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GRB2 | Growth factor receptor-bound protein 2 isoform X1. (217 aa) | ||||
CRKL | Crk-like protein. (303 aa) | ||||
IRS2 | Insulin receptor substrate 2. (1362 aa) | ||||
JAK2 | Tyrosine-protein kinase. (1132 aa) | ||||
RAPGEF1 | Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa) | ||||
SHC1 | SHC-transforming protein 1 isoform X1. (584 aa) | ||||
EPOR | Erythropoietin receptor; Receptor for erythropoietin. (509 aa) | ||||
VAV1 | Proto-oncogene vav isoform X1. (844 aa) | ||||
LYN | Tyrosine-protein kinase. (516 aa) | ||||
EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa) |