STRINGSTRING
ITPRIP ITPRIP TERT TERT ITGAV ITGAV PHIP PHIP LOC103082426 LOC103082426 RELA RELA PELI3 PELI3 FGF10 FGF10 TGFBR1 TGFBR1 SCG2 SCG2 CTNNA1 CTNNA1 EYA1 EYA1 ITGA6 ITGA6 PEA15 PEA15 NOL3 NOL3 SIAH2 SIAH2 HTT HTT EYA3 EYA3 SH3RF1 SH3RF1 DDX3X DDX3X LMNA LMNA HMOX1 HMOX1 IL7 IL7 UNC5B UNC5B GDNF GDNF PARK7 PARK7 FAIM2 FAIM2 TNFAIP3 TNFAIP3 PAK7 PAK7 PSME3 PSME3 RNF34 RNF34 GSK3B GSK3B LOC103087231 LOC103087231 YAP1 YAP1 SGK3 SGK3 RFFL RFFL LGALS3 LGALS3 ZMYND11 ZMYND11 SRC SRC AR AR IL1B IL1B EYA2 EYA2 BMP4 BMP4 HGF HGF CFLAR CFLAR STRADB STRADB GCLM GCLM ZC3HC1 ZC3HC1 GFRAL GFRAL TMBIM1 TMBIM1 RAF1 RAF1 CSF2 CSF2 RB1CC1 RB1CC1 BCL2 BCL2 COL2A1 COL2A1 FAIM FAIM ITPRIPL2 ITPRIPL2 SFRP2 SFRP2 CTTN CTTN LOC103073470 LOC103073470 LOC103077248 LOC103077248 BIRC6 BIRC6 EYA4 EYA4 LOC103068503 LOC103068503 BRCA1 BRCA1 FGB FGB RPS6KB1 RPS6KB1 GATA1 GATA1 MAPK7 MAPK7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPRIPInositol 1,4,5-trisphosphate receptor-interacting protein. (556 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1127 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1311 aa)
PHIPPH-interacting protein. (1822 aa)
LOC103082426Protein lifeguard 2-like; Belongs to the BI1 family. (303 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
SCG2Secretogranin-2. (616 aa)
CTNNA1Catenin alpha-1 isoform X1. (906 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (594 aa)
ITGA6Integrin alpha-6; Belongs to the integrin alpha chain family. (1091 aa)
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
NOL3Nucleolar protein 3. (202 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (296 aa)
HTTHuntingtin. (3137 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (843 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
LMNAprelamin-A/C isoform X1; Belongs to the intermediate filament family. (664 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
IL7Interleukin-7 isoform X2. (178 aa)
UNC5BNetrin receptor UNC5B isoform X1. (935 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
PARK7Protein DJ-1. (189 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (315 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
PAK7Non-specific serine/threonine protein kinase. (719 aa)
PSME3Proteasome activator complex subunit 3 isoform X1. (272 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (374 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC103087231Yorkie homolog isoform X1. (489 aa)
YAP1Yorkie homolog. (430 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X1. (392 aa)
LGALS3Galectin. (256 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (445 aa)
SRCTyrosine-protein kinase. (548 aa)
ARAndrogen receptor. (888 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (537 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (509 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
GCLMGlutamate--cysteine ligase regulatory subunit. (258 aa)
ZC3HC1Nuclear-interacting partner of ALK isoform X1. (503 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (544 aa)
TMBIM1Protein lifeguard 3; Belongs to the BI1 family. (308 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
RB1CC1RB1-inducible coiled-coil protein 1. (1589 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
COL2A1Collagen alpha-1(II) chain isoform X1. (1487 aa)
FAIMFas apoptotic inhibitory molecule 1. (247 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
CTTNSrc substrate cortactin isoform X1. (538 aa)
LOC103073470Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa)
LOC103077248Zinc finger MYND domain-containing protein 11-like. (146 aa)
BIRC6LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6. (4861 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (570 aa)
LOC103068503LOW QUALITY PROTEIN: fibrinogen gamma-B chain-like. (445 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa)
FGBFibrinogen beta chain isoform X1. (488 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GATA1Erythroid transcription factor. (413 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (774 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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