STRINGSTRING
SOS2 SOS2 SHC3 SHC3 KRAS KRAS SRC SRC SOS1 SOS1 FOXO3 FOXO3 EIF4EBP1 EIF4EBP1 BCL2L1 BCL2L1 STAT3 STAT3 IL6 IL6 GSK3B GSK3B MAP2K1 MAP2K1 PDGFRB PDGFRB MET MET PRKCB PRKCB MAPK1 MAPK1 RPS6KB1 RPS6KB1 NF1 NF1 PDGFD PDGFD KDR KDR ARAF ARAF PIK3R3 PIK3R3 RPS6KB2 RPS6KB2 JAK2 JAK2 PIK3CD PIK3CD PLCG2 PLCG2 IGF1 IGF1 MAPK3 MAPK3 TGFA TGFA PRKCA PRKCA SHC4 SHC4 PDGFRA PDGFRA PDGFB PDGFB GRB2 GRB2 PIK3R1 PIK3R1 AKT1 AKT1 IL6R IL6R SHC1 SHC1 AKT2 AKT2 VEGFA VEGFA AXL AXL PRKCG PRKCG SHC2 SHC2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 JAK1 JAK1 AKT3 AKT3 NRG2 NRG2 BAX BAX RAF1 RAF1 EGFR EGFR PDGFC PDGFC BAD BAD MTOR MTOR NRAS NRAS PLCG1 PLCG1 BCL2 BCL2 EIF4E2 EIF4E2 ERBB2 ERBB2 EGF EGF EIF4E1B EIF4E1B EIF4E EIF4E GAB1 GAB1 GAS6 GAS6 PIK3CB PIK3CB PIK3CA PIK3CA NRG1 NRG1 PDGFA PDGFA FGFR3 FGFR3 HRAS HRAS BRAF BRAF HGF HGF ERBB3 ERBB3 IGF1R IGF1R PTEN PTEN FGF2 FGF2 FGFR2 FGFR2 RPS6 RPS6 BCL2L11 BCL2L11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
KRASGTPase KRas. (188 aa)
SRCTyrosine-protein kinase. (548 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
FOXO3Forkhead box protein O3. (672 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NF1Neurofibromin isoform X1. (2841 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
TGFAProtransforming growth factor alpha. (145 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL6RInterleukin-6 receptor subunit alpha. (499 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (887 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (757 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
BADBcl2 antagonist of cell death. (168 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (230 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
GAS6Growth arrest-specific protein 6. (540 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
NRG1Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (641 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
HRASGTPase HRas isoform X1. (189 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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