STRINGSTRING
IRS1 IRS1 INS INS GRB10 GRB10 TRIB3 TRIB3 MAPK1 MAPK1 KLB KLB IRS2 IRS2 TWF2 TWF2 FGF17 FGF17 MAPK3 MAPK3 FGF7 FGF7 PDPK1 PDPK1 GRB2 GRB2 PIK3R1 PIK3R1 FGF22 FGF22 FGFR3 FGFR3 FGF18 FGF18 FGF4 FGF4 PIK3CA PIK3CA PIK3CB PIK3CB KL KL LOC103081170 LOC103081170 GAB1 GAB1 FGF9 FGF9 FRS2 FRS2 FGFR4 FGFR4 PIK3R4 PIK3R4 FLT3LG FLT3LG PIK3C3 PIK3C3 PDE3B PDE3B PIK3R2 PIK3R2 FGF20 FGF20 FGF10 FGF10 INSR INSR THEM4 THEM4 AKT2 AKT2 SHC1 SHC1 GAB2 GAB2 AKT1 AKT1 FGF16 FGF16 SOS1 SOS1 FGF5 FGF5 FGF3 FGF3 FLT3 FLT3 FGF8 FGF8 FGFR1 FGFR1 PTPN11 PTPN11 FGFR2 FGFR2 FGF2 FGF2 FGF23 FGF23 FGF6 FGF6 FGF1 FGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRS1Insulin receptor substrate 1. (1252 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (349 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1042 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
TWF2Toll-like receptor 9-like isoform X2. (1065 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
FGF22LOW QUALITY PROTEIN: fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (229 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
KLKlotho. (1012 aa)
LOC103081170Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (465 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (296 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
PDE3BPhosphodiesterase. (1121 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (239 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
GAB2GRB2-associated-binding protein 2. (640 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (266 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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