STRINGSTRING
PIP4K2B PIP4K2B FGF16 FGF16 SRC SRC CD276 CD276 PPP2CB PPP2CB PPP4R4 PPP4R4 CD80 CD80 PDGFRB PDGFRB RAC1 RAC1 MET MET MAPK1 MAPK1 INSC INSC IL33 IL33 FAM102B FAM102B KLB KLB KITLG KITLG IER3 IER3 IRS2 IRS2 PPP2R5A PPP2R5A CD86 CD86 LOC103084935 LOC103084935 FYN FYN PIK3R3 PIK3R3 LOC103088795 LOC103088795 FGF17 FGF17 PIK3CD PIK3CD STRN3 STRN3 PIP4K2A PIP4K2A MAPK3 MAPK3 CD19 CD19 TGFA TGFA CD28 CD28 FGF7 FGF7 FNBP4 FNBP4 PDGFRA PDGFRA PIK3AP1 PIK3AP1 RAC2 RAC2 PDGFB PDGFB GRB2 GRB2 PIK3R1 PIK3R1 ICOS ICOS KIAA1468 KIAA1468 GAB2 GAB2 PPP2R5C PPP2R5C LOC103082213 LOC103082213 NRG3 NRG3 PPP2R5D PPP2R5D KIT KIT ESR1 ESR1 IRAK1 IRAK1 IL1RL1 IL1RL1 PPP4R1 PPP4R1 PPP2R5E PPP2R5E PIP5K1A PIP5K1A THEM4 THEM4 PIP5K1C PIP5K1C FGF22 FGF22 INSR INSR STRN4 STRN4 ESR2 ESR2 HBEGF HBEGF FGF10 FGF10 FGF20 FGF20 PIK3R2 PIK3R2 IRAK4 IRAK4 MYD88 MYD88 NRG2 NRG2 VAV1 VAV1 PHLPP2 PHLPP2 AREG AREG EREG EREG PPP2CA PPP2CA EGFR EGFR PPP2R5B PPP2R5B BTC BTC EPGN EPGN FLT3LG FLT3LG WDR64 WDR64 BANK1 BANK1 FGFR4 FGFR4 ERBB2 ERBB2 EGF EGF RHOG RHOG FRS2 FRS2 FGF9 FGF9 PHLPP1 PHLPP1 GAB1 GAB1 LOC103081170 LOC103081170 KL KL FNDC3A FNDC3A PIK3CB PIK3CB PPP2R1B PPP2R1B PIP5K1B PIP5K1B FNDC3B FNDC3B PIK3CA PIK3CA FGF4 FGF4 LOC103088508 LOC103088508 NRG1 NRG1 PDGFA PDGFA FGF18 FGF18 FGFR3 FGFR3 INS INS IRS1 IRS1 FGF5 FGF5 NRG4 NRG4 FAM102A FAM102A LRRC40 LRRC40 FGF3 FGF3 PIP5KL1 PIP5KL1 LOC103083466 LOC103083466 FLT3 FLT3 FGF8 FGF8 FGFR1 FGFR1 LCK LCK PTPN11 PTPN11 FGFR2 FGFR2 FGF2 FGF2 PTEN PTEN ERBB4 ERBB4 PIP4K2C PIP4K2C FGF23 FGF23 FGF6 FGF6 ERBB3 ERBB3 FGF1 FGF1 HGF HGF STRN STRN IL1RAP IL1RAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (370 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SRCTyrosine-protein kinase. (548 aa)
CD276CD276 antigen isoform X1. (535 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (872 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (234 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
INSCProtein inscuteable homolog isoform X1. (579 aa)
IL33LOW QUALITY PROTEIN: interleukin-33. (485 aa)
FAM102BProtein FAM102B-like. (361 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1042 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (156 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (469 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (328 aa)
LOC103084935T-cell receptor-associated transmembrane adapter 1-like. (218 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
STRN3Striatin-3 isoform X1. (796 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (406 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CD19B-lymphocyte antigen CD19. (568 aa)
TGFAProtransforming growth factor alpha. (145 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FNBP4Formin-binding protein 4. (1011 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (801 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ICOSInducible T-cell costimulator. (318 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1217 aa)
GAB2GRB2-associated-binding protein 2. (640 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
LOC103082213Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like isoform X1. (589 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (613 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
IL1RL1Interleukin-1 receptor-like 1. (327 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (949 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (239 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (828 aa)
FGF22LOW QUALITY PROTEIN: fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (229 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
STRN4Striatin-4 isoform X1. (766 aa)
ESR2Estrogen receptor beta. (533 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (757 aa)
VAV1Proto-oncogene vav isoform X1. (844 aa)
PHLPP2PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1. (1353 aa)
AREGAmphiregulin isoform X1. (254 aa)
EREGProepiregulin. (163 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
BTCProbetacellulin. (178 aa)
EPGNEpigen isoform X1. (153 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (296 aa)
WDR64WD repeat-containing protein 64. (1080 aa)
BANK1B-cell scaffold protein with ankyrin repeats. (751 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PHLPP1PH domain leucine-rich repeat-containing protein phosphatase 1. (1693 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
LOC103081170Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (465 aa)
KLKlotho. (1012 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (644 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (540 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LOC103088508TNF receptor-associated factor 6-like. (251 aa)
NRG1Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (641 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (266 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
FAM102AProtein FAM102A. (384 aa)
LRRC40Leucine-rich repeat-containing protein 40. (613 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (396 aa)
LOC103083466Rho-related GTP-binding protein RhoG-like. (191 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
LCKTyrosine-protein kinase. (520 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1. (421 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
STRNStriatin isoform X1. (780 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X2. (687 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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