STRINGSTRING
CSNK1A1 CSNK1A1 IHH IHH GAS1 GAS1 GSK3B GSK3B CSNK1G1 CSNK1G1 PTCH1 PTCH1 SMURF1 SMURF1 CUL3 CUL3 LRP2 LRP2 PTCH2 PTCH2 DHH DHH ADRBK1 ADRBK1 CSNK1E CSNK1E CSNK1G3 CSNK1G3 MGRN1 MGRN1 SPOPL SPOPL ARRB1 ARRB1 SMURF2 SMURF2 SHH SHH GPR161 GPR161 BOC BOC ARRB2 ARRB2 PRKACB PRKACB MEGF8 MEGF8 CSNK1G2 CSNK1G2 EVC EVC ADRBK2 ADRBK2 CDON CDON KIF3A KIF3A HHIP HHIP EVC2 EVC2 CSNK1D CSNK1D BCL2 BCL2 SPOP SPOP LOC103072895 LOC103072895 FBXW11 FBXW11 CCND1 CCND1 GLI1 GLI1 PRKACA PRKACA GLI3 GLI3 CCND2 CCND2 SUFU SUFU CUL1 CUL1 KIF7 KIF7 GLI2 GLI2 SMO SMO BTRC BTRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSNK1A1Casein kinase I isoform alpha isoform X1; Belongs to the protein kinase superfamily. (365 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
GAS1Growth arrest-specific protein 1. (260 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CSNK1G1Casein kinase I isoform gamma-1 isoform X1; Belongs to the protein kinase superfamily. (473 aa)
PTCH1Protein patched homolog 1 isoform X1. (1448 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (720 aa)
CUL3Cullin-3; Belongs to the cullin family. (653 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4672 aa)
PTCH2Protein patched homolog 2. (1211 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
ADRBK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (692 aa)
CSNK1ECasein kinase I isoform epsilon isoform X2; Belongs to the protein kinase superfamily. (416 aa)
CSNK1G3Casein kinase I isoform gamma-3 isoform X1; Belongs to the protein kinase superfamily. (455 aa)
MGRN1E3 ubiquitin-protein ligase MGRN1 isoform X1. (571 aa)
SPOPLSpeckle-type POZ protein-like isoform X1. (392 aa)
ARRB1Beta-arrestin-1. (418 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
GPR161G-protein coupled receptor 161 isoform X1; Belongs to the G-protein coupled receptor 1 family. (528 aa)
BOCBrother of CDO. (1116 aa)
ARRB2Beta-arrestin-2 isoform X1. (421 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2778 aa)
CSNK1G2Casein kinase I isoform gamma-2 isoform X1; Belongs to the protein kinase superfamily. (419 aa)
EVCEllis-van Creveld syndrome protein. (994 aa)
ADRBK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1250 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
HHIPHedgehog-interacting protein-like isoform X1. (700 aa)
EVC2Limbin. (1300 aa)
CSNK1DCasein kinase I isoform delta isoform X1; Belongs to the protein kinase superfamily. (428 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
SPOPSpeckle-type POZ protein. (374 aa)
LOC103072895Uncharacterized protein C16orf52 homolog. (167 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (542 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
GLI3Transcriptional activator GLI3. (1590 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
CUL1Cullin-1 isoform X1; Belongs to the cullin family. (776 aa)
KIF7LOW QUALITY PROTEIN: kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1342 aa)
GLI2Zinc finger protein GLI2. (1553 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
BTRCF-box/WD repeat-containing protein 1A. (579 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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