STRINGSTRING
GRB2 GRB2 CRKL CRKL IRS2 IRS2 JAK2 JAK2 RAPGEF1 RAPGEF1 SHC1 SHC1 EPOR EPOR VAV1 VAV1 LYN LYN EPO EPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
CRKLCrk-like protein. (303 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
VAV1Proto-oncogene vav isoform X1. (844 aa)
LYNTyrosine-protein kinase. (516 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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