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BMP4 BMP4 RHOA RHOA ID4 ID4 ACVR1C ACVR1C RBL1 RBL1 LOC103090703 LOC103090703 TGIF2 TGIF2 ID1 ID1 ACVR1 ACVR1 SMAD3 SMAD3 NEO1 NEO1 BMP7 BMP7 PPP2CB PPP2CB GDF5 GDF5 RGMA RGMA SMAD6 SMAD6 MAPK1 MAPK1 LOC103082455 LOC103082455 SMURF1 SMURF1 FMOD FMOD RPS6KB1 RPS6KB1 DCN DCN LOC103079743 LOC103079743 RPS6KB2 RPS6KB2 LTBP1 LTBP1 PITX2 PITX2 CREBBP CREBBP LOC103079191 LOC103079191 RBX1 RBX1 EP300 EP300 MAPK3 MAPK3 GDF6 GDF6 LEFTY2 LEFTY2 LOC103089261 LOC103089261 BMP8B BMP8B SMURF2 SMURF2 LOC103073398 LOC103073398 ACVR2A ACVR2A NODAL NODAL CDKN2B CDKN2B MYC MYC TGIF1 TGIF1 FBN1 FBN1 LOC103082213 LOC103082213 TGFBR2 TGFBR2 BMPR1A BMPR1A ID3 ID3 ID2 ID2 HFE2 HFE2 FST FST E2F4 E2F4 TGFB3 TGFB3 TNF TNF TGFB1 TGFB1 NBL1 NBL1 SMAD5 SMAD5 THBS1 THBS1 TGFBR1 TGFBR1 E2F5 E2F5 ZFYVE9 ZFYVE9 GREM1 GREM1 AMH AMH IFNG IFNG PPP2CA PPP2CA GDF7 GDF7 ACVR2B ACVR2B BMPR1B BMPR1B NOG NOG SMAD4 SMAD4 BMP6 BMP6 SMAD7 SMAD7 PPP2R1B PPP2R1B INHBE INHBE SMAD2 SMAD2 TFDP1 TFDP1 INHBA INHBA INHBC INHBC SMAD1 SMAD1 BMPR2 BMPR2 CHRD CHRD THSD4 THSD4 RGMB RGMB CUL1 CUL1 BMP2 BMP2 INHBB INHBB BAMBI BAMBI TGFB2 TGFB2 HAMP HAMP SKP1 SKP1 BMP5 BMP5 ZFYVE16 ZFYVE16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
LOC103090703S-phase kinase-associated protein 1-like; Belongs to the SKP1 family. (162 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
NEO1Neogenin. (1050 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
GDF5Growth/differentiation factor 5. (499 aa)
RGMARepulsive guidance molecule A isoform X1. (454 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (720 aa)
FMODFibromodulin. (376 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
LOC103079743Homeobox protein. (212 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1713 aa)
PITX2Homeobox protein. (325 aa)
CREBBPCREB-binding protein isoform X1. (2429 aa)
LOC103079191Bone morphogenetic protein 8B-like. (180 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (105 aa)
EP300Histone acetyltransferase p300. (2420 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
GDF6Growth/differentiation factor 6. (461 aa)
LEFTY2Left-right determination factor. (367 aa)
LOC103089261Bone morphogenetic protein 8B-like. (403 aa)
BMP8BBone morphogenetic protein 8B. (403 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
LOC103073398Left-right determination factor. (367 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NODALNodal homolog. (349 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (131 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
TGIF1Homeobox protein TGIF1 isoform X1. (341 aa)
FBN1Fibrillin-1. (2776 aa)
LOC103082213Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like isoform X1. (589 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
HFE2Hemojuvelin. (424 aa)
FSTFollistatin isoform X1. (344 aa)
E2F4Transcription factor E2F4. (406 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1 isoform X1. (214 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
THBS1Thrombospondin-1. (1170 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
E2F5Transcription factor E2F5. (346 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1420 aa)
GREM1Gremlin. (184 aa)
AMHMuellerian-inhibiting factor. (558 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
GDF7Growth/differentiation factor 7. (457 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
BMP6Bone morphogenetic protein 6. (495 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (644 aa)
INHBEInhibin beta E chain. (351 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TFDP1Transcription factor. (410 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (430 aa)
INHBCInhibin beta C chain. (352 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (958 aa)
THSD4LOW QUALITY PROTEIN: thrombospondin type-1 domain-containing protein 4. (1017 aa)
RGMBRGM domain family member B. (482 aa)
CUL1Cullin-1 isoform X1; Belongs to the cullin family. (776 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
INHBBInhibin beta B chain. (511 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HAMPHepcidin. (81 aa)
SKP1LOW QUALITY PROTEIN: S-phase kinase-associated protein 1; Belongs to the SKP1 family. (166 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (454 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16 isoform X1. (1546 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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