STRINGSTRING
PPP2CB PPP2CB RPS6KA5 RPS6KA5 CHD4 CHD4 MAPKAPK2 MAPKAPK2 CREB1 CREB1 LYL1 LYL1 RALB RALB NAB2 NAB2 RPS6KA3 RPS6KA3 JUNB JUNB AP2M1 AP2M1 BRAF BRAF IRS1 IRS1 HRAS HRAS MAPK14 MAPK14 NAB1 NAB1 PIK3CA PIK3CA SH3GL2 SH3GL2 PPP2R1B PPP2R1B PIK3CB PIK3CB LOC103086582 LOC103086582 AP2A2 AP2A2 YWHAB YWHAB ARC ARC FRS2 FRS2 RALA RALA MAPK15 MAPK15 AP2A1 AP2A1 NRAS NRAS FOSL1 FOSL1 RPS6KA4 RPS6KA4 PPP2CA PPP2CA LOC103090072 LOC103090072 VRK3 VRK3 JUND JUND EGR1 EGR1 CSDE1 CSDE1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 SHC2 SHC2 LOC103087748 LOC103087748 AP2S1 AP2S1 FOSB FOSB PPP4R1 PPP4R1 ID2 ID2 ID3 ID3 KIDINS220 KIDINS220 TRIB2 TRIB2 RPS6KA1 RPS6KA1 NKPD1 NKPD1 TRIB1 TRIB1 CLTA CLTA PPP2R5D PPP2R5D LOC103082213 LOC103082213 SHC1 SHC1 NTRK1 NTRK1 RIT1 RIT1 KIAA1468 KIAA1468 RRAD RRAD PIK3R1 PIK3R1 NGF NGF GRB2 GRB2 FNBP4 FNBP4 DUSP3 DUSP3 RALGDS RALGDS CRK CRK MAPK3 MAPK3 DNAL4 DNAL4 ASCL1 ASCL1 MAPK11 MAPK11 MAPKAPK3 MAPKAPK3 ATF1 ATF1 EGR4 EGR4 SGK1 SGK1 ELK1 ELK1 RAPGEF1 RAPGEF1 EGR3 EGR3 DUSP7 DUSP7 IRS2 IRS2 CRKL CRKL CLTC CLTC RAP1A RAP1A LOC103083372 LOC103083372 MAPK1 MAPK1 DUSP6 DUSP6 ERAS ERAS MAPK7 MAPK7 MAP2K1 MAP2K1 PPP4R4 PPP4R4 LOC103070590 LOC103070590 AP2B1 AP2B1 MAP2K5 MAP2K5 EGR2 EGR2 SOS1 SOS1 KRAS KRAS ID4 ID4 SHC3 SHC3 RHOA RHOA RPS6KA2 RPS6KA2 LOC103073248 LOC103073248
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
CHD4chromodomain-helicase-DNA-binding protein 4. (1912 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
LYL1Protein lyl-1. (279 aa)
RALBRas-related protein Ral-B. (206 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
JUNBTranscription factor jun-B. (347 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NAB1NGFI-A-binding protein 1 isoform X1. (487 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
SH3GL2endophilin-A1. (352 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (644 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LOC103086582Achaete-scute homolog 2-like. (191 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (938 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
RALARas-related protein Ral-A. (206 aa)
MAPK15LOW QUALITY PROTEIN: mitogen-activated protein kinase 15. (716 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
NRASGTPase NRas. (189 aa)
FOSL1Fos-related antigen 1. (271 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LOC103090072Cyclic AMP-responsive element-binding protein 1-like. (47 aa)
VRK3Inactive serine/threonine-protein kinase VRK3. (457 aa)
JUNDTranscription factor jun-D. (345 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (843 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SHC2SHC-transforming protein 2. (801 aa)
LOC103087748Cyclic AMP-dependent transcription factor ATF-1-like. (114 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
FOSBProtein fosB isoform X1. (341 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (949 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa. (1769 aa)
TRIB2Tribbles homolog 2 isoform X1. (343 aa)
RPS6KA1Ribosomal protein S6 kinase. (742 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1. (871 aa)
TRIB1Tribbles homolog 1. (372 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
LOC103082213Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like isoform X1. (589 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
RIT1GTP-binding protein Rit1. (218 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1217 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FNBP4Formin-binding protein 4. (1011 aa)
DUSP3Dual specificity protein phosphatase 3 isoform X1. (239 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (842 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
DNAL4Dynein light chain. (105 aa)
ASCL1Achaete-scute homolog 1. (227 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (194 aa)
EGR4LOW QUALITY PROTEIN: early growth response protein 4. (589 aa)
SGK1Non-specific serine/threonine protein kinase. (527 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (444 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
CRKLCrk-like protein. (303 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1818 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
LOC103083372AP-2 complex subunit beta-like. (263 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ERASGTPase ERas. (233 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (774 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (872 aa)
LOC103070590AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (598 aa)
AP2B1AP-1 complex subunit beta-1 isoform X1. (304 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5-like. (282 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (485 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
KRASGTPase KRas. (188 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
SHC3SHC-transforming protein 3. (588 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
LOC103073248Dual specificity mitogen-activated protein kinase kinase 5-like. (160 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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