32 items (Lipotes vexillifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERAS	GTPase ERas. (233 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (584 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform X1. (217 aa)
	GRAP2	GRB2-related adapter protein 2. (317 aa)
	LAT	Linker for activation of T-cells family member 1. (260 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	SPNS3	Protein spinster homolog 3. (518 aa)
	SPNS1	Protein spinster homolog 1 isoform X1. (552 aa)
	VAV2	Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
	VAV3	Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
	SOS1	Son of sevenless homolog 1. (1333 aa)
	LCP2	Lymphocyte cytosolic protein 2. (532 aa)
	SYK	Tyrosine-protein kinase SYK isoform X1. (636 aa)
	KRAS	GTPase KRas. (188 aa)
	LOC103070953	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (843 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	NRAS	GTPase NRas. (189 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	KLRC1	NKG2-A/NKG2-B type II integral membrane protein. (237 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	LCK	Tyrosine-protein kinase. (520 aa)
	KLRD1	Natural killer cells antigen CD94. (228 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein isoform X1. (97 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	KLRC1	A0A340Y6E3	A0A340Y6Y0	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	NKG2-A/NKG2-B type II integral membrane protein.	0.402
B2M	KLRD1	A0A340Y6E3	A0A340YCD1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Natural killer cells antigen CD94.	0.496
B2M	LOC103070953	A0A340Y6E3	A0A340WBK4	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.900
BTK	FYN	A0A340Y974	A0A340WT33	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.521
BTK	GRAP2	A0A340Y974	A0A340X4H9	Tyrosine-protein kinase.	GRB2-related adapter protein 2.	0.719
BTK	GRB2	A0A340Y974	A0A340X5P7	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2 isoform X1.	0.797
BTK	LAT	A0A340Y974	A0A340X0N9	Tyrosine-protein kinase.	Linker for activation of T-cells family member 1.	0.485
BTK	LCK	A0A340Y974	A0A340YBD8	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.518
BTK	LCP2	A0A340Y974	A0A340WE85	Tyrosine-protein kinase.	Lymphocyte cytosolic protein 2.	0.980
BTK	PIK3CA	A0A340Y974	A0A340Y0D6	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.948
BTK	PIK3CB	A0A340Y974	A0A340XZ14	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.938
BTK	PIK3R1	A0A340Y974	A0A340X6G2	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.937
BTK	PIK3R2	A0A340Y974	A0A340XLU5	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.931
BTK	PLCG1	A0A340Y974	A0A340XU67	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.971
BTK	PLCG2	A0A340Y974	A0A340WY66	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.991
BTK	SHC1	A0A340Y974	A0A340X9E5	Tyrosine-protein kinase.	SHC-transforming protein 1 isoform X1.	0.611
BTK	SOS1	A0A340Y974	A0A340WF86	Tyrosine-protein kinase.	Son of sevenless homolog 1.	0.458
BTK	SYK	A0A340Y974	A0A340WDP8	Tyrosine-protein kinase.	Tyrosine-protein kinase SYK isoform X1.	0.973
BTK	TYROBP	A0A340Y974	A0A340YDK2	Tyrosine-protein kinase.	TYRO protein tyrosine kinase-binding protein isoform X1.	0.498
BTK	VAV2	A0A340Y974	A0A340WUJ4	Tyrosine-protein kinase.	Guanine nucleotide exchange factor VAV2 isoform X1.	0.714