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| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | ZNF385C | Zinc finger protein 385C. (504 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | SETD8 | N-lysine methyltransferase SETD8. (322 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2633 aa) |
| | CSNK2A1 | Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (391 aa) |
| | TPX2 | Targeting protein for Xklp2 isoform X1. (747 aa) |
| | PML | Protein PML. (848 aa) |
| | RFFL | E3 ubiquitin-protein ligase rififylin isoform X1. (392 aa) |
| | LOC103072441 | Tumor protein p53-inducible nuclear protein 2-like. (180 aa) |
| | LOC103088774 | Tumor protein p53-inducible nuclear protein 2-like. (220 aa) |
| | PHF20 | PHD finger protein 20. (1013 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (892 aa) |
| | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2. (272 aa) |
| | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 isoform X3. (482 aa) |
| | CDK5R2 | Cyclin-dependent kinase 5 activator. (369 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa) |
| | ATRIP | LOW QUALITY PROTEIN: ATR-interacting protein. (794 aa) |
| | TP53RK | TP53-regulating kinase. (253 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |
| | TAF15 | TATA-binding protein-associated factor 2N. (529 aa) |
| | TBP | TATA-box-binding protein isoform X1. (329 aa) |
| | TBPL2 | TATA box-binding protein-like protein 2. (343 aa) |
| | UBB | polyubiquitin-C isoform X1. (305 aa) |
| | STK11 | Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (438 aa) |
| | TAF12 | Transcription initiation factor TFIID subunit 12 isoform X1. (161 aa) |
| | UBA52 | ubiquitin-60S ribosomal protein L40. (128 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | MTA2 | Metastasis-associated protein MTA2. (666 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | HIPK1 | Homeodomain-interacting protein kinase 1. (1209 aa) |
| | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1. (877 aa) |
| | DYRK2 | LOW QUALITY PROTEIN: dual specificity tyrosine-phosphorylation-regulated kinase 2. (600 aa) |
| | TMEM55B | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (367 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | CCNA2 | cyclin-A2; Belongs to the cyclin family. (432 aa) |
| | RMI2 | recQ-mediated genome instability protein 2. (149 aa) |
| | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1. (270 aa) |
| | TXNDC11 | Thioredoxin domain-containing protein 11. (958 aa) |
| | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta. (370 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | AURKA | Aurora kinase A isoform X1; Belongs to the protein kinase superfamily. (422 aa) |
| | RPS27A | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | TAF3 | Transcription initiation factor TFIID subunit 3. (920 aa) |
| | CCNA1 | cyclin-A1; Belongs to the cyclin family. (421 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1224 aa) |
| | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (644 aa) |
| | POU4F1 | POU domain protein. (388 aa) |
| | PRDM1 | PR domain zinc finger protein 1 isoform X1. (826 aa) |
| | BRIP1 | LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1241 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | RICTOR | Rapamycin-insensitive companion of mTOR-like isoform X1. (1580 aa) |
| | RMI1 | recQ-mediated genome instability protein 1 isoform X1. (626 aa) |
| | HIPK3 | Homeodomain-interacting protein kinase 3 isoform X1. (1212 aa) |
| | ZNF385A | Zinc finger protein 385A isoform X1. (386 aa) |
| | CSNK2A2 | Casein kinase II subunit alpha. (213 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | TAF11 | Transcription initiation factor TFIID subunit 11 isoform X1. (211 aa) |
| | HIPK2 | Homeodomain-interacting protein kinase 2 isoform X1. (1180 aa) |
| | TAF6 | Transcription initiation factor TFIID subunit 6. (678 aa) |
| | BANP | Protein BANP isoform X2. (506 aa) |
| | LOC103073470 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) |
| | HDAC1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (538 aa) |
| | LOC103076597 | ubiquitin-40S ribosomal protein S27a-like. (187 aa) |
| | BRPF3 | Bromodomain and PHD finger-containing protein 3. (1210 aa) |
| | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1. (240 aa) |
| | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1. (421 aa) |
| | ANKRD11 | Ankyrin repeat domain-containing protein 11. (2610 aa) |
| | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa) |
| | TAF7L | Transcription initiation factor TFIID subunit 7-like. (469 aa) |
| | RBBP4 | Histone-binding protein RBBP4 isoform X1. (425 aa) |
| | CDK2 | Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa) |
| | ING5 | Inhibitor of growth protein. (240 aa) |
| | TAF5 | Transcription initiation factor TFIID subunit 5 isoform X1. (800 aa) |
| | CDK5 | Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa) |
| | DYRK3 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1. (616 aa) |
| | RFC2 | Replication factor C subunit 2 isoform X1. (352 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) |
| | MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa) |
| | ANKRD32 | Ankyrin repeat domain-containing protein 32 isoform X2. (1055 aa) |
| | USP7 | Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1107 aa) |
| | CHD4 | chromodomain-helicase-DNA-binding protein 4. (1912 aa) |
| | DYRK4 | Dual specificity tyrosine-phosphorylation-regulated kinase 4. (189 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1430 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | NUAK2 | NUAK family SNF1-like kinase 2. (633 aa) |
| | BRD9 | Bromodomain-containing protein 9. (596 aa) |
| | JMY | Junction-mediating and -regulatory protein. (993 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | LOC103075745 | Tudor domain-containing protein 3-like isoform X1. (651 aa) |
| | TTC5 | Tetratricopeptide repeat protein 5. (458 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2 isoform X1. (547 aa) |
| | TAF4 | Transcription initiation factor TFIID subunit 4. (883 aa) |
| | LOC103088198 | Histone-lysine N-methyltransferase EHMT2-like. (210 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | LY6G5B | Lymphocyte antigen 6 complex locus protein G5b. (218 aa) |
| | EHMT2 | Histone-lysine N-methyltransferase EHMT2-like isoform X1. (1209 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit 1-like. (1452 aa) |
| | ING3 | Inhibitor of growth protein. (437 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1312 aa) |
| | GATAD2A | Transcriptional repressor p66-alpha. (639 aa) |
| | KXD1 | kxDL motif-containing protein 1. (176 aa) |
| | HIPK4 | Homeodomain-interacting protein kinase 4. (610 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (249 aa) |
| | DAXX | Death domain-associated protein 6. (757 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | MBD3 | methyl-CpG-binding domain protein 3 isoform X1. (289 aa) |
| | AURKB | Aurora kinase B isoform X1; Belongs to the protein kinase superfamily. (345 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1471 aa) |
| | TMEM55A | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa) |
| | FOXP4 | Forkhead box protein P4 isoform X1. (680 aa) |
| | BRD7 | Bromodomain-containing protein 7 isoform X1. (652 aa) |
| | GATAD2B | Transcriptional repressor p66-beta. (592 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa) |
| | EHMT1 | Histone-lysine N-methyltransferase EHMT1. (1265 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (709 aa) |
| | TAF4B | Transcription initiation factor TFIID subunit 4B isoform X1. (861 aa) |
| | PPP1R13L | relA-associated inhibitor isoform X1. (828 aa) |
| | LOC103082213 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like isoform X1. (589 aa) |
| | CHD3 | chromodomain-helicase-DNA-binding protein 3. (1986 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa) |
| | ING1 | Inhibitor of growth protein. (278 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2087 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (281 aa) |
| | RFC5 | Replication factor C subunit 5. (342 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | RBBP7 | Histone-binding protein RBBP7 isoform X1. (469 aa) |
| | TAF9 | Transcription initiation factor TFIID subunit 9 isoform X1. (265 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) |
| | LOC103072950 | Uncharacterized protein LOC103072950. (442 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1 isoform X1. (776 aa) |
| | CCNG1 | cyclin-G1 isoform X1; Belongs to the cyclin family. (295 aa) |
| | BRD1 | Bromodomain-containing protein 1 isoform X2. (1187 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform X1. (471 aa) |
| | PRR5 | Proline-rich protein 5. (388 aa) |
| | PPP1R13B | Apoptosis-stimulating of p53 protein 1. (1072 aa) |
| | TP53BP2 | Apoptosis-stimulating of p53 protein 2 isoform X1. (1136 aa) |
| | PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (406 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (623 aa) |
| | CDK3 | Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | EP300 | Histone acetyltransferase p300. (2420 aa) |
| | AIRE | Autoimmune regulator. (562 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (350 aa) |
| | LOC103084951 | Transcription initiation factor TFIID subunit 7-like. (349 aa) |
| | TAF2 | Transcription initiation factor TFIID subunit 2. (1103 aa) |
| | MEAF6 | Chromatin modification-related protein MEAF6 isoform X3. (192 aa) |
| | LOC103076438 | ubiquitin-40S ribosomal protein S27a-like. (155 aa) |
| | TBPL1 | TATA box-binding protein-like protein 1. (186 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase. (527 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | CHD5 | chromodomain-helicase-DNA-binding protein 5. (1817 aa) |
| | TP53INP1 | Tumor protein p53-inducible nuclear protein 1 isoform X1. (240 aa) |
| | SETD9 | SET domain-containing protein 9. (299 aa) |
| | SMYD2 | N-lysine methyltransferase SMYD2. (433 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (419 aa) |
| | HDAC2 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa) |
| | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 isoform X2. (336 aa) |
| | MRE11A | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | BRPF1 | Peregrin isoform X1. (1220 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa) |
| | SUPT16H | FACT complex subunit SPT16. (1047 aa) |
| | POU4F3 | POU domain protein. (338 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | ZNF385B | Zinc finger protein 385B. (478 aa) |
| | NOC2L | Nucleolar complex protein 2 homolog. (702 aa) |
| | LOC103083100 | ubiquitin-60S ribosomal protein L40-like. (116 aa) |
| | TAF13 | Transcription initiation factor TFIID subunit 13. (124 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa) |
| | UBC | polyubiquitin-C. (462 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (647 aa) |
| | CDK1 | Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa) |
| | NUAK1 | NUAK family SNF1-like kinase 1. (666 aa) |
| | MAPKAPK5 | MAP kinase-activated protein kinase 5 isoform X1. (473 aa) |
| | RNF34 | E3 ubiquitin-protein ligase RNF34. (374 aa) |
| | L3MBTL3 | Lethal(3)malignant brain tumor-like protein 3 isoform X1. (780 aa) |
| | PHF20L1 | PHD finger protein 20-like protein 1 isoform X1. (1017 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa) |
| | L3MBTL4 | Lethal(3)malignant brain tumor-like protein 4. (1078 aa) |
| | TAF9B | Transcription initiation factor TFIID subunit 9B. (250 aa) |
| | LOC103081641 | LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (638 aa) |
