STRINGSTRING
LOC103073470 LOC103073470 RFFL RFFL GSK3B GSK3B RNF34 RNF34 FGB FGB BRCA1 BRCA1 LOC103068503 LOC103068503 TMBIM1 TMBIM1 TNFAIP3 TNFAIP3 FAIM2 FAIM2 PARK7 PARK7 HMOX1 HMOX1 DDX3X DDX3X PEA15 PEA15 LOC103082426 LOC103082426 RAF1 RAF1 FAIM FAIM ITPRIPL2 ITPRIPL2 SFRP2 SFRP2 HGF HGF CFLAR CFLAR ITPRIP ITPRIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103073470Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X1. (392 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (374 aa)
FGBFibrinogen beta chain isoform X1. (488 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa)
LOC103068503LOW QUALITY PROTEIN: fibrinogen gamma-B chain-like. (445 aa)
TMBIM1Protein lifeguard 3; Belongs to the BI1 family. (308 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (315 aa)
PARK7Protein DJ-1. (189 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
LOC103082426Protein lifeguard 2-like; Belongs to the BI1 family. (303 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
FAIMFas apoptotic inhibitory molecule 1. (247 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (509 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein. (556 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (20%) [HD]