STRINGSTRING
LOC103068676 LOC103068676 UBA52 UBA52 KAT5 KAT5 LOC103084799 LOC103084799 LOC103081255 LOC103081255 LOC103080427 LOC103080427 LOC103081704 LOC103081704 RPS27A RPS27A LOC103076307 LOC103076307 RNF168 RNF168 UBE2V2 UBE2V2 TP53BP1 TP53BP1 RNF8 RNF8 BRCC3 BRCC3 KDM4A KDM4A LOC103073470 LOC103073470 LOC103076597 LOC103076597 WHSC1 WHSC1 ANKRD11 ANKRD11 LOC103068403 LOC103068403 UBE2N UBE2N SUMO1 SUMO1 LOC103085965 LOC103085965 EYA2 EYA2 ATM ATM LOC103070587 LOC103070587 NBN NBN FAM175A FAM175A RNF169 RNF169 LOC103083828 LOC103083828 LOC103071163 LOC103071163 UBC UBC LOC103083100 LOC103083100 MDC1 MDC1 LOC103070340 LOC103070340 LOC103071989 LOC103071989 LOC103073911 LOC103073911 BAP1 BAP1 MRE11A MRE11A BRCA1 BRCA1 LOC103074978 LOC103074978 BRE BRE LOC103080666 LOC103080666 LOC103076624 LOC103076624 LOC103074679 LOC103074679 LOC103086798 LOC103086798 LOC103076894 LOC103076894 LOC103088169 LOC103088169 LOC103082925 LOC103082925 LOC103081667 LOC103081667 LOC103079101 LOC103079101 LOC103076354 LOC103076354 EYA4 EYA4 APBB2 APBB2 ABL1 ABL1 LOC103076438 LOC103076438 LOC103074048 LOC103074048 UBE2I UBE2I BARD1 BARD1 LOC103070012 LOC103070012 LOC103072950 LOC103072950 LOC103090400 LOC103090400 PPP5C PPP5C EYA3 EYA3 TP53 TP53 LOC103070113 LOC103070113 EYA1 EYA1 KXD1 KXD1 APBB1 APBB1 RAD50 RAD50 KDM4B KDM4B UBXN1 UBXN1 BABAM1 BABAM1 CHEK2 CHEK2 UBB UBB PIAS4 PIAS4 UIMC1 UIMC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103068676Histone H2B type W-T-like; Belongs to the histone H2B family. (177 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
LOC103084799Lys-63-specific deubiquitinase BRCC36-like. (139 aa)
LOC103081255Histone H2B; Belongs to the histone H2B family. (142 aa)
LOC103080427Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081704Histone H2B; Belongs to the histone H2B family. (126 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
LOC103076307LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2-like. (4837 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
TP53BP1Tumor suppressor p53-binding protein 1 isoform X1. (1975 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (183 aa)
KDM4ALOW QUALITY PROTEIN: lysine-specific demethylase 4A. (1069 aa)
LOC103073470Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa)
LOC103076597ubiquitin-40S ribosomal protein S27a-like. (187 aa)
WHSC1Histone-lysine N-methyltransferase NSD2 isoform X1. (1358 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2610 aa)
LOC103068403Histone H2B type W-T-like; Belongs to the histone H2B family. (184 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
LOC103085965Histone H2B; Belongs to the histone H2B family. (126 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (537 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
LOC103070587Tyrosine-protein kinase ABL1-like. (126 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
FAM175ABRCA1-A complex subunit Abraxas. (410 aa)
RNF169E3 ubiquitin-protein ligase RNF169. (708 aa)
LOC103083828E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
LOC103071163Histone H2B; Belongs to the histone H2B family. (126 aa)
UBCpolyubiquitin-C. (462 aa)
LOC103083100ubiquitin-60S ribosomal protein L40-like. (116 aa)
MDC1Mediator of DNA damage checkpoint protein 1. (2091 aa)
LOC103070340Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103071989Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103073911Histone H2B; Belongs to the histone H2B family. (126 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa)
LOC103074978Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
BREBRCA1-A complex subunit BRE isoform X1. (407 aa)
LOC103080666Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103076624Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103074679Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC103086798Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103076894Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103088169Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC103082925Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081667Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103079101Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103076354Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (570 aa)
APBB2Amyloid beta A4 precursor protein-binding family B member 2 isoform X1. (758 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
LOC103076438ubiquitin-40S ribosomal protein S27a-like. (155 aa)
LOC103074048Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
UBE2ISUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
BARD1BRCA1-associated RING domain protein 1 isoform X1. (776 aa)
LOC103070012Small ubiquitin-related modifier. (101 aa)
LOC103072950Uncharacterized protein LOC103072950. (442 aa)
LOC103090400Histone H2B; Belongs to the histone H2B family. (126 aa)
PPP5CSerine/threonine-protein phosphatase. (499 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
LOC103070113Small ubiquitin-related modifier. (117 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (594 aa)
KXD1kxDL motif-containing protein 1. (176 aa)
APBB1Amyloid beta A4 precursor protein-binding family B member 1 isoform X1. (708 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
KDM4BLysine-specific demethylase 4B. (1088 aa)
UBXN1UBX domain-containing protein 1 isoform X1. (317 aa)
BABAM1BRISC and BRCA1-A complex member 1 isoform X1. (330 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (547 aa)
UBBpolyubiquitin-C isoform X1. (305 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (513 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (726 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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