(54 nodes) ATPase, AAA-type, core network (Lipotes vexillifer)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	YME1L1	ATP-dependent zinc metalloprotease YME1L1 isoform X1. (715 aa)
	ORC1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa)
	LONP1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (958 aa)
	IQCA1	IQ and AAA domain-containing protein 1. (361 aa)
	LOC103069148	Fidgetin-like; Belongs to the AAA ATPase family. (748 aa)
	SPATA5L1	Spermatogenesis-associated protein 5-like protein 1 isoform X1. (767 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (466 aa)
	VPS4B	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (443 aa)
	ATAD5	LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5. (1898 aa)
	WRNIP1	ATPase WRNIP1 isoform X1. (637 aa)
	CLPX	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial. (633 aa)
	RFC1	Replication factor C subunit 1. (1245 aa)
	CHTF18	Chromosome transmission fidelity protein 18 homolog. (978 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
	PSMC2	LOW QUALITY PROTEIN: 26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (477 aa)
	SPG7	LOW QUALITY PROTEIN: paraplegin. (793 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
	LOC103072683	ATP-dependent zinc metalloprotease FTSH 5, chloroplastic-like; Belongs to the AAA ATPase family. (634 aa)
	PEX6	Peroxisome assembly factor 2 isoform X1. (980 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
	AFG3L2	LOW QUALITY PROTEIN: AFG3-like protein 2. (814 aa)
	CLPB	Caseinolytic peptidase B protein homolog isoform X1. (707 aa)
	LOC103074975	Putative fidgetin-like protein 2-like. (656 aa)
	NVL	Nuclear valosin-containing protein-like. (856 aa)
	LOC103081436	Mitochondrial chaperone BCS1-like; Belongs to the AAA ATPase family. (419 aa)
	PSMC6	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
	FIGNL1	Fidgetin-like protein 1; Belongs to the AAA ATPase family. (677 aa)
	PEX1	Peroxisome biogenesis factor 1. (1294 aa)
	PSMC4	26S protease regulatory subunit 6B isoform X1; Belongs to the AAA ATPase family. (418 aa)
	ATAD2	ATPase family AAA domain-containing protein 2. (1385 aa)
	LOC103069935	Chaperone protein ClpB2, chloroplastic-like; Belongs to the ClpA/ClpB family. (701 aa)
	LOC103089666	ATPase family AAA domain-containing protein 3-like. (587 aa)
	LOC103088327	Heat shock protein 78, mitochondrial-like; Belongs to the ClpA/ClpB family. (756 aa)
	VPS4A	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (437 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	RFC5	Replication factor C subunit 5. (342 aa)
	PSMC5	26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
	PSMC3	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (423 aa)
	ATAD2B	ATPase family AAA domain-containing protein 2B isoform X1. (1458 aa)
	LOC103085690	Putative fidgetin-like protein 2-like. (495 aa)
	NAV3	Neuron navigator 3-like isoform X1. (2385 aa)
	TRIP13	Pachytene checkpoint protein 2 homolog. (292 aa)
	PSMC1	26S protease regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
	NSF	LOW QUALITY PROTEIN: N-ethylmaleimide-sensitive factor; Belongs to the AAA ATPase family. (644 aa)
	LOC103070273	Chaperone protein ClpB2, chloroplastic-like; Belongs to the ClpA/ClpB family. (854 aa)
	ATAD1	ATPase family AAA domain-containing protein 1; Belongs to the AAA ATPase family. (404 aa)
	KATNAL1	Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa)
	SPATA5	Spermatogenesis-associated protein 5. (887 aa)
	RFC2	Replication factor C subunit 2 isoform X1. (352 aa)
	LOC103085856	ATP-dependent protease ATPase subunit HslU1-like. (447 aa)
	LOC103091337	ATPase WRNIP1 homolog C26H5.02c-like. (412 aa)
	LOC103081553	AFG3-like protein 1-like. (181 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	CLPX	A0A340XW32	A0A340WL38	LOW QUALITY PROTEIN: AFG3-like protein 2.	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial.	0.605
AFG3L2	LOC103085856	A0A340XW32	A0A340Y814	LOW QUALITY PROTEIN: AFG3-like protein 2.	ATP-dependent protease ATPase subunit HslU1-like.	0.605
AFG3L2	LONP1	A0A340XW32	A0A340XMV4	LOW QUALITY PROTEIN: AFG3-like protein 2.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...]	0.647
AFG3L2	LONP2	A0A340XW32	A0A340WUZ4	LOW QUALITY PROTEIN: AFG3-like protein 2.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1.	0.468
AFG3L2	SPG7	A0A340XW32	A0A340Y5I2	LOW QUALITY PROTEIN: AFG3-like protein 2.	LOW QUALITY PROTEIN: paraplegin.	0.637
ATAD2	CDC6	A0A340XA97	A0A340Y1C1	ATPase family AAA domain-containing protein 2.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.617
ATAD2	NVL	A0A340XA97	A0A340WYU1	ATPase family AAA domain-containing protein 2.	Nuclear valosin-containing protein-like.	0.423
ATAD2	PSMC3	A0A340XA97	A0A340X2L0	ATPase family AAA domain-containing protein 2.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.539
ATAD2	PSMC4	A0A340XA97	A0A340XBB0	ATPase family AAA domain-containing protein 2.	26S protease regulatory subunit 6B isoform X1; Belongs to the AAA ATPase family.	0.539
ATAD2	PSMC6	A0A340XA97	A0A340WG60	ATPase family AAA domain-containing protein 2.	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.539
ATAD2	RFC2	A0A340XA97	A0A340YBM4	ATPase family AAA domain-containing protein 2.	Replication factor C subunit 2 isoform X1.	0.456
ATAD2B	CDC6	A0A340X1U6	A0A340Y1C1	ATPase family AAA domain-containing protein 2B isoform X1.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.425
ATAD2B	PSMC3	A0A340X1U6	A0A340X2L0	ATPase family AAA domain-containing protein 2B isoform X1.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.539
ATAD2B	PSMC4	A0A340X1U6	A0A340XBB0	ATPase family AAA domain-containing protein 2B isoform X1.	26S protease regulatory subunit 6B isoform X1; Belongs to the AAA ATPase family.	0.539
ATAD2B	PSMC6	A0A340X1U6	A0A340WG60	ATPase family AAA domain-containing protein 2B isoform X1.	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.539
ATAD5	CDC6	A0A340WZG5	A0A340Y1C1	LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.728
ATAD5	CHTF18	A0A340WZG5	A0A340WX83	LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5.	Chromosome transmission fidelity protein 18 homolog.	0.791
ATAD5	LOC103069148	A0A340WZG5	A0A340WT46	LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5.	Fidgetin-like; Belongs to the AAA ATPase family.	0.459
ATAD5	LOC103074975	A0A340WZG5	A0A340WZA8	LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5.	Putative fidgetin-like protein 2-like.	0.547
ATAD5	LOC103085690	A0A340WZG5	A0A340WZY3	LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5.	Putative fidgetin-like protein 2-like.	0.547