Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD11 | ATM | A0A340Y7W7 | A0A340WCK4 | Ankyrin repeat domain-containing protein 11. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.523 |
| ANKRD11 | ATRIP | A0A340Y7W7 | A0A340WF66 | Ankyrin repeat domain-containing protein 11. | LOW QUALITY PROTEIN: ATR-interacting protein. | 0.516 |
| ANKRD11 | BRCA1 | A0A340Y7W7 | A0A340WSA7 | Ankyrin repeat domain-containing protein 11. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.800 |
| ANKRD11 | BRIP1 | A0A340Y7W7 | A0A340Y076 | Ankyrin repeat domain-containing protein 11. | LOW QUALITY PROTEIN: Fanconi anemia group J protein. | 0.644 |
| ANKRD11 | DNA2 | A0A340Y7W7 | A0A340XBW4 | Ankyrin repeat domain-containing protein 11. | DNA replication ATP-dependent helicase/nuclease DNA2. | 0.517 |
| ANKRD11 | EXO1 | A0A340Y7W7 | A0A340XMS3 | Ankyrin repeat domain-containing protein 11. | Exonuclease 1. | 0.506 |
| ANKRD11 | HUS1 | A0A340Y7W7 | A0A340WJY1 | Ankyrin repeat domain-containing protein 11. | Checkpoint protein; Belongs to the HUS1 family. | 0.407 |
| ANKRD11 | LOC103073470 | A0A340Y7W7 | A0A340Y5J9 | Ankyrin repeat domain-containing protein 11. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.800 |
| ANKRD11 | LOC103074048 | A0A340Y7W7 | A0A340X140 | Ankyrin repeat domain-containing protein 11. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.434 |
| ANKRD11 | MDC1 | A0A340Y7W7 | A0A340WQC0 | Ankyrin repeat domain-containing protein 11. | Mediator of DNA damage checkpoint protein 1. | 0.446 |
| ANKRD11 | MRE11A | A0A340Y7W7 | A0A340WRY2 | Ankyrin repeat domain-containing protein 11. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.828 |
| ANKRD11 | NBN | A0A340Y7W7 | A0A340WFM1 | Ankyrin repeat domain-containing protein 11. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.812 |
| ANKRD11 | RAD1 | A0A340Y7W7 | A0A340Y5W8 | Ankyrin repeat domain-containing protein 11. | Cell cycle checkpoint protein RAD1. | 0.403 |
| ANKRD11 | RAD50 | A0A340Y7W7 | A0A340XJ04 | Ankyrin repeat domain-containing protein 11. | DNA repair protein RAD50 isoform X1. | 0.685 |
| ANKRD11 | RBBP8 | A0A340Y7W7 | A0A340WGE4 | Ankyrin repeat domain-containing protein 11. | DNA endonuclease RBBP8. | 0.885 |
| ANKRD11 | RFC2 | A0A340Y7W7 | A0A340YBM4 | Ankyrin repeat domain-containing protein 11. | Replication factor C subunit 2 isoform X1. | 0.400 |
| ANKRD11 | RFC3 | A0A340Y7W7 | A0A340XVU5 | Ankyrin repeat domain-containing protein 11. | Replication factor C subunit 3. | 0.407 |
| ANKRD11 | RFC4 | A0A340Y7W7 | A0A340WVC9 | Ankyrin repeat domain-containing protein 11. | Replication factor C subunit 4. | 0.412 |
| ANKRD11 | RMI1 | A0A340Y7W7 | A0A340Y2H1 | Ankyrin repeat domain-containing protein 11. | recQ-mediated genome instability protein 1 isoform X1. | 0.436 |
| ANKRD11 | RNF8 | A0A340Y7W7 | A0A340Y213 | Ankyrin repeat domain-containing protein 11. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.522 |
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