled receptor 1 family. (325 aa)
GLP2RGlucagon-like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (553 aa)
RPE65Retinoid isomerohydrolase. (533 aa)
LOC103083048Protein phosphatase 1 regulatory subunit 12A-like. (94 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
LOC103089121Cytochrome P450 11B1, mitochondrial-like isoform X1; Belongs to the cytochrome P450 family. (503 aa)
KLKlotho. (1012 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
WDTC1WD and tetratricopeptide repeats protein 1 isoform X1. (679 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
AGTRAPType-1 angiotensin II receptor-associated protein. (148 aa)
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
LOC103087942Signal transducer and activator of transcription 5A-like. (237 aa)
SRCTyrosine-protein kinase. (548 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
SMARCC1SWI/SNF complex subunit SMARCC1. (996 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
EDN1Endothelin-1. (202 aa)
ADRB2Beta-2 adrenergic receptor. (419 aa)
TBC1D4LOW QUALITY PROTEIN: TBC1 domain family member 4. (1296 aa)
SOGA1Protein SOGA1 isoform X1. (1459 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (349 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
GRB14Growth factor receptor-bound protein 14 isoform X1. (540 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
STXBP4Syntaxin-binding protein 4. (558 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
LOC103090198Protein LDOC1-like. (146 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (943 aa)
AHCYL1Adenosylhomocysteinase. (530 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
OTOP1Otopetrin-1-like. (609 aa)
RAB15Ras-related protein Rab-15. (212 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
C2CD5C2 domain-containing protein 5 isoform X4. (1054 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
SMPD3Sphingomyelin phosphodiesterase 3 isoform X1. (654 aa)
FYNTyrosine-protein kinase. (537 aa)
GNRHRGonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
UMODL1Uromodulin-like 1. (1317 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SLC39A14Zinc transporter ZIP14. (523 aa)
APCAdenomatous polyposis coli protein isoform X1. (2847 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
LOC103068417c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (334 aa)
NCOA5Nuclear receptor coactivator 5. (579 aa)
TUSC5Tumor suppressor candidate 5 homolog. (177 aa)
ACTN2Alpha-actinin-2 isoform X1. (907 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (523 aa)
LOC103090748Zinc finger protein 36, C3H1 type-like 1-like. (226 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1 isoform X1. (598 aa)
SYAP1Synapse-associated protein 1 isoform X1. (358 aa)
SLC30A10Zinc transporter 10. (485 aa)
LOC103074205Cytoplasmic polyadenylation element-binding protein 2-like. (738 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (450 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (839 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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