STRINGSTRING
BMP10 BMP10 IRX1 IRX1 IRX2 IRX2 ITGAV ITGAV ITGB1 ITGB1 ZFYVE16 ZFYVE16 CCNT2 CCNT2 CDK8 CDK8 TGFB2 TGFB2 BAMBI BAMBI MKX MKX PARD3 PARD3 WWTR1 WWTR1 INHBB INHBB IRX4 IRX4 FURIN FURIN CDK9 CDK9 BMP2 BMP2 BMPR2 BMPR2 LOC103076597 LOC103076597 HDAC1 HDAC1 JUNB JUNB DAND5 DAND5 SMAD1 SMAD1 INHBA INHBA F11R F11R TFDP1 TFDP1 CHRDL1 CHRDL1 SMAD2 SMAD2 SMAD7 SMAD7 FOXH1 FOXH1 FKBP1A FKBP1A ATP1B4 ATP1B4 PPM1A PPM1A SKIL SKIL CER1 CER1 SMAD4 SMAD4 RPS27A RPS27A CCNC CCNC NOG NOG NCOR1 NCOR1 PPP1R15A PPP1R15A UBE2D1 UBE2D1 BMPR1B BMPR1B SMAD9 SMAD9 LTBP3 LTBP3 PARP1 PARP1 ACVR2B ACVR2B TRIM33 TRIM33 ITGA8 ITGA8 MEN1 MEN1 UBA52 UBA52 ARHGEF18 ARHGEF18 LOC103079784 LOC103079784 AMH AMH UBB UBB CGN CGN DRAP1 DRAP1 ZFYVE9 ZFYVE9 PCSK4 PCSK4 E2F5 E2F5 TGFBR1 TGFBR1 IRX5 IRX5 SMAD5 SMAD5 RNF111 RNF111 PARD3B PARD3B KXD1 KXD1 LTBP4 LTBP4 TGFB1 TGFB1 LOC103088826 LOC103088826 UBE2M UBE2M MEIS3 MEIS3 SNW1 SNW1 TGFB3 TGFB3 LTBP2 LTBP2 E2F4 E2F4 USP9X USP9X PARD6A PARD6A FST FST IRX3 IRX3 IRX6 IRX6 FAM58A FAM58A BMPR1A BMPR1A TGFBR2 TGFBR2 ITGB3 ITGB3 FBN1 FBN1 TGIF1 TGIF1 ACVR2A ACVR2A ITGB8 ITGB8 SMURF2 SMURF2 LOC103072950 LOC103072950 CBL CBL STUB1 STUB1 GDF2 GDF2 CCNK CCNK ITGB6 ITGB6 ACVR1B ACVR1B CCNT1 CCNT1 STRAP STRAP MAPK3 MAPK3 LOC103076438 LOC103076438 LTBP1 LTBP1 FSTL1 FSTL1 ACVRL1 ACVRL1 NEDD4L NEDD4L CDK19 CDK19 SMURF1 SMURF1 LOC103083100 LOC103083100 ZCCHC4 ZCCHC4 NCOR2 NCOR2 UBC UBC MAPK1 MAPK1 MTMR4 MTMR4 PRKCZ PRKCZ SMAD6 SMAD6 NEDD8 NEDD8 PMEPA1 PMEPA1 ITGB5 ITGB5 SMAD3 SMAD3 ACVR1 ACVR1 CHRDL2 CHRDL2 SKI SKI TGIF2 TGIF2 TFDP2 TFDP2 RBL1 RBL1 ACVR1C ACVR1C RHOA RHOA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP10Bone morphogenetic protein 10. (421 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (578 aa)
IRX2LOW QUALITY PROTEIN: iroquois-class homeodomain protein IRX-2. (466 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1311 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16 isoform X1. (1546 aa)
CCNT2LOW QUALITY PROTEIN: cyclin T2; Belongs to the cyclin family. (669 aa)
CDK8Cyclin-dependent kinase 8 isoform X1; Belongs to the protein kinase superfamily. (464 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
MKXHomeobox protein Mohawk. (652 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1355 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
INHBBInhibin beta B chain. (511 aa)
IRX4Iroquois-class homeodomain protein IRX-4. (520 aa)
FURINFurin isoform X1; Belongs to the peptidase S8 family. (792 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LOC103076597ubiquitin-40S ribosomal protein S27a-like. (187 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (538 aa)
JUNBTranscription factor jun-B. (347 aa)
DAND5LOW QUALITY PROTEIN: DAN domain family member 5. (185 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (430 aa)
F11RJunctional adhesion molecule A. (299 aa)
TFDP1Transcription factor. (410 aa)
CHRDL1Chordin-like protein 1 isoform X1. (459 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
FOXH1Forkhead box protein H1. (360 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
PPM1AProtein phosphatase 1A isoform X1. (456 aa)
SKILSki-like protein isoform X1. (683 aa)
CER1Cerberus. (273 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
CCNCcyclin-C isoform X1; Belongs to the cyclin family. (283 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2431 aa)
PPP1R15ALOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 15A. (569 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X1. (1301 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
TRIM33E3 ubiquitin-protein ligase TRIM33. (1294 aa)
ITGA8Integrin alpha-8; Belongs to the integrin alpha chain family. (1060 aa)
MEN1Menin isoform X1. (631 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18. (1121 aa)
LOC103079784Uncharacterized protein. (610 aa)
AMHMuellerian-inhibiting factor. (558 aa)
UBBpolyubiquitin-C isoform X1. (305 aa)
CGNCingulin. (1194 aa)
DRAP1Dr1-associated corepressor. (205 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1420 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (843 aa)
E2F5Transcription factor E2F5. (346 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
IRX5Iroquois-class homeodomain protein IRX-5 isoform X1. (489 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X1. (994 aa)
PARD3BPartitioning defective 3 homolog B-like. (1046 aa)
KXD1kxDL motif-containing protein 1. (176 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1628 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
LOC103088826Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (143 aa)
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
MEIS3Homeobox protein Meis3 isoform X1. (435 aa)
SNW1SNW domain-containing protein 1 isoform X1. (536 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
LTBP2Latent-transforming growth factor beta-binding protein 2. (1819 aa)
E2F4Transcription factor E2F4. (406 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X-like; Belongs to the peptidase C19 family. (2548 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
FSTFollistatin isoform X1. (344 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (503 aa)
IRX6Iroquois-class homeodomain protein IRX-6. (438 aa)
FAM58ACyclin-related protein FAM58A isoform X1; Belongs to the cyclin family. (202 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
FBN1Fibrillin-1. (2776 aa)
TGIF1Homeobox protein TGIF1 isoform X1. (341 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
LOC103072950Uncharacterized protein LOC103072950. (442 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
STUB1E3 ubiquitin-protein ligase CHIP. (303 aa)
GDF2Growth/differentiation factor 2. (431 aa)
CCNKcyclin-K; Belongs to the cyclin family. (524 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (808 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
CCNT1cyclin-T1; Belongs to the cyclin family. (727 aa)
STRAPSerine-threonine kinase receptor-associated protein. (350 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
LOC103076438ubiquitin-40S ribosomal protein S27a-like. (155 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1713 aa)
FSTL1Follistatin-related protein 1. (307 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
NEDD4LE3 ubiquitin-protein ligase. (854 aa)
CDK19Cyclin-dependent kinase 19 isoform X1. (502 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (720 aa)
LOC103083100ubiquitin-60S ribosomal protein L40-like. (116 aa)
ZCCHC4Zinc finger CCHC domain-containing protein 4. (513 aa)
NCOR2LOW QUALITY PROTEIN: nuclear receptor corepressor 2. (2507 aa)
UBCpolyubiquitin-C. (462 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1210 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
NEDD8NEDD8. (81 aa)
PMEPA1Transmembrane prostate androgen-induced protein. (289 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CHRDL2Chordin-like protein 2 isoform X1. (452 aa)
SKISki oncogene. (731 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
TFDP2Transcription factor. (447 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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