STRINGSTRING
MAPK3 MAPK3 RPS27A RPS27A FGF9 FGF9 FRS2 FRS2 MKNK1 MKNK1 FGFR4 FGFR4 PLCG1 PLCG1 UBA52 UBA52 PPP2CA PPP2CA NRAS NRAS LOC103081170 LOC103081170 FNDC3A FNDC3A SPRY2 SPRY2 FNDC3B FNDC3B PIK3CA PIK3CA FGF4 FGF4 FGF18 FGF18 HRAS HRAS BRAF BRAF FGF1 FGF1 LOC103076597 LOC103076597 FGF6 FGF6 FGF23 FGF23 FGF2 FGF2 PTPN11 PTPN11 FGF8 FGF8 MKNK2 MKNK2 UBB UBB CSDE1 CSDE1 FGF20 FGF20 FRS3 FRS3 SHC1 SHC1 PIK3R1 PIK3R1 GRB2 GRB2 LOC103072950 LOC103072950 CBL CBL LOC103076438 LOC103076438 FGF17 FGF17 KLB KLB LOC103083100 LOC103083100 UBC UBC MAPK1 MAPK1 ERAS ERAS PPP2CB PPP2CB SOS1 SOS1 SRC SRC FGF16 FGF16 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase. (325 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (435 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
NRASGTPase NRas. (189 aa)
LOC103081170Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (465 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
SPRY2Protein sprouty homolog 2 isoform X1. (315 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HRASGTPase HRas isoform X1. (189 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
LOC103076597ubiquitin-40S ribosomal protein S27a-like. (187 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (463 aa)
UBBpolyubiquitin-C isoform X1. (305 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (843 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FRS3Fibroblast growth factor receptor substrate 3 isoform X1. (495 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
LOC103072950Uncharacterized protein LOC103072950. (442 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
LOC103076438ubiquitin-40S ribosomal protein S27a-like. (155 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1042 aa)
LOC103083100ubiquitin-60S ribosomal protein L40-like. (116 aa)
UBCpolyubiquitin-C. (462 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
ERASGTPase ERas. (233 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
SRCTyrosine-protein kinase. (548 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
KRASGTPase KRas. (188 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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