STRINGSTRING
FYN FYN PLCG1 PLCG1 FRS2 FRS2 LOC103069787 LOC103069787 BDNF BDNF GRB2 GRB2 NTF4 NTF4 NTRK2 NTRK2 DOCK3 DOCK3 SOS1 SOS1 RAC1 RAC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FYNTyrosine-protein kinase. (537 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
LOC103069787BDNF/NT-3 growth factors receptor-like isoform X1. (553 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (248 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
NTRK2Tyrosine-protein kinase receptor. (366 aa)
DOCK3Dedicator of cytokinesis protein 3; Belongs to the DOCK family. (2025 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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