STRINGSTRING
KL KL MAPK3 MAPK3 ATP6V0C ATP6V0C FGF7 FGF7 ATP6V1B1 ATP6V1B1 PDPK1 PDPK1 GRB2 GRB2 PIK3R1 PIK3R1 AKT1 AKT1 ATP6V0D1 ATP6V0D1 ATP6AP1 ATP6AP1 GAB2 GAB2 SHC1 SHC1 LOC103074880 LOC103074880 AKT2 AKT2 ATP6V1C2 ATP6V1C2 ATP6V1G2 ATP6V1G2 CNST CNST PTPN11 PTPN11 FGFR1 FGFR1 IDE IDE ATP6V0E2 ATP6V0E2 FGF8 FGF8 ATP6V1F ATP6V1F FLT3 FLT3 ATP6V1B2 ATP6V1B2 FGF3 FGF3 FGF5 FGF5 THEM4 THEM4 FGF22 FGF22 INSR INSR FGF10 FGF10 NRD1 NRD1 FGF20 FGF20 ATP6V1E2 ATP6V1E2 PIK3R2 PIK3R2 PDE3B PDE3B ATP6V0D2 ATP6V0D2 ATP6V1C1 ATP6V1C1 ATP6V1H ATP6V1H PIK3C3 PIK3C3 FLT3LG FLT3LG PIK3R4 PIK3R4 FGFR4 FGFR4 LIM2 LIM2 FRS2 FRS2 FGF9 FGF9 ATP6V0E1 ATP6V0E1 GAB1 GAB1 CTSD CTSD LOC103081170 LOC103081170 FGF17 FGF17 PIK3CB PIK3CB PIK3CA PIK3CA FGF4 FGF4 FGF18 FGF18 ATP6V0A4 ATP6V0A4 FGFR3 FGFR3 INS INS PTPRF PTPRF IRS1 IRS1 FGF1 FGF1 FGF6 FGF6 FGF23 FGF23 ATP6V0B ATP6V0B ATP6V1E1 ATP6V1E1 FGF2 FGF2 ATP6V1A ATP6V1A FGF16 FGF16 SOS1 SOS1 GRB10 GRB10 PTPN1 PTPN1 ATP6V1D ATP6V1D ATP6V1G3 ATP6V1G3 FGFR2 FGFR2 TRIB3 TRIB3 TCIRG1 TCIRG1 MAPK1 MAPK1 ATP6V0A2 ATP6V0A2 KLB KLB ATP6V1G1 ATP6V1G1 IRS2 IRS2 ATP6AP1L ATP6AP1L ATP6V0A1 ATP6V0A1 TWF2 TWF2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLKlotho. (1012 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ATP6AP1V-type proton ATPase subunit S1. (469 aa)
GAB2GRB2-associated-binding protein 2. (640 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
LOC103074880V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
CNSTConsortin. (722 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
IDEInsulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. (1019 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (266 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (239 aa)
FGF22LOW QUALITY PROTEIN: fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (229 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
NRD1Nardilysin isoform X1. (1232 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
PDE3BPhosphodiesterase. (1121 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (480 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (296 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (218 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
CTSDCathepsin D isoform X1; Belongs to the peptidase A1 family. (412 aa)
LOC103081170Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (465 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X2. (1910 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (233 aa)
ATP6V1E1V-type proton ATPase subunit E 1 isoform X1. (226 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
ATP6V1DV-type proton ATPase subunit D isoform X1. (247 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (349 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1042 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
ATP6AP1LLOW QUALITY PROTEIN: V-type proton ATPase subunit S1-like protein. (340 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
TWF2Toll-like receptor 9-like isoform X2. (1065 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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