STRINGSTRING
ATR ATR HUS1 HUS1 RAD51C RAD51C WRN WRN RFC1 RFC1 POLD3 POLD3 RNF169 RNF169 LOC103071163 LOC103071163 UBC UBC RAD9B RAD9B POLD4 POLD4 LOC103083100 LOC103083100 RAD51B RAD51B RPA3 RPA3 POLE3 POLE3 MDC1 MDC1 LOC103070340 LOC103070340 LOC103071989 LOC103071989 LOC103073911 LOC103073911 MRE11A MRE11A BRCA1 BRCA1 PALB2 PALB2 PCNA PCNA POLQ POLQ RAD9A RAD9A RFC4 RFC4 SLX4 SLX4 ABL1 ABL1 LOC103076438 LOC103076438 LOC103073202 LOC103073202 PARP3 PARP3 CDK3 CDK3 EXD2 EXD2 PPP4C PPP4C POLE4 POLE4 LOC103074048 LOC103074048 SLX1A SLX1A UBE2I UBE2I EME2 EME2 MEIOB MEIOB BARD1 BARD1 LOC103072950 LOC103072950 RPA1 RPA1 POLE POLE RFC5 RFC5 XRCC3 XRCC3 RAD17 RAD17 XRCC1 XRCC1 DNA2 DNA2 POLH POLH TOPBP1 TOPBP1 ERCC1 ERCC1 KXD1 KXD1 RAD50 RAD50 POLK POLK MUS81 MUS81 RAD51 RAD51 LOC103075745 LOC103075745 EXO1 EXO1 UBB UBB SIRT6 SIRT6 UIMC1 UIMC1 UBA52 UBA52 KAT5 KAT5 FEN1 FEN1 SIRT7 SIRT7 CHEK1 CHEK1 PARP1 PARP1 BRCA2 BRCA2 GEN1 GEN1 LOC103081255 LOC103081255 PARP2 PARP2 CCNA2 CCNA2 RMI2 RMI2 EME1 EME1 RFC3 RFC3 POLD1 POLD1 LOC103080427 LOC103080427 LOC103081704 LOC103081704 RPS27A RPS27A SPIDR SPIDR CCNA1 CCNA1 RECQL4 RECQL4 BRIP1 BRIP1 RNF8 RNF8 RMI1 RMI1 RCBTB1 RCBTB1 RCBTB2 RCBTB2 LOC103073470 LOC103073470 RAD1 RAD1 TIMELESS TIMELESS LOC103076597 LOC103076597 RHNO1 RHNO1 ANKRD11 ANKRD11 CDK2 CDK2 LOC103068403 LOC103068403 UBE2N UBE2N LOC103068676 LOC103068676 RFC2 RFC2 XRCC2 XRCC2 RAD51AP1 RAD51AP1 LOC103079101 LOC103079101 LOC103082925 LOC103082925 ANKRD32 ANKRD32 RAD52 RAD52 LOC103076894 LOC103076894 LOC103086798 LOC103086798 BLM BLM LOC103076624 LOC103076624 LOC103080666 LOC103080666 LOC103085965 LOC103085965 ATM ATM POLD2 POLD2 LOC103089819 LOC103089819 RAD51D RAD51D PPP4R2 PPP4R2 RBBP8 RBBP8 TOP3A TOP3A NBN NBN ATRIP ATRIP TIPIN TIPIN LIG3 LIG3 LOC103070587 LOC103070587 POLE2 POLE2 LOC103076219 LOC103076219
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2633 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
RAD51CDNA repair protein RAD51 homolog 3. (337 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa)
RFC1Replication factor C subunit 1. (1245 aa)
POLD3DNA polymerase delta subunit 3. (469 aa)
RNF169E3 ubiquitin-protein ligase RNF169. (708 aa)
LOC103071163Histone H2B; Belongs to the histone H2B family. (126 aa)
UBCpolyubiquitin-C. (462 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
POLD4DNA polymerase delta subunit 4. (107 aa)
LOC103083100ubiquitin-60S ribosomal protein L40-like. (116 aa)
RAD51BDNA repair protein RAD51 homolog 2. (252 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
MDC1Mediator of DNA damage checkpoint protein 1. (2091 aa)
LOC103070340Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103071989Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103073911Histone H2B; Belongs to the histone H2B family. (126 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa)
PALB2Partner and localizer of BRCA2. (1192 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLQLOW QUALITY PROTEIN: DNA polymerase theta. (2603 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (419 aa)
RFC4Replication factor C subunit 4. (364 aa)
SLX4LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4. (1776 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
LOC103076438ubiquitin-40S ribosomal protein S27a-like. (155 aa)
LOC103073202Mitochondrial DNA repair protein recA homolog; Belongs to the RecA family. (352 aa)
PARP3Poly [ADP-ribose] polymerase. (536 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (623 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
POLE4DNA polymerase epsilon subunit 4. (116 aa)
LOC103074048Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (271 aa)
UBE2ISUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
EME2LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2. (377 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (471 aa)
BARD1BRCA1-associated RING domain protein 1 isoform X1. (776 aa)
LOC103072950Uncharacterized protein LOC103072950. (442 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
RFC5Replication factor C subunit 5. (342 aa)
XRCC3DNA repair protein XRCC3. (346 aa)
RAD17Cell cycle checkpoint protein RAD17. (709 aa)
XRCC1DNA repair protein XRCC1. (628 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa)
POLHDNA polymerase eta isoform X1. (803 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1471 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (294 aa)
KXD1kxDL motif-containing protein 1. (176 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
POLKDNA polymerase kappa. (885 aa)
MUS81Crossover junction endonuclease MUS81. (551 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
LOC103075745Tudor domain-containing protein 3-like isoform X1. (651 aa)
EXO1Exonuclease 1. (835 aa)
UBBpolyubiquitin-C isoform X1. (305 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X1. (359 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (726 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (400 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
GEN1Flap endonuclease GEN homolog 1. (905 aa)
LOC103081255Histone H2B; Belongs to the histone H2B family. (142 aa)
PARP2Poly [ADP-ribose] polymerase. (591 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
RMI2recQ-mediated genome instability protein 2. (149 aa)
EME1Crossover junction endonuclease EME1 isoform X1. (589 aa)
RFC3Replication factor C subunit 3. (356 aa)
POLD1DNA polymerase. (1107 aa)
LOC103080427Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081704Histone H2B; Belongs to the histone H2B family. (126 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
SPIDRDNA repair-scaffolding protein. (1021 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
RECQL4ATP-dependent DNA helicase Q4. (1224 aa)
BRIP1LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1241 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
RMI1recQ-mediated genome instability protein 1 isoform X1. (626 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (572 aa)
LOC103073470Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
TIMELESSProtein timeless homolog. (1202 aa)
LOC103076597ubiquitin-40S ribosomal protein S27a-like. (187 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1. (240 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2610 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
LOC103068403Histone H2B type W-T-like; Belongs to the histone H2B family. (184 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC103068676Histone H2B type W-T-like; Belongs to the histone H2B family. (177 aa)
RFC2Replication factor C subunit 2 isoform X1. (352 aa)
XRCC2DNA repair protein XRCC2-like. (280 aa)
RAD51AP1RAD51-associated protein 1. (332 aa)
LOC103079101Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103082925Histone H2B; Belongs to the histone H2B family. (126 aa)
ANKRD32Ankyrin repeat domain-containing protein 32 isoform X2. (1055 aa)
RAD52LOW QUALITY PROTEIN: DNA repair protein RAD52 homolog. (407 aa)
LOC103076894Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103086798Histone H2B; Belongs to the histone H2B family. (126 aa)
BLMBloom syndrome protein isoform X1. (1430 aa)
LOC103076624Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103080666Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103085965Histone H2B; Belongs to the histone H2B family. (126 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
POLD2DNA polymerase delta subunit 2 isoform X1. (469 aa)
LOC103089819Mitochondrial DNA repair protein recA homolog; Belongs to the RecA family. (463 aa)
RAD51DDNA repair protein RAD51 homolog 4. (350 aa)
PPP4R2Serine/threonine-protein phosphatase 4 regulatory subunit 2. (409 aa)
RBBP8DNA endonuclease RBBP8. (892 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
ATRIPLOW QUALITY PROTEIN: ATR-interacting protein. (794 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (309 aa)
LIG3DNA ligase. (1013 aa)
LOC103070587Tyrosine-protein kinase ABL1-like. (126 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
LOC103076219DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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