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ADIPOQ ADIPOQ KRAS KRAS ADCY2 ADCY2 FOXO3 FOXO3 SESN1 SESN1 EIF4EBP1 EIF4EBP1 PRKAG3 PRKAG3 PRKAB2 PRKAB2 LOC103079897 LOC103079897 ADCY1 ADCY1 ADCY4 ADCY4 LOC103082901 LOC103082901 ADCY8 ADCY8 PPARGC1A PPARGC1A CAMKK2 CAMKK2 ADCY5 ADCY5 RPS6KB1 RPS6KB1 IRS2 IRS2 PRKAG1 PRKAG1 LOC103069618 LOC103069618 PIK3R3 PIK3R3 ADCY6 ADCY6 RPS6KB2 RPS6KB2 ATF2 ATF2 CAMK4 CAMK4 PIK3CD PIK3CD LOC103076886 LOC103076886 APPL1 APPL1 SESN3 SESN3 LOC103082019 LOC103082019 ATF4 ATF4 ATG101 ATG101 IGF1 IGF1 ADCY9 ADCY9 TSC1 TSC1 ADCY3 ADCY3 ATG13 ATG13 TSC2 TSC2 LOC103069928 LOC103069928 CREB3 CREB3 PIK3R1 PIK3R1 AKT1 AKT1 LOC103090756 LOC103090756 CREB3L1 CREB3L1 ADIPOR1 ADIPOR1 AKT2 AKT2 EHMT1 EHMT1 SIRT1 SIRT1 TP53 TP53 PRKACB PRKACB CREB3L4 CREB3L4 INSR INSR ATF6B ATF6B EHMT2 EHMT2 ADCY7 ADCY7 RELA RELA PIK3R2 PIK3R2 CREB3L3 CREB3L3 AKT3 AKT3 STK11 STK11 SOD2 SOD2 SESN2 SESN2 BAX BAX PPARG PPARG IRS4 IRS4 RB1CC1 RB1CC1 MTOR MTOR NRAS NRAS RPTOR RPTOR PRKAA2 PRKAA2 PRKAB1 PRKAB1 EIF4E2 EIF4E2 ULK1 ULK1 EIF4E1B EIF4E1B AKT1S1 AKT1S1 EIF4E EIF4E NFKB1 NFKB1 ATG5 ATG5 CREB5 CREB5 KL KL PIK3CB PIK3CB PIK3CA PIK3CA CREB3L2 CREB3L2 CAT CAT HRAS HRAS INS INS IRS1 IRS1 PRKACA PRKACA PRKAG2 PRKAG2 ADIPOR2 ADIPOR2 IGF1R IGF1R CREB1 CREB1 PRKAA1 PRKAA1 RHEB RHEB LOC103077612 LOC103077612 FOXO1 FOXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
KRASGTPase KRas. (188 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
FOXO3Forkhead box protein O3. (672 aa)
SESN1Sestrin-1 isoform X1. (551 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X3. (482 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
LOC103079897Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (198 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
LOC103082901Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (707 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (796 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (580 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X2. (336 aa)
LOC103069618GTP-binding protein Rheb-like. (184 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
LOC103076886Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (497 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
SESN3Sestrin-3 isoform X1. (492 aa)
LOC103082019Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (574 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
ATG101Autophagy-related protein 101. (218 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
TSC1Hamartin isoform X1. (1170 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (551 aa)
TSC2Tuberin. (1793 aa)
LOC103069928Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (711 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (376 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC103090756Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (479 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
EHMT1Histone-lysine N-methyltransferase EHMT1. (1265 aa)
SIRT1LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1. (695 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (426 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (709 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2-like isoform X1. (1209 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2. (458 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (438 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
SESN2Sestrin-2 isoform X1. (480 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
RB1CC1RB1-inducible coiled-coil protein 1. (1589 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
ULK1Serine/threonine-protein kinase ULK1. (1055 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (230 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
KLKlotho. (1012 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
RHEBGTP-binding protein Rheb. (184 aa)
LOC103077612Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (198 aa)
FOXO1Forkhead box protein O1. (655 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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