STRINGSTRING
MAPK8 MAPK8 SOS2 SOS2 SHC3 SHC3 CAMK2B CAMK2B KRAS KRAS SRC SRC STAT5B STAT5B SOS1 SOS1 EIF4EBP1 EIF4EBP1 STAT5A STAT5A GSK3B GSK3B MAP2K1 MAP2K1 CAMK2A CAMK2A PRKCB PRKCB MAPK1 MAPK1 ABL2 ABL2 RPS6KB1 RPS6KB1 CRKL CRKL ARAF ARAF PIK3R3 PIK3R3 RPS6KB2 RPS6KB2 ELK1 ELK1 PIK3CD PIK3CD ABL1 ABL1 PLCG2 PLCG2 PAK7 PAK7 MAPK3 MAPK3 CRK CRK CAMK2D CAMK2D TGFA TGFA PRKCA PRKCA SHC4 SHC4 CBL CBL GRB2 GRB2 NCK2 NCK2 PIK3R1 PIK3R1 AKT1 AKT1 MAP2K4 MAP2K4 MYC MYC SHC1 SHC1 NRG3 NRG3 AKT2 AKT2 NCK1 NCK1 MAP2K7 MAP2K7 PRKCG PRKCG HBEGF HBEGF SHC2 SHC2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 PAK6 PAK6 JUN JUN AKT3 AKT3 NRG2 NRG2 PAK1 PAK1 AREG AREG EREG EREG RAF1 RAF1 CBLB CBLB EGFR EGFR BAD BAD MTOR MTOR BTC BTC NRAS NRAS PAK4 PAK4 PLCG1 PLCG1 ERBB2 ERBB2 EGF EGF MAPK9 MAPK9 MAPK10 MAPK10 PAK2 PAK2 GAB1 GAB1 PIK3CB PIK3CB PAK3 PAK3 PTK2 PTK2 PIK3CA PIK3CA NRG1 NRG1 HRAS HRAS BRAF BRAF CAMK2G CAMK2G ERBB3 ERBB3 CDKN1A CDKN1A ERBB4 ERBB4 CDKN1B CDKN1B NRG4 NRG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
KRASGTPase KRas. (188 aa)
SRCTyrosine-protein kinase. (548 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
ABL2Tyrosine-protein kinase. (1067 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CRKLCrk-like protein. (303 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (444 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
PAK7Non-specific serine/threonine protein kinase. (719 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
CAMK2DLOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta. (536 aa)
TGFAProtransforming growth factor alpha. (145 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
NCK2Cytoplasmic protein. (376 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (613 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
NCK1Cytoplasmic protein. (377 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
PAK6Non-specific serine/threonine protein kinase. (675 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (757 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
AREGAmphiregulin isoform X1. (254 aa)
EREGProepiregulin. (163 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (983 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BADBcl2 antagonist of cell death. (168 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
BTCProbetacellulin. (178 aa)
NRASGTPase NRas. (189 aa)
PAK4Non-specific serine/threonine protein kinase. (591 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (579 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
NRG1Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (641 aa)
HRASGTPase HRas isoform X1. (189 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (672 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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