STRINGSTRING
TIAM1 TIAM1 EPHA5 EPHA5 ACTB ACTB SRC SRC RHOA RHOA LOC103090824 LOC103090824 WASL WASL EFNB1 EFNB1 ACTR3B ACTR3B PSENEN PSENEN EPHB3 EPHB3 ITSN1 ITSN1 EPHB4 EPHB4 EPHB6 EPHB6 EPHA3 EPHA3 HRAS HRAS EPHA4 EPHA4 LOC103076856 LOC103076856 APH1B APH1B EPHA1 EPHA1 FNDC3B FNDC3B PTK2 PTK2 EFNB2 EFNB2 PAK3 PAK3 FNDC3A FNDC3A ACTR2 ACTR2 CFL2 CFL2 LOC103069126 LOC103069126 PAK2 PAK2 SDCBP2 SDCBP2 SDCBP SDCBP LYN LYN FMN1 FMN1 EPHA7 EPHA7 PSEN2 PSEN2 LOC103087660 LOC103087660 APH1A APH1A CFL1 CFL1 PAK1 PAK1 ACTG1 ACTG1 NCSTN NCSTN EPHA6 EPHA6 DSTN DSTN EPHA2 EPHA2 CDC42 CDC42 EPHA8 EPHA8 EPHB2 EPHB2 GRIN1 GRIN1 PSEN1 PSEN1 MMP2 MMP2 ACTL8 ACTL8 YES1 YES1 EFNA2 EFNA2 ARHGEF28 ARHGEF28 EFNA1 EFNA1 EFNB3 EFNB3 ROCK2 ROCK2 EFNA3 EFNA3 LOC103088639 LOC103088639 EFNA4 EFNA4 EPHB1 EPHB1 NCK2 NCK2 EPHA10 EPHA10 ARHGEF7 ARHGEF7 EFNA5 EFNA5 GRIN2B GRIN2B LIMK2 LIMK2 SDC2 SDC2 LOC103072471 LOC103072471 ARPC4 ARPC4 VAV2 VAV2 GIT1 GIT1 ARPC5L ARPC5L FYN FYN MMP9 MMP9 ARPC2 ARPC2 ARPC3 ARPC3 LOC103082455 LOC103082455 RAC1 RAC1 ARPC1A ARPC1A VAV3 VAV3 ARPC5 ARPC5 RASA1 RASA1 ARPC1B ARPC1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1592 aa)
EPHA5Ephrin type-A receptor 5-like isoform X1. (1037 aa)
ACTBActin, cytoplasmic 1. (375 aa)
SRCTyrosine-protein kinase. (548 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
LOC103090824Formin-2-like. (1322 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (505 aa)
EFNB1ephrin-B1; Belongs to the ephrin family. (346 aa)
ACTR3BActin-related protein 3B-like isoform X1; Belongs to the actin family. (418 aa)
PSENENGamma-secretase subunit PEN-2. (101 aa)
EPHB3Ephrin type-B receptor 3. (1005 aa)
ITSN1Intersectin-1-like. (616 aa)
EPHB4Ephrin type-B receptor 4. (987 aa)
EPHB6Ephrin type-B receptor 6. (1011 aa)
EPHA3Ephrin type-A receptor 3-like isoform X1. (984 aa)
HRASGTPase HRas isoform X1. (189 aa)
EPHA4Ephrin type-A receptor 4-like isoform X1. (986 aa)
LOC103076856Cofilin-1-like; Belongs to the actin-binding proteins ADF family. (262 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
EPHA1Ephrin type-A receptor 1. (981 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
EFNB2ephrin-B2; Belongs to the ephrin family. (333 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (579 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
CFL2Cofilin-2 isoform X1; Belongs to the actin-binding proteins ADF family. (166 aa)
LOC103069126Actin-related protein 3-like isoform X1; Belongs to the actin family. (418 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
SDCBP2Syntenin-2. (313 aa)
SDCBPSyntenin-1 isoform X1. (298 aa)
LYNTyrosine-protein kinase. (516 aa)
FMN1Formin-1 isoform X1. (1420 aa)
EPHA7Ephrin type-A receptor 7-like isoform X1. (998 aa)
PSEN2Presenilin-2. (407 aa)
LOC103087660Ephexin-1-like. (433 aa)
APH1AGamma-secretase subunit APH-1A isoform X1. (340 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
NCSTNNicastrin isoform X1. (709 aa)
EPHA6Ephrin type-A receptor 6. (1129 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
EPHA8Ephrin type-A receptor 8. (979 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (964 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (959 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
MMP272 kDa type IV collagenase. (584 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
YES1Tyrosine-protein kinase. (541 aa)
EFNA2ephrin-A2; Belongs to the ephrin family. (214 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1390 aa)
EFNA1ephrin-A1; Belongs to the ephrin family. (242 aa)
EFNB3LOW QUALITY PROTEIN: ephrin-B3; Belongs to the ephrin family. (356 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
EFNA3ephrin-A3 isoform X1; Belongs to the ephrin family. (238 aa)
LOC103088639Myosin regulatory light polypeptide 9-like isoform X1. (178 aa)
EFNA4ephrin-A4 isoform X1; Belongs to the ephrin family. (204 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
NCK2Cytoplasmic protein. (376 aa)
EPHA10LOW QUALITY PROTEIN: ephrin type-A receptor 10. (1007 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X2. (803 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (228 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1496 aa)
LIMK2LIM domain kinase 2 isoform X1. (638 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
LOC103072471Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (206 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (170 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
FYNTyrosine-protein kinase. (537 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (387 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
RASA1Ras GTPase-activating protein 1. (1040 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.