STRINGSTRING
YWHAB YWHAB AP2A2 AP2A2 LOC103086582 LOC103086582 FNDC3A FNDC3A PIK3CB PIK3CB PPP2R1B PPP2R1B SH3GL2 SH3GL2 FNDC3B FNDC3B PIK3CA PIK3CA NAB1 NAB1 MAPK14 MAPK14 HRAS HRAS IRS1 IRS1 BRAF BRAF AP2M1 AP2M1 JUNB JUNB RPS6KA3 RPS6KA3 LOC103069787 LOC103069787 NAB2 NAB2 NTF3 NTF3 RALB RALB LYL1 LYL1 CREB1 CREB1 MAPKAPK2 MAPKAPK2 CHD4 CHD4 FURIN FURIN RPS6KA5 RPS6KA5 BDNF BDNF EGR3 EGR3 FYN FYN RPS6KA2 RPS6KA2 LOC103073248 LOC103073248 CRKL CRKL CLTC CLTC RAP1A RAP1A DUSP7 DUSP7 IRS2 IRS2 LOC103083372 LOC103083372 MAPK1 MAPK1 PCSK5 PCSK5 DUSP6 DUSP6 ERAS ERAS MAPK7 MAPK7 RAC1 RAC1 MAP2K1 MAP2K1 PPP4R4 PPP4R4 PPP2CB PPP2CB LOC103070590 LOC103070590 AP2B1 AP2B1 MAP2K5 MAP2K5 EGR2 EGR2 NTRK3 NTRK3 SOS1 SOS1 SRC SRC KRAS KRAS ID4 ID4 SHC3 SHC3 RHOA RHOA RAPGEF1 RAPGEF1 ELK1 ELK1 SGK1 SGK1 EGR4 EGR4 ATF1 ATF1 MAPKAPK3 MAPKAPK3 MAPK11 MAPK11 PCSK6 PCSK6 ASCL1 ASCL1 DNAL4 DNAL4 DOCK3 DOCK3 MAPK3 MAPK3 CRK CRK RALGDS RALGDS DUSP3 DUSP3 FNBP4 FNBP4 NTRK2 NTRK2 GRB2 GRB2 NGF NGF PIK3R1 PIK3R1 PTPRO PTPRO RRAD RRAD KIAA1468 KIAA1468 RIT1 RIT1 NTRK1 NTRK1 SHC1 SHC1 LOC103082213 LOC103082213 PPP2R5D PPP2R5D CLTA CLTA TRIB1 TRIB1 NKPD1 NKPD1 RPS6KA1 RPS6KA1 TRIB2 TRIB2 KIDINS220 KIDINS220 ID3 ID3 ID2 ID2 PPP4R1 PPP4R1 FOSB FOSB AP2S1 AP2S1 LOC103087748 LOC103087748 PCSK4 PCSK4 SHC2 SHC2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 CSDE1 CSDE1 EGR1 EGR1 JUND JUND NTF4 NTF4 VRK3 VRK3 LOC103090072 LOC103090072 PPP2CA PPP2CA RPS6KA4 RPS6KA4 FOSL1 FOSL1 NRAS NRAS AP2A1 AP2A1 MAPK15 MAPK15 PLCG1 PLCG1 RALA RALA FRS2 FRS2 ARC ARC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
LOC103086582Achaete-scute homolog 2-like. (191 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (644 aa)
SH3GL2endophilin-A1. (352 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
NAB1NGFI-A-binding protein 1 isoform X1. (487 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
HRASGTPase HRas isoform X1. (189 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
JUNBTranscription factor jun-B. (347 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
LOC103069787BDNF/NT-3 growth factors receptor-like isoform X1. (553 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (266 aa)
RALBRas-related protein Ral-B. (206 aa)
LYL1Protein lyl-1. (279 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
CHD4chromodomain-helicase-DNA-binding protein 4. (1912 aa)
FURINFurin isoform X1; Belongs to the peptidase S8 family. (792 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (248 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
FYNTyrosine-protein kinase. (537 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
LOC103073248Dual specificity mitogen-activated protein kinase kinase 5-like. (160 aa)
CRKLCrk-like protein. (303 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1818 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
LOC103083372AP-2 complex subunit beta-like. (263 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (913 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ERASGTPase ERas. (233 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (774 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (872 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LOC103070590AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (598 aa)
AP2B1AP-1 complex subunit beta-1 isoform X1. (304 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5-like. (282 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (485 aa)
NTRK3Tyrosine-protein kinase receptor. (839 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
SRCTyrosine-protein kinase. (548 aa)
KRASGTPase KRas. (188 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
SHC3SHC-transforming protein 3. (588 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (444 aa)
SGK1Non-specific serine/threonine protein kinase. (527 aa)
EGR4LOW QUALITY PROTEIN: early growth response protein 4. (589 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (194 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (1138 aa)
ASCL1Achaete-scute homolog 1. (227 aa)
DNAL4Dynein light chain. (105 aa)
DOCK3Dedicator of cytokinesis protein 3; Belongs to the DOCK family. (2025 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (842 aa)
DUSP3Dual specificity protein phosphatase 3 isoform X1. (239 aa)
FNBP4Formin-binding protein 4. (1011 aa)
NTRK2Tyrosine-protein kinase receptor. (366 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1217 aa)
RIT1GTP-binding protein Rit1. (218 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
LOC103082213Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like isoform X1. (589 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
TRIB1Tribbles homolog 1. (372 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1. (871 aa)
RPS6KA1Ribosomal protein S6 kinase. (742 aa)
TRIB2Tribbles homolog 2 isoform X1. (343 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa. (1769 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (949 aa)
FOSBProtein fosB isoform X1. (341 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
LOC103087748Cyclic AMP-dependent transcription factor ATF-1-like. (114 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (843 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (843 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
JUNDTranscription factor jun-D. (345 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
VRK3Inactive serine/threonine-protein kinase VRK3. (457 aa)
LOC103090072Cyclic AMP-responsive element-binding protein 1-like. (47 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
FOSL1Fos-related antigen 1. (271 aa)
NRASGTPase NRas. (189 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
MAPK15LOW QUALITY PROTEIN: mitogen-activated protein kinase 15. (716 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RALARas-related protein Ral-A. (206 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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