STRINGSTRING
IKBKG IKBKG SPPL2B SPPL2B CLIP3 CLIP3 IKBKE IKBKE TMEM198 TMEM198 RHOA RHOA SOS2 SOS2 USP4 USP4 LOC103068383 LOC103068383 ARHGEF37 ARHGEF37 RBCK1 RBCK1 RNF31 RNF31 NFATC4 NFATC4 NGFRAP1 NGFRAP1 SOS1 SOS1 ARHGEF33 ARHGEF33 FGD1 FGD1 FASLG FASLG SPATA2 SPATA2 RIPK2 RIPK2 MIB2 MIB2 ARHGEF16 ARHGEF16 ARHGEF17 ARHGEF17 SMPD2 SMPD2 TBK1 TBK1 TIAM1 TIAM1 VAV3 VAV3 XIAP XIAP LOC103076248 LOC103076248 RAC1 RAC1 GSAP GSAP BIRC3 BIRC3 BIRC2 BIRC2 UBC UBC LOC103083100 LOC103083100 ARHGEF40 ARHGEF40 WDR31 WDR31 LOC103069796 LOC103069796 TRAF1 TRAF1 KALRN KALRN FAM105A FAM105A SMPD3 SMPD3 ARHGEF38 ARHGEF38 FGD4 FGD4 ARHGEF12 ARHGEF12 LOC103088795 LOC103088795 VAV2 VAV2 TIAM2 TIAM2 PLEKHG5 PLEKHG5 SESTD1 SESTD1 CCDC71L CCDC71L TRIO TRIO PLEKHG2 PLEKHG2 OTUD1 OTUD1 LOC103076438 LOC103076438 RASGRF2 RASGRF2 ARHGEF3 ARHGEF3 OTULIN OTULIN YWHAE YWHAE TAB1 TAB1 MAP3K7 MAP3K7 TNFAIP3 TNFAIP3 MCF2 MCF2 ARHGEF6 ARHGEF6 ARHGEF26 ARHGEF26 BCL2L11 BCL2L11 PSENEN PSENEN CHUK CHUK CASP10 CASP10 MAPKAPK2 MAPKAPK2 MAG MAG CLIP4 CLIP4 LINGO1 LINGO1 ITSN1 ITSN1 BAG4 BAG4 LOC103072471 LOC103072471 RIPK1 RIPK1 OMG OMG ARHGEF9 ARHGEF9 ARHGEF7 ARHGEF7 IKBKB IKBKB SPPL2A SPPL2A LINGO2 LINGO2 ARHGEF39 ARHGEF39 STUB1 STUB1 USP2 USP2 ABR ABR LOC103072950 LOC103072950 SPPL2C SPPL2C GNA13 GNA13 NGF NGF TAB3 TAB3 TRADD TRADD ARHGEF2 ARHGEF2 ARHGEF11 ARHGEF11 MADD MADD LOC103076448 LOC103076448 NAIP NAIP ARHGEF1 ARHGEF1 IRAK1 IRAK1 ADAM17 ADAM17 ARHGEF15 ARHGEF15 CYLD CYLD TAB2 TAB2 ARHGEF10L ARHGEF10L OPTN OPTN TNF TNF LOC103079692 LOC103079692 PSEN1 PSEN1 KXD1 KXD1 TRAF2 TRAF2 TNFRSF10A TNFRSF10A ARHGEF19 ARHGEF19 LOC103080512 LOC103080512 RELA RELA NCSTN NCSTN RTN4R RTN4R ARHGDIA ARHGDIA LOC103083880 LOC103083880 UBB UBB ULK2 ULK2 MYD88 MYD88 LOC103075576 LOC103075576 LOC103079784 LOC103079784 VAV1 VAV1 ARHGEF18 ARHGEF18 GNB2L1 GNB2L1 UBA52 UBA52 UBE2D2 UBE2D2 OTUD7B OTUD7B APH1A APH1A UBE2D3 UBE2D3 LOC103087660 LOC103087660 PSEN2 PSEN2 BIRC7 BIRC7 BAD BAD ARHGEF4 ARHGEF4 UBE2D1 UBE2D1 AATF AATF NFKBIA NFKBIA ULK1 ULK1 NSMAF NSMAF ITGB3BP ITGB3BP RPS27A RPS27A ECT2 ECT2 TNFSF10 TNFSF10 NFKB1 NFKB1 FADD FADD NGFR NGFR LOC103079532 LOC103079532 MCF2L MCF2L SQSTM1 SQSTM1 CASP2 CASP2 SHARPIN SHARPIN LOC103081078 LOC103081078 PRKCI PRKCI NET1 NET1 LOC103088508 LOC103088508 APH1B APH1B TGM3 TGM3 ECT2L ECT2L TGM6 TGM6 RTN4 RTN4 ARHGEF5 ARHGEF5 TAX1BP1 TAX1BP1 FGD3 FGD3 PRDM4 PRDM4 CASP3 CASP3 MCF2L2 MCF2L2 USP21 USP21 LOC103076597 LOC103076597 CASP8 CASP8 FGD2 FGD2 TNFRSF1A TNFRSF1A ARHGEF25 ARHGEF25 CFLAR CFLAR ARHGEF10 ARHGEF10 FAS FAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
SPPL2BLOW QUALITY PROTEIN: signal peptide peptidase like 2B. (450 aa)
CLIP3CAP-Gly domain-containing linker protein 3. (547 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
TMEM198Transmembrane protein 198. (360 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (963 aa)
LOC103068383Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like. (1659 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (675 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1. (510 aa)
RNF31E3 ubiquitin-protein ligase RNF31. (1072 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
NGFRAP1Protein BEX3 isoform X1. (112 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (867 aa)
FGD1FYVE, RhoGEF and PH domain-containing protein 1. (960 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
SPATA2Spermatogenesis-associated protein 2. (520 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
MIB2E3 ubiquitin-protein ligase MIB2 isoform X5. (957 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16 isoform X1. (726 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (2065 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (753 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1592 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (497 aa)
LOC103076248Tumor necrosis factor receptor superfamily member 10A-like. (129 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
GSAPGamma-secretase-activating protein. (854 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
BIRC2LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2. (621 aa)
UBCpolyubiquitin-C. (462 aa)
LOC103083100ubiquitin-60S ribosomal protein L40-like. (116 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40-like isoform X1. (804 aa)
WDR31LOW QUALITY PROTEIN: WD repeat-containing protein 31. (447 aa)
LOC103069796Rho guanine nucleotide exchange factor 40-like; Belongs to the pancreatic ribonuclease family. (1050 aa)
TRAF1TNF receptor-associated factor. (415 aa)
KALRNKalirin isoform X1. (2986 aa)
FAM105AInactive ubiquitin thioesterase FAM105A. (345 aa)
SMPD3Sphingomyelin phosphodiesterase 3 isoform X1. (654 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38 isoform X1. (775 aa)
FGD4FYVE, RhoGEF and PH domain-containing protein 4 isoform X1. (939 aa)
ARHGEF12LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12. (1563 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
TIAM2T-lymphoma invasion and metastasis-inducing protein 2 isoform X1. (1680 aa)
PLEKHG5Pleckstrin homology domain-containing family G member 5 isoform X1. (1074 aa)
SESTD1SEC14 domain and spectrin repeat-containing protein 1. (696 aa)
CCDC71LCoiled-coil domain-containing protein 71L. (235 aa)
TRIOTriple functional domain protein. (3060 aa)
PLEKHG2Pleckstrin homology domain-containing family G member 2. (1398 aa)
OTUD1OTU domain-containing protein 1. (347 aa)
LOC103076438ubiquitin-40S ribosomal protein S27a-like. (155 aa)
RASGRF2Ras-specific guanine nucleotide-releasing factor 2. (1239 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3 isoform X2. (532 aa)
OTULINUbiquitin thioesterase otulin. (352 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
MCF2Proto-oncogene DBL isoform X1. (996 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6. (777 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (870 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
PSENENGamma-secretase subunit PEN-2. (101 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (747 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (456 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
MAGMyelin-associated glycoprotein isoform X1. (626 aa)
CLIP4CAP-Gly domain-containing linker protein 4 isoform X1. (704 aa)
LINGO1Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1. (620 aa)
ITSN1Intersectin-1-like. (616 aa)
BAG4BAG family molecular chaperone regulator 4. (369 aa)
LOC103072471Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (206 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (523 aa)
OMGOligodendrocyte-myelin glycoprotein. (444 aa)
ARHGEF9Rho guanine nucleotide exchange factor 9-like isoform X1. (561 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X2. (803 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
SPPL2ASignal peptide peptidase-like 2A. (504 aa)
LINGO2Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2. (606 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
STUB1E3 ubiquitin-protein ligase CHIP. (303 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (603 aa)
ABRActive breakpoint cluster region-related protein. (964 aa)
LOC103072950Uncharacterized protein LOC103072950. (442 aa)
SPPL2CSignal peptide peptidase-like 2C. (681 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (341 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (987 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11 isoform X1. (1559 aa)
MADDMAP kinase-activating death domain protein isoform X1. (1647 aa)
LOC103076448A-kinase anchor protein 13-like. (184 aa)
NAIPBaculoviral IAP repeat-containing protein 1. (1402 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (913 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 isoform X1. (830 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15 isoform X1. (844 aa)
CYLDLOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (962 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10-like protein. (1282 aa)
OPTNOptineurin. (572 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC103079692Mitogen-activated protein kinase kinase kinase MLT-like isoform X1. (800 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
KXD1kxDL motif-containing protein 1. (176 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
TNFRSF10ATumor necrosis factor receptor superfamily member 10A. (426 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (805 aa)
LOC103080512FYVE, RhoGEF and PH domain-containing protein 2-like. (213 aa)
RELATranscription factor p65 isoform X1. (560 aa)
NCSTNNicastrin isoform X1. (709 aa)
RTN4RReticulon-4 receptor. (831 aa)
ARHGDIARho GDP-dissociation inhibitor 1 isoform X1. (204 aa)
LOC103083880Proline-rich protein 2-like. (275 aa)
UBBpolyubiquitin-C isoform X1. (305 aa)
ULK2Serine/threonine-protein kinase ULK2. (952 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC103075576Tumor necrosis factor receptor superfamily member 10A-like. (266 aa)
LOC103079784Uncharacterized protein. (610 aa)
VAV1Proto-oncogene vav isoform X1. (844 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18. (1121 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
UBE2D2Ubiquitin-conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
OTUD7BOTU domain-containing protein 7B. (843 aa)
APH1AGamma-secretase subunit APH-1A isoform X1. (340 aa)
UBE2D3Ubiquitin-conjugating enzyme E2 D3 isoform X4; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
LOC103087660Ephexin-1-like. (433 aa)
PSEN2Presenilin-2. (407 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (354 aa)
BADBcl2 antagonist of cell death. (168 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (699 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
AATFProtein AATF isoform X1. (566 aa)
NFKBIANF-kappa-B inhibitor alpha. (304 aa)
ULK1Serine/threonine-protein kinase ULK1. (1055 aa)
NSMAFProtein FAN. (900 aa)
ITGB3BPCentromere protein R. (242 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
ECT2Protein ECT2 isoform X1. (933 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (288 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
LOC103079532Tumor necrosis factor receptor superfamily member 26-like. (228 aa)
MCF2LGuanine nucleotide exchange factor DBS. (1060 aa)
SQSTM1Sequestosome-1. (440 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (452 aa)
SHARPINSharpin. (462 aa)
LOC103081078Leucine-rich repeat extensin-like protein 5-like. (449 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
NET1Neuroepithelial cell-transforming gene 1 protein isoform X1. (596 aa)
LOC103088508TNF receptor-associated factor 6-like. (251 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
TGM3Protein-glutamine gamma-glutamyltransferase E. (779 aa)
ECT2LLOW QUALITY PROTEIN: epithelial cell-transforming sequence 2 oncogene-like. (707 aa)
TGM6LOW QUALITY PROTEIN: protein-glutamine gamma-glutamyltransferase 6. (718 aa)
RTN4Reticulon. (1187 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1576 aa)
TAX1BP1Tax1-binding protein 1 homolog isoform X1. (791 aa)
FGD3FYVE, RhoGEF and PH domain-containing protein 3. (742 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
MCF2L2Probable guanine nucleotide exchange factor MCF2L2. (1114 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
LOC103076597ubiquitin-40S ribosomal protein S27a-like. (187 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2. (551 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
ARHGEF25Rho guanine nucleotide exchange factor 25 isoform X1. (618 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (509 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1347 aa)
FASTumor necrosis factor receptor superfamily member 6. (342 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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