STRINGSTRING
ADPRHL2 ADPRHL2 LOC103074048 LOC103074048 LOC103080676 LOC103080676 ATAD5 ATAD5 POLE4 POLE4 TDG TDG MEIOB MEIOB MPG MPG RPA1 RPA1 POLE POLE POLB POLB RFC5 RFC5 ACD ACD LOC103090400 LOC103090400 XRCC1 XRCC1 VWA5B1 VWA5B1 MBD4 MBD4 APEX2 APEX2 FEN1 FEN1 PNKP PNKP APEX1 APEX1 TERF2IP TERF2IP PARP1 PARP1 LIG1 LIG1 LOC103079884 LOC103079884 LOC103081255 LOC103081255 PARP2 PARP2 RFC3 RFC3 POLD1 POLD1 LOC103080427 LOC103080427 LOC103081704 LOC103081704 LOC103081970 LOC103081970 LOC103089645 LOC103089645 RCBTB1 RCBTB1 RCBTB2 RCBTB2 SMUG1 SMUG1 LOC103068403 LOC103068403 LOC103068676 LOC103068676 RFC2 RFC2 VWA5B2 VWA5B2 LOC103076354 LOC103076354 LOC103079101 LOC103079101 LOC103081667 LOC103081667 LOC103082925 LOC103082925 LOC103088169 LOC103088169 NEIL2 NEIL2 LOC103076894 LOC103076894 LOC103080928 LOC103080928 LOC103086798 LOC103086798 LOC103074679 LOC103074679 LOC103076624 LOC103076624 LOC103080666 LOC103080666 LOC103088445 LOC103088445 LOC103077443 LOC103077443 LOC103085965 LOC103085965 PARP3 PARP3 TERF1 TERF1 OGG1 OGG1 NTHL1 NTHL1 RFC4 RFC4 MUTYH MUTYH PCNA PCNA LOC103074978 LOC103074978 LOC103073911 LOC103073911 LOC103071989 LOC103071989 TERF2 TERF2 LOC103071706 LOC103071706 LOC103070340 LOC103070340 POLE3 POLE3 RPA3 RPA3 POLD4 POLD4 LOC103071163 LOC103071163 POT1 POT1 UNG UNG POLD3 POLD3 TINF2 TINF2 RFC1 RFC1 LOC103079800 LOC103079800 POLD2 POLD2 PARG PARG LOC103074354 LOC103074354 LOC103079983 LOC103079983 LOC103089030 LOC103089030 NEIL1 NEIL1 LIG3 LIG3 POLE2 POLE2 NEIL3 NEIL3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADPRHL2poly(ADP-ribose) glycohydrolase ARH3. (365 aa)
LOC103074048Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
LOC103080676Histone H2A; Belongs to the histone H2A family. (129 aa)
ATAD5LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5. (1898 aa)
POLE4DNA polymerase epsilon subunit 4. (116 aa)
TDGG/T mismatch-specific thymine DNA glycosylase isoform X1. (405 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (471 aa)
MPGDNA-3-methyladenine glycosylase. (277 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
RFC5Replication factor C subunit 5. (342 aa)
ACDAdrenocortical dysplasia protein homolog. (454 aa)
LOC103090400Histone H2B; Belongs to the histone H2B family. (126 aa)
XRCC1DNA repair protein XRCC1. (628 aa)
VWA5B1LOW QUALITY PROTEIN: von Willebrand factor A domain-containing protein 5B1. (1226 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (570 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
PNKPBifunctional polynucleotide phosphatase/kinase. (521 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (320 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (399 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
LIG1DNA ligase. (921 aa)
LOC103079884Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103081255Histone H2B; Belongs to the histone H2B family. (142 aa)
PARP2Poly [ADP-ribose] polymerase. (591 aa)
RFC3Replication factor C subunit 3. (356 aa)
POLD1DNA polymerase. (1107 aa)
LOC103080427Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081704Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081970Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC103089645Histone H2A; Belongs to the histone H2A family. (128 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (572 aa)
SMUG1Single-strand selective monofunctional uracil DNA glycosylase. (271 aa)
LOC103068403Histone H2B type W-T-like; Belongs to the histone H2B family. (184 aa)
LOC103068676Histone H2B type W-T-like; Belongs to the histone H2B family. (177 aa)
RFC2Replication factor C subunit 2 isoform X1. (352 aa)
VWA5B2Von Willebrand factor A domain-containing protein 5B2. (1255 aa)
LOC103076354Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103079101Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081667Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103082925Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103088169Histone H2B; Belongs to the histone H2B family. (127 aa)
NEIL2Endonuclease 8-like 2. (338 aa)
LOC103076894Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103080928Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103086798Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103074679Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC103076624Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103080666Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103088445Histone H2A; Belongs to the histone H2A family. (117 aa)
LOC103077443Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103085965Histone H2B; Belongs to the histone H2B family. (126 aa)
PARP3Poly [ADP-ribose] polymerase. (536 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
OGG1LOW QUALITY PROTEIN: N-glycosylase/DNA lyase. (318 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (304 aa)
RFC4Replication factor C subunit 4. (364 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (524 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC103074978Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103073911Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103071989Histone H2B; Belongs to the histone H2B family. (126 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (539 aa)
LOC103071706Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103070340Histone H2B; Belongs to the histone H2B family. (126 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
POLD4DNA polymerase delta subunit 4. (107 aa)
LOC103071163Histone H2B; Belongs to the histone H2B family. (126 aa)
POT1Protection of telomeres protein 1. (785 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (312 aa)
POLD3DNA polymerase delta subunit 3. (469 aa)
TINF2TERF1-interacting nuclear factor 2. (453 aa)
RFC1Replication factor C subunit 1. (1245 aa)
LOC103079800Meiotic recombination protein REC114-like. (265 aa)
POLD2DNA polymerase delta subunit 2 isoform X1. (469 aa)
PARGpoly(ADP-ribose) glycohydrolase isoform X1. (975 aa)
LOC103074354Probable DNA-3-methyladenine glycosylase-like. (203 aa)
LOC103079983Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC103089030Uncharacterized protein LOC103089030. (299 aa)
NEIL1Endonuclease 8-like 1. (390 aa)
LIG3DNA ligase. (1013 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
NEIL3Endonuclease 8-like 3. (606 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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