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| | LOC103074978 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC103079983 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | POLA1 | DNA polymerase. (1462 aa) |
| | POLD2 | DNA polymerase delta subunit 2 isoform X1. (469 aa) |
| | ATRX | Transcriptional regulator ATRX. (2485 aa) |
| | SHQ1 | LOW QUALITY PROTEIN: protein SHQ1 homolog. (578 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa) |
| | RFC1 | Replication factor C subunit 1. (1245 aa) |
| | TINF2 | TERF1-interacting nuclear factor 2. (453 aa) |
| | LOC103087596 | H/ACA ribonucleoprotein complex subunit 3-like. (83 aa) |
| | POLD3 | DNA polymerase delta subunit 3. (469 aa) |
| | LOC103076424 | Histone H3.3-like. (136 aa) |
| | POT1 | Protection of telomeres protein 1. (785 aa) |
| | LOC103071163 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | POLD4 | DNA polymerase delta subunit 4. (107 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | LOC103070340 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103071706 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (539 aa) |
| | LOC103071989 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103073911 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PPP6R3 | Serine/threonine-protein phosphatase 6 regulatory subunit 3. (632 aa) |
| | LOC103073365 | Chromosome transmission fidelity protein 8 homolog. (121 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RBPMS2 | RNA-binding protein with multiple splicing 2. (212 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | LOC103081391 | Histone H3.3-like. (172 aa) |
| | CHTF18 | Chromosome transmission fidelity protein 18 homolog. (978 aa) |
| | DSCC1 | Sister chromatid cohesion protein DCC1. (392 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa) |
| | CDK3 | Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | LOC103076444 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (623 aa) |
| | LOC103080676 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | LOC103074048 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa) |
| | PPP6R2 | Serine/threonine-protein phosphatase 6 regulatory subunit 2. (933 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform X1. (471 aa) |
| | TEN1 | CST complex subunit TEN1. (123 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | LOC103088283 | Serine/threonine-protein phosphatase 6 regulatory subunit 3-like. (144 aa) |
| | RFC5 | Replication factor C subunit 5. (342 aa) |
| | ACD | Adrenocortical dysplasia protein homolog. (454 aa) |
| | CTC1 | CST complex subunit CTC1. (1210 aa) |
| | WRAP53 | Telomerase Cajal body protein 1 isoform X2. (543 aa) |
| | LOC103090400 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa) |
| | DAXX | Death domain-associated protein 6. (757 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1. (399 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1249 aa) |
| | LIG1 | DNA ligase. (921 aa) |
| | LOC103079884 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC103081255 | Histone H2B; Belongs to the histone H2B family. (142 aa) |
| | NOP10 | H/ACA ribonucleoprotein complex subunit 3. (73 aa) |
| | CCNA2 | cyclin-A2; Belongs to the cyclin family. (432 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (221 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | LOC103080427 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103081704 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103081970 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | ANKRD44 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1. (986 aa) |
| | LOC103089645 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | CCNA1 | cyclin-A1; Belongs to the cyclin family. (421 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1224 aa) |
| | DKC1 | H/ACA ribonucleoprotein complex subunit 4. (420 aa) |
| | LOC103070776 | Histone H3-like centromeric protein CSE4-like. (277 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (531 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2 isoform X1. (572 aa) |
| | CDK2 | Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa) |
| | LOC103068403 | Histone H2B type W-T-like; Belongs to the histone H2B family. (184 aa) |
| | LOC103068676 | Histone H2B type W-T-like; Belongs to the histone H2B family. (177 aa) |
| | RFC2 | Replication factor C subunit 2 isoform X1. (352 aa) |
| | OBFC1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | LOC103076354 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC103079101 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103081667 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC103082925 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103088169 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | TRUB1 | Probable tRNA pseudouridine synthase 1. (348 aa) |
| | PPP6C | Serine/threonine-protein phosphatase. (349 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1127 aa) |
| | LOC103076894 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103080928 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC103086798 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103082191 | H/ACA ribonucleoprotein complex subunit 3-like. (64 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1430 aa) |
| | ANKRD66 | LOW QUALITY PROTEIN: ankyrin repeat domain 66. (198 aa) |
| | ANKRD28 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X2. (1086 aa) |
| | LOC103074679 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC103076624 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103080666 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103088445 | Histone H2A; Belongs to the histone H2A family. (117 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa) |
| | LOC103077443 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC103085965 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
