STRINGSTRING
RHOA RHOA MYLK2 MYLK2 P2RY12 P2RY12 SYK SYK SRC SRC LCP2 LCP2 ADCY2 ADCY2 ACTB ACTB ORAI1 ORAI1 PPP1CC PPP1CC ITPR2 ITPR2 ADCY1 ADCY1 ADCY4 ADCY4 PRKG2 PRKG2 GNAS GNAS ADCY8 ADCY8 PRKCZ PRKCZ PPP1R12A PPP1R12A LOC103075329 LOC103075329 MAPK1 MAPK1 LOC103082455 LOC103082455 FGA FGA RAP1A RAP1A LOC103069249 LOC103069249 ADCY5 ADCY5 GNAI3 GNAI3 LOC103085385 LOC103085385 PLCB4 PLCB4 MYLK4 MYLK4 MYLK MYLK FGB FGB PPP1CA PPP1CA FYN FYN PLCB1 PLCB1 PIK3R3 PIK3R3 MYLK3 MYLK3 ADCY6 ADCY6 LOC103068503 LOC103068503 ARHGEF12 ARHGEF12 PIK3CD PIK3CD PLA2G4A PLA2G4A MAPK11 MAPK11 PLCG2 PLCG2 MAPK3 MAPK3 ITGA2B ITGA2B ADCY9 ADCY9 GP5 GP5 ADCY3 ADCY3 ITPR1 ITPR1 PIK3CG PIK3CG F2 F2 MAPK12 MAPK12 P2RX1 P2RX1 GNA13 GNA13 PIK3R1 PIK3R1 AKT1 AKT1 GUCY1A2 GUCY1A2 ITGA2 ITGA2 PIK3R6 PIK3R6 LOC103088639 LOC103088639 ITGB3 ITGB3 ARHGAP35 ARHGAP35 PTGIR PTGIR TLN1 TLN1 ARHGEF1 ARHGEF1 AKT2 AKT2 LOC103086084 LOC103086084 TLN2 TLN2 MYL12B MYL12B ROCK2 ROCK2 PRKACB PRKACB GNAQ GNAQ GP1BA GP1BA PIK3R5 PIK3R5 PLA2G4F PLA2G4F RASGRP1 RASGRP1 VASP VASP PLA2G4B PLA2G4B PLCB2 PLCB2 TBXA2R TBXA2R ADCY7 ADCY7 LOC103075302 LOC103075302 PLCB3 PLCB3 FERMT3 FERMT3 SNAP23 SNAP23 PIK3R2 PIK3R2 ACTG1 ACTG1 PLA2G4D PLA2G4D GP1BB GP1BB PLA2G4E PLA2G4E AKT3 AKT3 STIM1 STIM1 GUCY1B3 GUCY1B3 ITPR3 ITPR3 RASGRP2 RASGRP2 F2RL3 F2RL3 RAP1B RAP1B F2R F2R LYN LYN GP9 GP9 LOC103071971 LOC103071971 PIK3CB PIK3CB TBXAS1 TBXAS1 PRKCI PRKCI PIK3CA PIK3CA COL3A1 COL3A1 MAPK14 MAPK14 GNAI1 GNAI1 MAPK13 MAPK13 GP6 GP6 GNAI2 GNAI2 PTGS1 PTGS1 PRKACA PRKACA FCER1G FCER1G VWF VWF BTK BTK PRKG1 PRKG1 VAMP8 VAMP8 LOC103088976 LOC103088976 NOS3 NOS3 APBB1IP APBB1IP PPP1CB PPP1CB ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOATransforming protein RhoA isoform X1. (221 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (597 aa)
P2RY12LOW QUALITY PROTEIN: P2Y purinoceptor 12. (336 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
SRCTyrosine-protein kinase. (548 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ORAI1Calcium release-activated calcium channel protein 1. (303 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (943 aa)
LOC103075329P2Y purinoceptor 1-like; Belongs to the G-protein coupled receptor 1 family. (373 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
FGAFibrinogen alpha chain. (605 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
LOC103069249Collagen alpha-2(I) chain-like isoform X3. (1370 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (377 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (1962 aa)
FGBFibrinogen beta chain isoform X1. (488 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
FYNTyrosine-protein kinase. (537 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
LOC103068503LOW QUALITY PROTEIN: fibrinogen gamma-B chain-like. (445 aa)
ARHGEF12LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12. (1563 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
PLA2G4APhospholipase A2. (749 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1035 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GP5Platelet glycoprotein V. (769 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (658 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
LOC103088639Myosin regulatory light polypeptide 9-like isoform X1. (178 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
TLN1LOW QUALITY PROTEIN: talin-1. (2541 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (913 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
LOC103086084LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like. (375 aa)
TLN2Talin-2. (2542 aa)
MYL12BMyosin regulatory light chain 12B isoform X1. (171 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
GP1BAPlatelet glycoprotein Ib alpha chain. (584 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
PLA2G4FPhospholipase A2. (849 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
PLA2G4BPhospholipase A2. (780 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
LOC103075302Guanylate cyclase soluble subunit alpha-1-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
FERMT3Fermitin family homolog 3 isoform X1. (663 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PLA2G4DPhospholipase A2. (818 aa)
GP1BBPlatelet glycoprotein Ib beta chain. (205 aa)
PLA2G4EPhospholipase A2. (883 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
STIM1Stromal interaction molecule 1 isoform X1. (785 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (551 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
RASGRP2RAS guanyl-releasing protein 2 isoform X1. (608 aa)
F2RL3Proteinase-activated receptor 4; Belongs to the G-protein coupled receptor 1 family. (379 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (428 aa)
LYNTyrosine-protein kinase. (516 aa)
GP9Platelet glycoprotein IX. (177 aa)
LOC103071971Collagen alpha-1(I) chain-like. (1463 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
TBXAS1thromboxane-A synthase; Belongs to the cytochrome P450 family. (533 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
COL3A1Collagen alpha-1(III) chain-like. (1462 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
GP6Platelet glycoprotein VI. (365 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
PTGS1Prostaglandin G/H synthase 1 isoform X1. (622 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (87 aa)
VWFVon Willebrand factor. (2780 aa)
BTKTyrosine-protein kinase. (659 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
VAMP8Vesicle-associated membrane protein 8. (99 aa)
LOC103088976Ras-related protein Rap-1b-like isoform X1. (165 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
APBB1IPAmyloid beta A4 precursor protein-binding family B member 1-interacting protein-like. (660 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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