STRINGSTRING
EDN2 EDN2 AGTR1 AGTR1 RHOA RHOA MYLK2 MYLK2 PRKCD PRKCD MYH9 MYH9 ADCY2 ADCY2 RAMP3 RAMP3 CALML4 CALML4 EDN1 EDN1 PPP1CC PPP1CC KCNMB1 KCNMB1 ITPR2 ITPR2 ADCY1 ADCY1 EDN3 EDN3 LOC103076060 LOC103076060 CACNA1D CACNA1D MYL9 MYL9 ADCY4 ADCY4 KCNU1 KCNU1 GNAS GNAS CALCB CALCB ADCY8 ADCY8 MAP2K1 MAP2K1 AGT AGT LOC103079728 LOC103079728 PRKCB PRKCB PPP1R12A PPP1R12A MAPK1 MAPK1 LOC103082455 LOC103082455 CALML6 CALML6 ADCY5 ADCY5 ADORA2A ADORA2A LOC103085385 LOC103085385 PLCB4 PLCB4 LOC103069617 LOC103069617 AVPR1A AVPR1A MYLK4 MYLK4 MYLK MYLK RAMP2 RAMP2 PPP1CA PPP1CA PLCB1 PLCB1 ARAF ARAF MYLK3 MYLK3 ADCY6 ADCY6 RAMP1 RAMP1 ARHGEF12 ARHGEF12 CACNA1F CACNA1F PLA2G4A PLA2G4A PLA2G3 PLA2G3 KCNMB2 KCNMB2 PLA2G6 PLA2G6 MAPK3 MAPK3 PLA2G12B PLA2G12B ADCY9 ADCY9 PRKCA PRKCA ADCY3 ADCY3 ITPR1 ITPR1 CACNA1S CACNA1S NPR2 NPR2 PPP1R12B PPP1R12B GNA13 GNA13 GUCY1A2 GUCY1A2 ARHGEF11 ARHGEF11 PTGIR PTGIR ARHGEF1 ARHGEF1 LOC103086084 LOC103086084 ROCK2 ROCK2 PLA2G2D PLA2G2D PLA2G5 PLA2G5 ACTG2 ACTG2 PRKACB PRKACB GNAQ GNAQ PLA2G4F PLA2G4F MYH10 MYH10 LOC103090842 LOC103090842 GNA11 GNA11 NPR1 NPR1 CALM3 CALM3 PRKCG PRKCG PRKCE PRKCE PLA2G2E PLA2G2E PLA2G4B PLA2G4B PLCB2 PLCB2 PLA2G2F PLA2G2F MAP2K2 MAP2K2 ADCY7 ADCY7 LOC103075302 LOC103075302 PLCB3 PLCB3 PLA2G4D PLA2G4D PLA2G4E PLA2G4E ADORA2B ADORA2B NPPC NPPC GUCY1B3 GUCY1B3 ITPR3 ITPR3 PLA2G12A PLA2G12A RAF1 RAF1 LOC103079421 LOC103079421 NPPA NPPA NPPB NPPB AVP AVP MYH14 MYH14 KCNMB4 KCNMB4 LOC103085729 LOC103085729 PRKCQ PRKCQ LOC103086011 LOC103086011 ADRA1B ADRA1B PLA2G10 PLA2G10 MYL6 MYL6 GNA12 GNA12 LOC103074541 LOC103074541 CALML5 CALML5 MYL6B MYL6B MYH11 MYH11 ADRA1A ADRA1A CALD1 CALD1 BRAF BRAF PRKACA PRKACA CACNA1C CACNA1C LOC103072349 LOC103072349 PPP1R12C PPP1R12C PRKG1 PRKG1 PPP1R14A PPP1R14A ADM ADM MRVI1 MRVI1 PLA2G2C PLA2G2C ACTA2 ACTA2 CALCRL CALCRL AVPR1B AVPR1B PPP1CB PPP1CB CALM1 CALM1 PRKCH PRKCH ADRA1D ADRA1D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDN2Endothelin-2. (180 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (597 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
MYH9Myosin-9 isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
RAMP3Receptor activity-modifying protein 3. (147 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
EDN1Endothelin-1. (202 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (195 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
EDN3Endothelin-3. (211 aa)
LOC103076060LOW QUALITY PROTEIN: calcitonin receptor-stimulating peptide 2-like. (202 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
MYL9Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
KCNU1Potassium channel subfamily U member 1. (1126 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
CALCBCalcitonin gene-related peptide 2 isoform X1. (138 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
LOC103079728Phospholipase A(2). (147 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (943 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CALML6Calmodulin-like protein 6. (190 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
LOC103069617Calcitonin receptor-stimulating peptide 1-like. (127 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (377 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (1962 aa)
RAMP2Receptor activity-modifying protein 2. (177 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
RAMP1Receptor activity-modifying protein 1 isoform X2. (148 aa)
ARHGEF12LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12. (1563 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1976 aa)
PLA2G4APhospholipase A2. (749 aa)
PLA2G3Group 3 secretory phospholipase A2. (516 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2. (805 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
PLA2G12BGroup XIIB secretory phospholipase A2-like protein isoform X1. (195 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
NPR2Guanylate cyclase. (1052 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (890 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (658 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11 isoform X1. (1559 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (913 aa)
LOC103086084LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like. (375 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
PLA2G2DPhospholipase A(2). (161 aa)
PLA2G5Phospholipase A(2). (138 aa)
ACTG2Actin, gamma-enteric smooth muscle isoform X1. (376 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PLA2G4FPhospholipase A2. (849 aa)
MYH10Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
LOC103090842Calcitonin receptor-stimulating peptide 3-like. (125 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
NPR1Guanylate cyclase. (1058 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. (493 aa)
PLA2G2EPhospholipase A(2). (142 aa)
PLA2G4BPhospholipase A2. (780 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
PLA2G2FPhospholipase A(2). (206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
LOC103075302Guanylate cyclase soluble subunit alpha-1-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PLA2G4DPhospholipase A2. (818 aa)
PLA2G4EPhospholipase A2. (883 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
NPPCC-type natriuretic peptide. (126 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (551 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PLA2G12AGroup XIIA secretory phospholipase A2. (188 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC103079421Group XIIA secretory phospholipase A2-like. (115 aa)
NPPANatriuretic peptides A. (152 aa)
NPPBNatriuretic peptides B. (132 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
MYH14Myosin-14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1855 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
LOC103085729Cytochrome P450 4A11-like; Belongs to the cytochrome P450 family. (510 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LOC103086011Cytochrome P450 4A11-like; Belongs to the cytochrome P450 family. (510 aa)
ADRA1Balpha-1B adrenergic receptor. (519 aa)
PLA2G10Phospholipase A(2). (159 aa)
MYL6Myosin light polypeptide 6 isoform X1. (151 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (480 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
CALML5Calmodulin-like protein 5. (140 aa)
MYL6BMyosin light chain 6B. (213 aa)
MYH11Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
ADRA1Aalpha-1A adrenergic receptor. (467 aa)
CALD1Non-muscle caldesmon isoform X1. (554 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2112 aa)
LOC103072349Calcium-activated potassium channel subunit alpha-1-like. (1073 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (784 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PPP1R14AProtein phosphatase 1 regulatory subunit 14A. (147 aa)
ADMADM. (188 aa)
MRVI1Protein MRVI1 isoform X1. (911 aa)
PLA2G2CLOW QUALITY PROTEIN: phospholipase A2, group IIC. (217 aa)
ACTA2Actin, aortic smooth muscle isoform X1. (377 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
PRKCHProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
ADRA1Dalpha-1D adrenergic receptor. (569 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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