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nadh5 nadh5 nadh4 nadh4 nadh3 nadh3 nadh2 nadh2 nadh1 nadh1 PARP2 PARP2 LOC103070130 LOC103070130 ADH5 ADH5 ART5 ART5 NDUFS7 NDUFS7 LOC103085270 LOC103085270 NADK2 NADK2 ALDH4A1 ALDH4A1 GALE GALE PHGDH PHGDH LOC103086183 LOC103086183 APOA1BP APOA1BP DLD DLD ART3 ART3 NMNAT3 NMNAT3 LOC103083090 LOC103083090 LOC103091064 LOC103091064 GSR GSR IMPDH2 IMPDH2 SIRT5 SIRT5 UGDH UGDH BLVRA BLVRA PARP14 PARP14 LDHB LDHB AHCY AHCY PARP16 PARP16 SIRT4 SIRT4 LOC103073002 LOC103073002 AHCYL1 AHCYL1 LOC103078914 LOC103078914 LOC103087442 LOC103087442 LOC103076353 LOC103076353 LOC103073206 LOC103073206 LOC103070738 LOC103070738 LOC103079025 LOC103079025 LOC103073674 LOC103073674 NDUFS3 NDUFS3 CARKD CARKD ART4 ART4 ALDH5A1 ALDH5A1 HADH HADH LOC103069642 LOC103069642 LOC103073665 LOC103073665 PARP3 PARP3 GPD1 GPD1 NMNAT1 NMNAT1 NDUFV1 NDUFV1 LDHA LDHA GPD1L GPD1L LOC103085452 LOC103085452 HIBADH HIBADH LOC103073812 LOC103073812 PARP10 PARP10 SIRT2 SIRT2 SIRT3 SIRT3 NADSYN1 NADSYN1 LOC103086218 LOC103086218 TXNRD3 TXNRD3 LOC103083711 LOC103083711 ZC3HAV1 ZC3HAV1 NDUFS2 NDUFS2 AHCYL2 AHCYL2 PARP6 PARP6 MDH2 MDH2 IMPDH1 IMPDH1 LOC103078256 LOC103078256 PARP11 PARP11 GAPDH GAPDH PARP8 PARP8 LOC103070897 LOC103070897 GAPDHS GAPDHS LOC103081760 LOC103081760 TNKS2 TNKS2 ND4L ND4L nadh6 nadh6 LOC103078494 LOC103078494 LOC103078790 LOC103078790 LOC103090169 LOC103090169 LOC103073537 LOC103073537 MDH1 MDH1 ART1 ART1 PARP1 PARP1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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nadh5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (606 aa)
nadh4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (459 aa)
nadh3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (115 aa)
nadh2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (347 aa)
nadh1NADH-ubiquinone oxidoreductase chain 1; Belongs to the complex I subunit 1 family. (318 aa)
PARP2Poly [ADP-ribose] polymerase. (591 aa)
LOC103070130Glycerol-3-phosphate dehydrogenase [NAD(+)]. (328 aa)
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
ART5NAD(P)(+)--arginine ADP-ribosyltransferase. (315 aa)
NDUFS7NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Belongs to the complex I 20 kDa subunit family. (231 aa)
LOC103085270NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
NADK2NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (464 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (564 aa)
GALEUDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (348 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
LOC103086183Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa)
APOA1BPNAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
ART3NAD(P)(+)--arginine ADP-ribosyltransferase. (392 aa)
NMNAT3Nicotinamide-nucleotide adenylyltransferase. (239 aa)
LOC103083090NADH-ubiquinone oxidoreductase chain 6-like; Belongs to the complex I subunit 6 family. (166 aa)
LOC103091064Thioredoxin reductase 1, cytoplasmic-like isoform X1. (497 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (503 aa)
BLVRABiliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. (296 aa)
PARP14Poly [ADP-ribose] polymerase. (1797 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
AHCYAdenosylhomocysteinase. (432 aa)
PARP16Poly [ADP-ribose] polymerase. (322 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
LOC103073002Dihydrolipoyl dehydrogenase 1, mitochondrial-like. (464 aa)
AHCYL1Adenosylhomocysteinase. (530 aa)
LOC103078914NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (399 aa)
LOC103087442S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (371 aa)
LOC103076353UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (343 aa)
LOC103073206Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (353 aa)
LOC103070738Glycerol-3-phosphate dehydrogenase [NAD(+)]. (341 aa)
LOC103079025Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
LOC103073674NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (326 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (266 aa)
CARKDATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (530 aa)
ART4NAD(P)(+)--arginine ADP-ribosyltransferase. (322 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (526 aa)
HADHLOW QUALITY PROTEIN: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (374 aa)
LOC103069642NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (309 aa)
LOC103073665Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (534 aa)
PARP3Poly [ADP-ribose] polymerase. (536 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (281 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
LOC1030854523-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (295 aa)
HIBADH3-hydroxyisobutyrate dehydrogenase, mitochondrial. (336 aa)
LOC103073812NAD(P)H-quinone oxidoreductase subunit H, chloroplastic-like; Belongs to the complex I 49 kDa subunit family. (246 aa)
PARP10Poly [ADP-ribose] polymerase. (936 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (334 aa)
NADSYN1Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (706 aa)
LOC1030862183-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa)
TXNRD3Thioredoxin reductase 3. (620 aa)
LOC103083711UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (337 aa)
ZC3HAV1Poly [ADP-ribose] polymerase. (898 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Belongs to the complex I 49 kDa subunit family. (463 aa)
AHCYL2Adenosylhomocysteinase. (611 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
MDH2Malate dehydrogenase. (338 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa)
LOC103078256NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (313 aa)
PARP11Poly [ADP-ribose] polymerase. (338 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
PARP8Poly [ADP-ribose] polymerase. (868 aa)
LOC103070897Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa)
GAPDHSLOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase, testis-specific; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (387 aa)
LOC103081760Dihydrolipoyl dehydrogenase. (485 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
ND4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (98 aa)
nadh6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
LOC103078494Adenosylhomocysteinase. (447 aa)
LOC103078790Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
LOC103090169Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
LOC103073537NADH-ubiquinone oxidoreductase 20 kDa subunit-like; Belongs to the complex I 20 kDa subunit family. (225 aa)
MDH1Malate dehydrogenase. (334 aa)
ART1NAD(P)(+)--arginine ADP-ribosyltransferase. (326 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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