STRINGSTRING
PIK3CA PIK3CA COL3A1 COL3A1 HRAS HRAS HGF HGF LOC103076597 LOC103076597 PTPN11 PTPN11 SH3KBP1 SH3KBP1 LOC103088976 LOC103088976 HPN HPN SH3GL3 SH3GL3 SPINT2 SPINT2 ITGB1 ITGB1 SRC SRC KRAS KRAS LOC103076438 LOC103076438 LAMB3 LAMB3 LAMC3 LAMC3 ARF6 ARF6 RAPGEF1 RAPGEF1 LAMA2 LAMA2 LOC103082565 LOC103082565 LAMC2 LAMC2 CRKL CRKL LOC103083100 LOC103083100 RAP1A RAP1A SOS1 SOS1 LRIG1 LRIG1 PTPN1 PTPN1 TENC1 TENC1 RAB4A RAB4A STAT3 STAT3 MUC20 MUC20 RAC1 RAC1 MET MET ERAS ERAS LAMC1 LAMC1 UBC UBC LAMB2 LAMB2 RANBP9 RANBP9 RPS27A RPS27A TNS1 TNS1 CRK CRK PTPRJ PTPRJ CBL CBL LOC103072950 LOC103072950 GRB2 GRB2 GGA3 GGA3 PIK3R1 PIK3R1 LAMB1 LAMB1 USP8 USP8 SHC1 SHC1 FN1 FN1 HGFAC HGFAC RANBP10 RANBP10 SPINT1 SPINT1 SH3GL1 SH3GL1 STAM STAM RAB4B RAB4B EPS15 EPS15 CSDE1 CSDE1 UBB UBB UBA52 UBA52 RAP1B RAP1B TNS3 TNS3 PTPN2 PTPN2 HGS HGS DOCK7 DOCK7 NRAS NRAS COL5A2 COL5A2 TNS4 TNS4 STAM2 STAM2 FNDC3A FNDC3A PTK2 PTK2 SH3GL2 SH3GL2 FNDC3B FNDC3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
COL3A1Collagen alpha-1(III) chain-like. (1462 aa)
HRASGTPase HRas isoform X1. (189 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
LOC103076597ubiquitin-40S ribosomal protein S27a-like. (187 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X1. (665 aa)
LOC103088976Ras-related protein Rap-1b-like isoform X1. (165 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (417 aa)
SH3GL3endophilin-A3. (347 aa)
SPINT2Kunitz-type protease inhibitor 2. (225 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
SRCTyrosine-protein kinase. (548 aa)
KRASGTPase KRas. (188 aa)
LOC103076438ubiquitin-40S ribosomal protein S27a-like. (155 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
LAMC3Laminin subunit gamma-3. (1577 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa)
LAMA2Laminin subunit alpha-2 isoform X1. (3125 aa)
LOC103082565Kunitz-type protease inhibitor 2-like. (247 aa)
LAMC2Laminin subunit gamma-2. (1191 aa)
CRKLCrk-like protein. (303 aa)
LOC103083100ubiquitin-60S ribosomal protein L40-like. (116 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
LRIG1Leucine-rich repeats and immunoglobulin-like domains protein 1. (1110 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
TENC1Tensin-like C1 domain-containing phosphatase. (1371 aa)
RAB4ARas-related protein Rab-4A. (218 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
MUC20Mucin-20. (520 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
ERASGTPase ERas. (233 aa)
LAMC1LOW QUALITY PROTEIN: laminin subunit gamma-1. (1618 aa)
UBCpolyubiquitin-C. (462 aa)
LAMB2Laminin subunit beta-2. (1801 aa)
RANBP9Ran-binding protein 9-like. (387 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
TNS1Tensin-1 isoform X1. (1895 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta-like. (1155 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
LOC103072950Uncharacterized protein LOC103072950. (442 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
GGA3ADP-ribosylation factor-binding protein GGA3 isoform X1. (715 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
USP8LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1116 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
FN1LOW QUALITY PROTEIN: fibronectin. (2483 aa)
HGFACHepatocyte growth factor activator. (657 aa)
RANBP10Ran-binding protein 10. (620 aa)
SPINT1Kunitz-type protease inhibitor 1 isoform X1. (510 aa)
SH3GL1endophilin-A2 isoform X1. (369 aa)
STAMSignal transducing adapter molecule 1. (507 aa)
RAB4BRas-related protein Rab-4B isoform X2. (232 aa)
EPS15Epidermal growth factor receptor substrate 15. (902 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (843 aa)
UBBpolyubiquitin-C isoform X1. (305 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
TNS3Tensin-3-like. (1439 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X1; Belongs to the DOCK family. (2029 aa)
NRASGTPase NRas. (189 aa)
COL5A2Collagen alpha-2(V) chain. (1499 aa)
TNS4Tensin-4. (705 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (526 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
SH3GL2endophilin-A1. (352 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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