STRINGSTRING
AGTR1 AGTR1 RHOA RHOA SOS2 SOS2 SHC3 SHC3 KRAS KRAS GRM3 GRM3 ARF6 ARF6 SYK SYK ADCY2 ADCY2 DGKD DGKD SOS1 SOS1 GRM8 GRM8 DNM3 DNM3 ADCY1 ADCY1 ADCY4 ADCY4 GNAS GNAS ADCY8 ADCY8 MAP2K1 MAP2K1 PDGFRB PDGFRB AGT AGT MAPK1 MAPK1 LOC103079834 LOC103079834 CYTH3 CYTH3 KITLG KITLG ADCY5 ADCY5 LOC103085385 LOC103085385 PLCB4 PLCB4 AVPR1A AVPR1A LOC103069618 LOC103069618 LPAR1 LPAR1 PDGFD PDGFD FYN FYN PLCB1 PLCB1 GRM1 GRM1 PIK3R3 PIK3R3 ADCY6 ADCY6 DGKG DGKG DGKK DGKK PIK3CD PIK3CD PLA2G4A PLA2G4A LOC103089330 LOC103089330 LOC103068417 LOC103068417 CXCR2 CXCR2 CYTH4 CYTH4 PLCG2 PLCG2 GRM2 GRM2 MAPK3 MAPK3 SPHK1 SPHK1 AGPAT3 AGPAT3 GRM6 GRM6 RALGDS RALGDS ADCY9 ADCY9 PRKCA PRKCA TSC1 TSC1 ADCY3 ADCY3 SHC4 SHC4 PIK3CG PIK3CG F2 F2 PDGFRA PDGFRA TSC2 TSC2 LOC103075361 LOC103075361 PDGFB PDGFB AVPR2 AVPR2 GRB2 GRB2 GNA13 GNA13 PIK3R1 PIK3R1 AKT1 AKT1 LOC103084596 LOC103084596 PIK3R6 PIK3R6 GAB2 GAB2 PLD2 PLD2 LOC103075075 LOC103075075 ARF1 ARF1 SHC1 SHC1 DGKZ DGKZ KIT KIT AKT2 AKT2 LOC103080863 LOC103080863 LOC103089703 LOC103089703 LPAR3 LPAR3 AGPAT4 AGPAT4 PIK3R5 PIK3R5 PTGFR PTGFR PLA2G4F PLA2G4F PIP5K1A PIP5K1A PIP5K1C PIP5K1C INSR INSR DNM2 DNM2 RAPGEF4 RAPGEF4 LPAR2 LPAR2 PLA2G4B PLA2G4B PLCB2 PLCB2 LOC103090583 LOC103090583 AGPAT1 AGPAT1 SHC2 SHC2 MAP2K2 MAP2K2 GRM5 GRM5 ADCY7 ADCY7 PLCB3 PLCB3 PIK3R2 PIK3R2 PLA2G4D PLA2G4D RRAS2 RRAS2 FCER1A FCER1A PPAP2C PPAP2C PLA2G4E PLA2G4E AKT3 AKT3 GRM4 GRM4 CYTH2 CYTH2 CYTH1 CYTH1 RAF1 RAF1 F2R F2R EGFR EGFR LOC103080976 LOC103080976 PDGFC PDGFC MS4A2 MS4A2 MTOR MTOR NRAS NRAS RRAS RRAS PPAP2B PPAP2B PLCG1 PLCG1 RALA RALA DGKB DGKB EGF EGF SPHK2 SPHK2 AVP AVP DGKE DGKE RAPGEF3 RAPGEF3 GAB1 GAB1 PTK2B PTK2B LPAR4 LPAR4 MRAS MRAS PIK3CB PIK3CB LPAR6 LPAR6 PIP5K1B PIP5K1B PLD1 PLD1 PIK3CA PIK3CA PDGFA PDGFA GNA12 GNA12 DGKQ DGKQ HRAS HRAS INS INS DGKI DGKI DGKA DGKA FCER1G FCER1G IL8 IL8 RALB RALB AGPAT5 AGPAT5 PTPN11 PTPN11 DGKH DGKH LPAR5 LPAR5 RHEB RHEB AVPR1B AVPR1B DNM1 DNM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
KRASGTPase KRas. (188 aa)
GRM3Metabotropic glutamate receptor 3 isoform X1. (879 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
DGKDDiacylglycerol kinase. (1222 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
GRM8Metabotropic glutamate receptor 8. (178 aa)
DNM3Dynamin-3 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (863 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103079834Metabotropic glutamate receptor 7-like. (282 aa)
CYTH3Cytohesin-3. (351 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
LOC103069618GTP-binding protein Rheb-like. (184 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
FYNTyrosine-protein kinase. (537 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1194 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
DGKGDiacylglycerol kinase. (791 aa)
DGKKDiacylglycerol kinase. (1229 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
PLA2G4APhospholipase A2. (749 aa)
LOC103089330LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta-like. (268 aa)
LOC103068417c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (334 aa)
CXCR2c-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (328 aa)
CYTH4Cytohesin-4. (407 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
GRM2Metabotropic glutamate receptor 2. (872 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
SPHK1Sphingosine kinase 1. (484 aa)
AGPAT31-acyl-sn-glycerol-3-phosphate acyltransferase gamma. (376 aa)
GRM6Metabotropic glutamate receptor 6. (931 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (842 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
TSC1Hamartin isoform X1. (1170 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
TSC2Tuberin. (1793 aa)
LOC103075361Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC103084596Metabotropic glutamate receptor 8-like. (215 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
GAB2GRB2-associated-binding protein 2. (640 aa)
PLD2Phospholipase. (933 aa)
LOC103075075Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
ARF1ADP-ribosylation factor 1 isoform X1; Belongs to the small GTPase superfamily. Arf family. (204 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
DGKZDiacylglycerol kinase. (1120 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
LOC1030808631-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (485 aa)
LOC103089703ADP-ribosylation factor 2-like isoform X1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (355 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta. (378 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
PTGFRProstaglandin F2-alpha receptor isoform X1. (362 aa)
PLA2G4FPhospholipase A2. (849 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (828 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
PLA2G4BPhospholipase A2. (780 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
LOC103090583Metabotropic glutamate receptor 8-like. (591 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1204 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
PLA2G4DPhospholipase A2. (818 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (127 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha. (262 aa)
PPAP2CLOW QUALITY PROTEIN: lipid phosphate phosphohydrolase 2. (550 aa)
PLA2G4EPhospholipase A2. (883 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GRM4Metabotropic glutamate receptor 4 isoform X1. (957 aa)
CYTH2Cytohesin-2 isoform X1. (421 aa)
CYTH1Cytohesin-1. (338 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (428 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
LOC103080976Metabotropic glutamate receptor 7-like isoform X1. (714 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta. (243 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
RRASRas-related protein R-Ras. (218 aa)
PPAP2BLipid phosphate phosphohydrolase 3. (312 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RALARas-related protein Ral-A. (206 aa)
DGKBDiacylglycerol kinase beta. (597 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
DGKEDiacylglycerol kinase. (602 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LPAR4Lysophosphatidic acid receptor 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (408 aa)
MRASRas-related protein M-Ras isoform X1. (208 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (540 aa)
PLD1Phospholipase. (1074 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (480 aa)
DGKQDiacylglycerol kinase. (937 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
DGKIDiacylglycerol kinase. (1078 aa)
DGKADiacylglycerol kinase. (734 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (87 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
RALBRas-related protein Ral-B. (206 aa)
AGPAT51-acyl-sn-glycerol-3-phosphate acyltransferase epsilon. (365 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
DGKHDiacylglycerol kinase. (1216 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (367 aa)
RHEBGTP-binding protein Rheb. (184 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
DNM1Dynamin-1 isoform X3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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