16 items (Lipotes vexillifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAK2	Tyrosine-protein kinase. (1132 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
	PIK3CG	LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform X1. (217 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (584 aa)
	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
	EPOR	Erythropoietin receptor; Receptor for erythropoietin. (509 aa)
	VAV1	Proto-oncogene vav isoform X1. (844 aa)
	LYN	Tyrosine-protein kinase. (516 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
	CRKL	Crk-like protein. (303 aa)
	IRS2	Insulin receptor substrate 2. (1362 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	EPO	A0A340WQH1	A0A340Y6N9	Crk-like protein.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.517
CRKL	EPOR	A0A340WQH1	A0A340XH95	Crk-like protein.	Erythropoietin receptor; Receptor for erythropoietin.	0.628
CRKL	GRB2	A0A340WQH1	A0A340X5P7	Crk-like protein.	Growth factor receptor-bound protein 2 isoform X1.	0.812
CRKL	IRS2	A0A340WQH1	A0A340WRA4	Crk-like protein.	Insulin receptor substrate 2.	0.455
CRKL	JAK2	A0A340WQH1	A0A340WTZ3	Crk-like protein.	Tyrosine-protein kinase.	0.620
CRKL	LYN	A0A340WQH1	A0A340XV93	Crk-like protein.	Tyrosine-protein kinase.	0.665
CRKL	PIK3CA	A0A340WQH1	A0A340Y0D6	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.761
CRKL	PIK3CB	A0A340WQH1	A0A340XZ14	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.724
CRKL	PIK3CD	A0A340WQH1	A0A340WVB3	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.727
CRKL	PIK3R1	A0A340WQH1	A0A340X6G2	Crk-like protein.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.852
CRKL	RAPGEF1	A0A340WQH1	A0A340WUM9	Crk-like protein.	Rap guanine nucleotide exchange factor 1 isoform X1.	0.998
CRKL	SHC1	A0A340WQH1	A0A340X9E5	Crk-like protein.	SHC-transforming protein 1 isoform X1.	0.752
CRKL	VAV1	A0A340WQH1	A0A340XNP7	Crk-like protein.	Proto-oncogene vav isoform X1.	0.617
EPO	CRKL	A0A340Y6N9	A0A340WQH1	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Crk-like protein.	0.517
EPO	EPOR	A0A340Y6N9	A0A340XH95	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Erythropoietin receptor; Receptor for erythropoietin.	0.996
EPO	GRB2	A0A340Y6N9	A0A340X5P7	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Growth factor receptor-bound protein 2 isoform X1.	0.638
EPO	IRS2	A0A340Y6N9	A0A340WRA4	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Insulin receptor substrate 2.	0.458
EPO	JAK2	A0A340Y6N9	A0A340WTZ3	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.937
EPO	LYN	A0A340Y6N9	A0A340XV93	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.594
EPO	PIK3CA	A0A340Y6N9	A0A340Y0D6	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.512