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KRAS KRAS SOD1 SOD1 ADCY2 ADCY2 FOXO3 FOXO3 PRKAG3 PRKAG3 PRKAB2 PRKAB2 LOC103079897 LOC103079897 ADCY1 ADCY1 ADCY4 ADCY4 LOC103082901 LOC103082901 ADCY8 ADCY8 ADCY5 ADCY5 RPS6KB1 RPS6KB1 IRS2 IRS2 PRKAG1 PRKAG1 HDAC2 HDAC2 PIK3R3 PIK3R3 ADCY6 ADCY6 RPS6KB2 RPS6KB2 PIK3CD PIK3CD LOC103076886 LOC103076886 LOC103082019 LOC103082019 IGF1 IGF1 FOXA2 FOXA2 ADCY9 ADCY9 ADCY3 ADCY3 LOC103069928 LOC103069928 PIK3R1 PIK3R1 AKT1 AKT1 LOC103090756 LOC103090756 LOC103069935 LOC103069935 AKT2 AKT2 SIRT1 SIRT1 HSPA1L HSPA1L PRKACB PRKACB INSR INSR LOC103073518 LOC103073518 ADCY7 ADCY7 PIK3R2 PIK3R2 AKT3 AKT3 LOC103071041 LOC103071041 SOD2 SOD2 IRS4 IRS4 MTOR MTOR NRAS NRAS RPTOR RPTOR PRKAA2 PRKAA2 PRKAB1 PRKAB1 CLPB CLPB AKT1S1 AKT1S1 ATG5 ATG5 PIK3CB PIK3CB CRYAB CRYAB PIK3CA PIK3CA CAT CAT HRAS HRAS INS INS IRS1 IRS1 PRKACA PRKACA HDAC1 HDAC1 PRKAG2 PRKAG2 IGF1R IGF1R LOC103074840 LOC103074840 PRKAA1 PRKAA1 LOC103077612 LOC103077612 LOC103070273 LOC103070273 FOXO1 FOXO1 HSPA8 HSPA8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASGTPase KRas. (188 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
FOXO3Forkhead box protein O3. (672 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X3. (482 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
LOC103079897Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (198 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
LOC103082901Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (707 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X2. (336 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
LOC103076886Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (497 aa)
LOC103082019Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (574 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
FOXA2Hepatocyte nuclear factor 3-beta. (466 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
LOC103069928Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (711 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC103090756Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (479 aa)
LOC103069935Chaperone protein ClpB2, chloroplastic-like; Belongs to the ClpA/ClpB family. (701 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
SIRT1LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1. (695 aa)
HSPA1LLOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (634 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
LOC103073518Heat shock 70 kDa protein 1B-like; Belongs to the heat shock protein 70 family. (641 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC103071041Heat shock-related 70 kDa protein 2-like; Belongs to the heat shock protein 70 family. (638 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
CLPBCaseinolytic peptidase B protein homolog isoform X1. (707 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (538 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LOC103074840Heat shock cognate 71 kDa protein-like; Belongs to the heat shock protein 70 family. (634 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
LOC103077612Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (198 aa)
LOC103070273Chaperone protein ClpB2, chloroplastic-like; Belongs to the ClpA/ClpB family. (854 aa)
FOXO1Forkhead box protein O1. (655 aa)
HSPA8LOW QUALITY PROTEIN: heat shock 70kDa protein 8; Belongs to the heat shock protein 70 family. (650 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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