STRINGSTRING
HUS1 HUS1 ATM ATM ATRIP ATRIP NBN NBN TOP3A TOP3A RBBP8 RBBP8 ATR ATR FAM175A FAM175A WRN WRN RNF169 RNF169 LOC103083828 LOC103083828 CDK1 CDK1 LOC103071163 LOC103071163 RAD9B RAD9B RPA3 RPA3 MDC1 MDC1 LOC103070340 LOC103070340 LOC103071989 LOC103071989 LOC103073911 LOC103073911 MRE11A MRE11A BRCA1 BRCA1 LOC103074978 LOC103074978 RAD9A RAD9A RFC4 RFC4 YWHAH YWHAH YWHAE YWHAE EXD2 EXD2 LOC103074048 LOC103074048 MEIOB MEIOB BARD1 BARD1 RPA1 RPA1 YWHAQ YWHAQ CCNB1 CCNB1 RFC5 RFC5 LOC103090400 LOC103090400 RAD17 RAD17 DNA2 DNA2 TP53 TP53 TOPBP1 TOPBP1 SFN SFN RAD50 RAD50 CDC25C CDC25C BABAM1 BABAM1 CHEK2 CHEK2 LOC103075745 LOC103075745 EXO1 EXO1 PIAS4 PIAS4 UIMC1 UIMC1 KAT5 KAT5 CHEK1 CHEK1 LOC103084799 LOC103084799 LOC103084253 LOC103084253 LOC103081255 LOC103081255 RMI2 RMI2 RFC3 RFC3 LOC103080427 LOC103080427 LOC103081704 LOC103081704 LOC103076307 LOC103076307 YWHAB YWHAB YWHAZ YWHAZ RNF168 RNF168 UBE2V2 UBE2V2 RECQL4 RECQL4 BRIP1 BRIP1 TP53BP1 TP53BP1 RNF8 RNF8 BRCC3 BRCC3 RMI1 RMI1 WEE2 WEE2 LOC103073470 LOC103073470 RAD1 RAD1 WHSC1 WHSC1 LOC103074001 LOC103074001 RHNO1 RHNO1 ANKRD11 ANKRD11 LOC103068403 LOC103068403 UBE2N UBE2N LOC103068676 LOC103068676 RFC2 RFC2 LOC103076354 LOC103076354 LOC103079101 LOC103079101 LOC103081667 LOC103081667 LOC103082925 LOC103082925 LOC103088169 LOC103088169 ANKRD32 ANKRD32 LOC103076894 LOC103076894 LOC103086798 LOC103086798 WEE1 WEE1 BLM BLM LOC103074679 LOC103074679 LOC103076624 LOC103076624 LOC103080666 LOC103080666 BRE BRE LOC103085965 LOC103085965 YWHAG YWHAG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ATRIPLOW QUALITY PROTEIN: ATR-interacting protein. (794 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa)
RBBP8DNA endonuclease RBBP8. (892 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2633 aa)
FAM175ABRCA1-A complex subunit Abraxas. (410 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa)
RNF169E3 ubiquitin-protein ligase RNF169. (708 aa)
LOC103083828E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
CDK1Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
LOC103071163Histone H2B; Belongs to the histone H2B family. (126 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
MDC1Mediator of DNA damage checkpoint protein 1. (2091 aa)
LOC103070340Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103071989Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103073911Histone H2B; Belongs to the histone H2B family. (126 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa)
LOC103074978Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (419 aa)
RFC4Replication factor C subunit 4. (364 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (623 aa)
LOC103074048Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (471 aa)
BARD1BRCA1-associated RING domain protein 1 isoform X1. (776 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
CCNB1G2/mitotic-specific cyclin-B1 isoform X1; Belongs to the cyclin family. (433 aa)
RFC5Replication factor C subunit 5. (342 aa)
LOC103090400Histone H2B; Belongs to the histone H2B family. (126 aa)
RAD17Cell cycle checkpoint protein RAD17. (709 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1471 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
CDC25CM-phase inducer phosphatase 3. (477 aa)
BABAM1BRISC and BRCA1-A complex member 1 isoform X1. (330 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (547 aa)
LOC103075745Tudor domain-containing protein 3-like isoform X1. (651 aa)
EXO1Exonuclease 1. (835 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (513 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (726 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
LOC103084799Lys-63-specific deubiquitinase BRCC36-like. (139 aa)
LOC10308425314-3-3 protein gamma-like; Belongs to the 14-3-3 family. (245 aa)
LOC103081255Histone H2B; Belongs to the histone H2B family. (142 aa)
RMI2recQ-mediated genome instability protein 2. (149 aa)
RFC3Replication factor C subunit 3. (356 aa)
LOC103080427Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081704Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103076307LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2-like. (4837 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
YWHAZ14-3-3 protein zeta/delta isoform X1; Belongs to the 14-3-3 family. (245 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
RECQL4ATP-dependent DNA helicase Q4. (1224 aa)
BRIP1LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1241 aa)
TP53BP1Tumor suppressor p53-binding protein 1 isoform X1. (1975 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (183 aa)
RMI1recQ-mediated genome instability protein 1 isoform X1. (626 aa)
WEE2Wee1-like protein kinase. (572 aa)
LOC103073470Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
WHSC1Histone-lysine N-methyltransferase NSD2 isoform X1. (1358 aa)
LOC103074001LOW QUALITY PROTEIN: 14-3-3 protein zeta-like; Belongs to the 14-3-3 family. (230 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1. (240 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2610 aa)
LOC103068403Histone H2B type W-T-like; Belongs to the histone H2B family. (184 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC103068676Histone H2B type W-T-like; Belongs to the histone H2B family. (177 aa)
RFC2Replication factor C subunit 2 isoform X1. (352 aa)
LOC103076354Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103079101Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081667Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103082925Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103088169Histone H2B; Belongs to the histone H2B family. (127 aa)
ANKRD32Ankyrin repeat domain-containing protein 32 isoform X2. (1055 aa)
LOC103076894Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103086798Histone H2B; Belongs to the histone H2B family. (126 aa)
WEE1Wee1-like protein kinase. (861 aa)
BLMBloom syndrome protein isoform X1. (1430 aa)
LOC103074679Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC103076624Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103080666Histone H2B; Belongs to the histone H2B family. (126 aa)
BREBRCA1-A complex subunit BRE isoform X1. (407 aa)
LOC103085965Histone H2B; Belongs to the histone H2B family. (126 aa)
YWHAGLOW QUALITY PROTEIN: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma; Belongs to the 14-3-3 family. (247 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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