STRINGSTRING
RPA1 RPA1 ATRIP ATRIP ATR ATR DBF4 DBF4 HUS1 HUS1 RAD9B RAD9B RPA3 RPA3 MCM3 MCM3 ORC6 ORC6 RAD9A RAD9A RFC4 RFC4 MCM6 MCM6 CDK3 CDK3 ORC4 ORC4 CLSPN CLSPN LOC103072393 LOC103072393 RFC5 RFC5 RAD17 RAD17 MCM5 MCM5 ORC1 ORC1 CDC45 CDC45 MCM10 MCM10 CHEK1 CHEK1 MCM4 MCM4 RFC3 RFC3 MCM2 MCM2 CDC6 CDC6 ORC3 ORC3 ORC5 ORC5 RCBTB1 RCBTB1 RCBTB2 RCBTB2 CDC7 CDC7 RAD1 RAD1 MCM8 MCM8 CDK2 CDK2 MCM7 MCM7 ORC2 ORC2 RFC2 RFC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
ATRIPLOW QUALITY PROTEIN: ATR-interacting protein. (794 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2633 aa)
DBF4Protein DBF4 homolog A isoform X1. (680 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (419 aa)
RFC4Replication factor C subunit 4. (364 aa)
MCM6DNA helicase; Belongs to the MCM family. (829 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
CLSPNClaspin isoform X1. (1335 aa)
LOC103072393Origin recognition complex subunit 6-like. (264 aa)
RFC5Replication factor C subunit 5. (342 aa)
RAD17Cell cycle checkpoint protein RAD17. (709 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa)
CDC45Cell division control protein 45 homolog isoform X1. (567 aa)
MCM10Protein MCM10 homolog. (872 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
MCM4DNA helicase; Belongs to the MCM family. (865 aa)
RFC3Replication factor C subunit 3. (356 aa)
MCM2DNA helicase; Belongs to the MCM family. (991 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
ORC3Origin recognition complex subunit 3 isoform X1. (714 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (572 aa)
CDC7Cell division cycle 7-related protein kinase isoform X1. (577 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
MCM8DNA helicase MCM8 isoform X1; Belongs to the MCM family. (832 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ORC2Origin recognition complex subunit 2 isoform X1. (577 aa)
RFC2Replication factor C subunit 2 isoform X1. (352 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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