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RPA3 | Replication protein A 14 kDa subunit. (121 aa) | ||||
LOC103085965 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC103080666 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC103076624 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
BLM | Bloom syndrome protein isoform X1. (1430 aa) | ||||
LOC103086798 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC103076894 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
RAD52 | LOW QUALITY PROTEIN: DNA repair protein RAD52 homolog. (407 aa) | ||||
ANKRD32 | Ankyrin repeat domain-containing protein 32 isoform X2. (1055 aa) | ||||
LOC103082925 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC103079101 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
RAD51AP1 | RAD51-associated protein 1. (332 aa) | ||||
XRCC2 | DNA repair protein XRCC2-like. (280 aa) | ||||
RFC2 | Replication factor C subunit 2 isoform X1. (352 aa) | ||||
LOC103068676 | Histone H2B type W-T-like; Belongs to the histone H2B family. (177 aa) | ||||
UBE2N | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) | ||||
LOC103068403 | Histone H2B type W-T-like; Belongs to the histone H2B family. (184 aa) | ||||
CDK2 | Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa) | ||||
ANKRD11 | Ankyrin repeat domain-containing protein 11. (2610 aa) | ||||
RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1. (240 aa) | ||||
LOC103076597 | ubiquitin-40S ribosomal protein S27a-like. (187 aa) | ||||
TIMELESS | Protein timeless homolog. (1202 aa) | ||||
RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) | ||||
LOC103073470 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa) | ||||
RCBTB2 | RCC1 and BTB domain-containing protein 2 isoform X1. (572 aa) | ||||
RCBTB1 | RCC1 and BTB domain-containing protein 1. (531 aa) | ||||
RMI1 | recQ-mediated genome instability protein 1 isoform X1. (626 aa) | ||||
RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa) | ||||
BRIP1 | LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1241 aa) | ||||
RECQL4 | ATP-dependent DNA helicase Q4. (1224 aa) | ||||
CCNA1 | cyclin-A1; Belongs to the cyclin family. (421 aa) | ||||
SPIDR | DNA repair-scaffolding protein. (1021 aa) | ||||
RPS27A | ubiquitin-40S ribosomal protein S27a. (156 aa) | ||||
LOC103081704 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC103080427 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
POLD1 | DNA polymerase. (1107 aa) | ||||
RFC3 | Replication factor C subunit 3. (356 aa) | ||||
EME1 | Crossover junction endonuclease EME1 isoform X1. (589 aa) | ||||
RMI2 | recQ-mediated genome instability protein 2. (149 aa) | ||||
CCNA2 | cyclin-A2; Belongs to the cyclin family. (432 aa) | ||||
LOC103081255 | Histone H2B; Belongs to the histone H2B family. (142 aa) | ||||
GEN1 | Flap endonuclease GEN homolog 1. (905 aa) | ||||
BRCA2 | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa) | ||||
CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa) | ||||
SIRT7 | NAD-dependent protein deacetylase sirtuin-7. (400 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) | ||||
UBA52 | ubiquitin-60S ribosomal protein L40. (128 aa) | ||||
UIMC1 | BRCA1-A complex subunit RAP80 isoform X1. (726 aa) | ||||
SIRT6 | NAD-dependent protein deacetylase sirtuin-6 isoform X1. (359 aa) | ||||
UBB | polyubiquitin-C isoform X1. (305 aa) | ||||
EXO1 | Exonuclease 1. (835 aa) | ||||
LOC103075745 | Tudor domain-containing protein 3-like isoform X1. (651 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
MUS81 | Crossover junction endonuclease MUS81. (551 aa) | ||||
POLK | DNA polymerase kappa. (885 aa) | ||||
RAD50 | DNA repair protein RAD50 isoform X1. (1312 aa) | ||||
KXD1 | kxDL motif-containing protein 1. (176 aa) | ||||
ERCC1 | DNA excision repair protein ERCC-1 isoform X1. (294 aa) | ||||
TOPBP1 | DNA topoisomerase 2-binding protein 1. (1471 aa) | ||||
POLH | DNA polymerase eta isoform X1. (803 aa) | ||||
DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa) | ||||
RAD17 | Cell cycle checkpoint protein RAD17. (709 aa) | ||||
XRCC3 | DNA repair protein XRCC3. (346 aa) | ||||
RFC5 | Replication factor C subunit 5. (342 aa) | ||||
POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) | ||||
RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa) | ||||
LOC103072950 | Uncharacterized protein LOC103072950. (442 aa) | ||||
BARD1 | BRCA1-associated RING domain protein 1 isoform X1. (776 aa) | ||||
MEIOB | Meiosis-specific with OB domain-containing protein isoform X1. (471 aa) | ||||
EME2 | LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2. (377 aa) | ||||
UBE2I | SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) | ||||
SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (271 aa) | ||||
LOC103074048 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa) | ||||
POLE4 | DNA polymerase epsilon subunit 4. (116 aa) | ||||
PPP4C | Serine/threonine-protein phosphatase. (307 aa) | ||||
EXD2 | Exonuclease 3'-5' domain-containing protein 2. (623 aa) | ||||
CDK3 | Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) | ||||
LOC103073202 | Mitochondrial DNA repair protein recA homolog; Belongs to the RecA family. (352 aa) | ||||
LOC103076438 | ubiquitin-40S ribosomal protein S27a-like. (155 aa) | ||||
ABL1 | Tyrosine-protein kinase. (1006 aa) | ||||
SLX4 | LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4. (1776 aa) | ||||
RFC4 | Replication factor C subunit 4. (364 aa) | ||||
RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (419 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
PALB2 | Partner and localizer of BRCA2. (1192 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa) | ||||
MRE11A | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) | ||||
LOC103073911 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC103071989 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
LOC103070340 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
MDC1 | Mediator of DNA damage checkpoint protein 1. (2091 aa) | ||||
POLE3 | DNA polymerase epsilon subunit 3. (147 aa) | ||||
RAD51B | DNA repair protein RAD51 homolog 2. (252 aa) | ||||
LOC103083100 | ubiquitin-60S ribosomal protein L40-like. (116 aa) | ||||
POLD4 | DNA polymerase delta subunit 4. (107 aa) | ||||
RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa) | ||||
UBC | polyubiquitin-C. (462 aa) | ||||
LOC103071163 | Histone H2B; Belongs to the histone H2B family. (126 aa) | ||||
RNF169 | E3 ubiquitin-protein ligase RNF169. (708 aa) | ||||
POLD3 | DNA polymerase delta subunit 3. (469 aa) | ||||
RFC1 | Replication factor C subunit 1. (1245 aa) | ||||
WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa) | ||||
RAD51C | DNA repair protein RAD51 homolog 3. (337 aa) | ||||
HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) | ||||
ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2633 aa) | ||||
LOC103076219 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
POLD2 | DNA polymerase delta subunit 2 isoform X1. (469 aa) | ||||
LOC103089819 | Mitochondrial DNA repair protein recA homolog; Belongs to the RecA family. (463 aa) | ||||
RAD51D | DNA repair protein RAD51 homolog 4. (350 aa) | ||||
PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2. (409 aa) | ||||
RBBP8 | DNA endonuclease RBBP8. (892 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa) | ||||
ATRIP | LOW QUALITY PROTEIN: ATR-interacting protein. (794 aa) | ||||
TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (309 aa) | ||||
LOC103070587 | Tyrosine-protein kinase ABL1-like. (126 aa) | ||||
POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa) |