STRINGSTRING
STIM1 STIM1 PDE4B PDE4B PRRT1 PRRT1 GNB5 GNB5 CTSS CTSS EPHB2 EPHB2 CASQ1 CASQ1 NETO1 NETO1 LOC103076006 LOC103076006 RASGRF1 RASGRF1 CALM3 CALM3 CACNG8 CACNG8 JSRP1 JSRP1 KCNAB1 KCNAB1 LOC103089871 LOC103089871 SEPN1 SEPN1 HTT HTT LRRC26 LRRC26 CACNG7 CACNG7 OPRM1 OPRM1 NOS1AP NOS1AP TREM2 TREM2 LRRC55 LRRC55 VAMP2 VAMP2 FAM173B FAM173B CACNG5 CACNG5 LOC103083779 LOC103083779 LRRC52 LRRC52 PIRT PIRT DRD3 DRD3 RRAD RRAD KCNS2 KCNS2 FKBP1B FKBP1B CASQ2 CASQ2 DLG2 DLG2 GALR2 GALR2 SHANK3 SHANK3 MAPK8IP2 MAPK8IP2 CNIH3 CNIH3 RNF207 RNF207 SHISA8 SHISA8 SHISA6 SHISA6 GSG1L GSG1L GEM GEM PLN PLN GSG1 GSG1 ACTN2 ACTN2 DRD2 DRD2 PLCG2 PLCG2 RASGRF2 RASGRF2 TMEM110 TMEM110 CAV1 CAV1 NETO2 NETO2 LOC103074306 LOC103074306 AKAP6 AKAP6 PKD2 PKD2 CRBN CRBN CABP4 CABP4 MMP9 MMP9 CACNB3 CACNB3 GRP GRP STIM2 STIM2 AMIGO1 AMIGO1 CABP2 CABP2 CABP1 CABP1 CACNG3 CACNG3 REM2 REM2 REM1 REM1 ABCC9 ABCC9 CACNG2 CACNG2 DAPK1 DAPK1 KCNE2 KCNE2 SRI SRI KCNG1 KCNG1 AMIGO3 AMIGO3 CACNB2 CACNB2 TRDN TRDN KCNE1 KCNE1 CRH CRH ADRB2 ADRB2 EDN1 EDN1 LOC103087775 LOC103087775 KCNE3 KCNE3 LOC103070646 LOC103070646 ITGB1 ITGB1 CALM1 CALM1 EDNRA EDNRA HOMER1 HOMER1 CRHBP CRHBP EFCAB4B EFCAB4B KLHL24 KLHL24 HPCA HPCA JPH3 JPH3 STAC3 STAC3 LOC103072080 LOC103072080 UBQLN1 UBQLN1 EPO EPO RELN RELN FGF12 FGF12 SLMAP SLMAP SHISA7 SHISA7 KCNRG KCNRG R3HDM2 R3HDM2 KCNQ1 KCNQ1 DLG1 DLG1 LOC103074541 LOC103074541 RAB44 RAB44 STAC2 STAC2 CACNB1 CACNB1 DRD4 DRD4 CLIC2 CLIC2 R3HDM1 R3HDM1 ARC ARC KCNE1L KCNE1L CABP5 CABP5 HAP1 HAP1 STAC STAC SHISA9 SHISA9 NLGN1 NLGN1 KCNS1 KCNS1 SHANK1 SHANK1 KCNE4 KCNE4 LRRC38 LRRC38 CNIH2 CNIH2 CACNB4 CACNB4 FGF14 FGF14 HRC HRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STIM1Stromal interaction molecule 1 isoform X1. (785 aa)
PDE4BPhosphodiesterase. (739 aa)
PRRT1Proline-rich transmembrane protein 1. (305 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (395 aa)
CTSSCathepsin S isoform X1; Belongs to the peptidase C1 family. (340 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (964 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
NETO1Neuropilin and tolloid-like protein 1 isoform X1. (532 aa)
LOC103076006Fibroblast growth factor 11-like; Belongs to the heparin-binding growth factors family. (174 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1 isoform X2. (1273 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (448 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (325 aa)
KCNAB1Voltage-gated potassium channel subunit beta-1 isoform X1. (419 aa)
LOC103089871Sulfate/thiosulfate import ATP-binding protein cysA-like. (208 aa)
SEPN1LOW QUALITY PROTEIN: selenoprotein N. (557 aa)
HTTHuntingtin. (3137 aa)
LRRC26Leucine-rich repeat-containing protein 26. (417 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (479 aa)
NOS1APUncharacterized protein C1orf226 homolog isoform X1. (767 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
LRRC55Leucine-rich repeat-containing protein 55. (318 aa)
VAMP2Vesicle-associated membrane protein 2. (116 aa)
FAM173BLOW QUALITY PROTEIN: protein FAM173B. (287 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
LOC103083779Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (261 aa)
LRRC52Leucine-rich repeat-containing protein 52. (315 aa)
PIRTPhosphoinositide-interacting protein. (222 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
KCNS2Potassium voltage-gated channel subfamily S member 2; Belongs to the potassium channel family. (477 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (410 aa)
DLG2Disks large homolog 2-like isoform X1. (905 aa)
GALR2LOW QUALITY PROTEIN: galanin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (656 aa)
SHANK3SH3 and multiple ankyrin repeat domains protein 3. (1586 aa)
MAPK8IP2c-Jun-amino-terminal kinase-interacting protein 2. (808 aa)
CNIH3Protein cornichon homolog 3. (160 aa)
RNF207RING finger protein 207. (591 aa)
SHISA8Uncharacterized protein. (347 aa)
SHISA6Protein shisa-6 homolog isoform X1. (553 aa)
GSG1LGerm cell-specific gene 1-like protein. (335 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
GSG1LOW QUALITY PROTEIN: germ cell-specific gene 1 protein. (364 aa)
ACTN2Alpha-actinin-2 isoform X1. (907 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
RASGRF2Ras-specific guanine nucleotide-releasing factor 2. (1239 aa)
TMEM110Transmembrane protein 110. (294 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NETO2Neuropilin and tolloid-like protein 2. (518 aa)
LOC103074306R3H domain-containing protein 1-like. (460 aa)
AKAP6A-kinase anchor protein 6. (2320 aa)
PKD2LOW QUALITY PROTEIN: polycystin-2. (963 aa)
CRBNProtein cereblon isoform X1. (444 aa)
CABP4Calcium-binding protein 4. (272 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
GRPGastrin-releasing peptide isoform X1. (139 aa)
STIM2Stromal interaction molecule 2 isoform X1. (838 aa)
AMIGO1Amphoterin-induced protein 1 isoform X1. (493 aa)
CABP2Calcium-binding protein 2 isoform X1. (168 aa)
CABP1Calcium-binding protein 1 isoform X1. (368 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
ABCC9ATP-binding cassette sub-family C member 9 isoform X1. (1549 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
DAPK1Death-associated protein kinase 1 isoform X1. (1430 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2. (123 aa)
SRISorcin. (198 aa)
KCNG1Potassium voltage-gated channel subfamily G member 1; Belongs to the potassium channel family. (514 aa)
AMIGO3Amphoterin-induced protein 3. (510 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (651 aa)
TRDNTriadin. (702 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1. (129 aa)
CRHCorticoliberin. (193 aa)
ADRB2Beta-2 adrenergic receptor. (419 aa)
EDN1Endothelin-1. (202 aa)
LOC103087775LOW QUALITY PROTEIN: R3H domain-containing protein 1-like. (916 aa)
KCNE3Potassium voltage-gated channel subfamily E member 3. (99 aa)
LOC103070646Uncharacterized protein. (454 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
EDNRAEndothelin-1 receptor isoform X2. (318 aa)
HOMER1Homer protein homolog 1. (354 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
EFCAB4BEF-hand calcium-binding domain-containing protein 4B isoform X1. (721 aa)
KLHL24Kelch-like protein 24. (600 aa)
HPCANeuron-specific calcium-binding protein hippocalcin. (193 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (738 aa)
STAC3SH3 and cysteine-rich domain-containing protein 3 isoform X1. (362 aa)
LOC103072080Small ubiquitin-related modifier. (106 aa)
UBQLN1Ubiquilin-1 isoform X1. (590 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
RELNReelin isoform X1. (3460 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
SLMAPSarcolemmal membrane-associated protein isoform X1. (696 aa)
SHISA7Protein shisa-7. (543 aa)
KCNRGPotassium channel regulatory protein. (273 aa)
R3HDM2R3H domain-containing protein 2 isoform X1. (988 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (580 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
RAB44Ras-related protein Rab-44. (931 aa)
STAC2SH3 and cysteine-rich domain-containing protein 2. (416 aa)
CACNB1LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1. (678 aa)
DRD4LOW QUALITY PROTEIN: D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
CLIC2Chloride intracellular channel protein 2. (247 aa)
R3HDM1R3H domain-containing protein 1-like. (636 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
KCNE1LPotassium voltage-gated channel subfamily E member 1-like protein. (145 aa)
CABP5Calcium-binding protein 5 isoform X1. (173 aa)
HAP1LOW QUALITY PROTEIN: huntingtin-associated protein 1. (550 aa)
STACSH3 and cysteine-rich domain-containing protein isoform X1. (402 aa)
SHISA9Protein shisa-9. (425 aa)
NLGN1Neuroligin-1 isoform X1. (863 aa)
KCNS1Potassium voltage-gated channel subfamily S member 1; Belongs to the potassium channel family. (545 aa)
SHANK1LOW QUALITY PROTEIN: SH3 and multiple ankyrin repeat domains protein 1. (2143 aa)
KCNE4Potassium voltage-gated channel subfamily E member 4. (170 aa)
LRRC38Leucine-rich repeat-containing protein 38. (440 aa)
CNIH2Protein cornichon homolog 2. (160 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
HRCSarcoplasmic reticulum histidine-rich calcium-binding protein. (628 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.