STRINGSTRING
RHOA RHOA MAPK8 MAPK8 IL1B IL1B PRKCD PRKCD KRAS KRAS SYK SYK SRC SRC NFATC4 NFATC4 CALML4 CALML4 NFATC2 NFATC2 ITPR2 ITPR2 EGR2 EGR2 IL6 IL6 NFATC1 NFATC1 IRF9 IRF9 MAPK1 MAPK1 PLK3 PLK3 PTGS2 PTGS2 CALML6 CALML6 MALT1 MALT1 PIK3R3 PIK3R3 EGR3 EGR3 ARHGEF12 ARHGEF12 PYCARD PYCARD PPP3CC PPP3CC PIK3CD PIK3CD MAPK11 MAPK11 KSR1 KSR1 PLCG2 PLCG2 MAPK3 MAPK3 IKBKB IKBKB ITPR1 ITPR1 IL12A IL12A PPP3CB PPP3CB MAPK12 MAPK12 PPP3R2 PPP3R2 PIK3R1 PIK3R1 AKT1 AKT1 BCL10 BCL10 MAP3K14 MAP3K14 AKT2 AKT2 IKBKG IKBKG CARD9 CARD9 CYLD CYLD CALM3 CALM3 BCL3 BCL3 TNF TNF RELB RELB LOC103078860 LOC103078860 RELA RELA LOC103080868 LOC103080868 PIK3R2 PIK3R2 RRAS2 RRAS2 JUN JUN AKT3 AKT3 PAK1 PAK1 ITPR3 ITPR3 LOC103081962 LOC103081962 IRF1 IRF1 MDM2 MDM2 RAF1 RAF1 CBLB CBLB PPP3CA PPP3CA PPP3R1 PPP3R1 NRAS NRAS RRAS RRAS NFKBIA NFKBIA IL2 IL2 MAPK9 MAPK9 MAPK10 MAPK10 NFKB1 NFKB1 LSP1 LSP1 LOC103069117 LOC103069117 LOC103073993 LOC103073993 MRAS MRAS PIK3CB PIK3CB IL12B IL12B LOC103073060 LOC103073060 PIK3CA PIK3CA MAPK14 MAPK14 MAPK13 MAPK13 LOC103074541 LOC103074541 CALML5 CALML5 HRAS HRAS LOC103080261 LOC103080261 CASP8 CASP8 FCER1G FCER1G CCL22 CCL22 IL23A IL23A LOC103080747 LOC103080747 STAT2 STAT2 NFKB2 NFKB2 LOC103076420 LOC103076420 PTPN11 PTPN11 CLEC7A CLEC7A MAPKAPK2 MAPKAPK2 CHUK CHUK IL10 IL10 IKBKE IKBKE CALM1 CALM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOATransforming protein RhoA isoform X1. (221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
KRASGTPase KRas. (188 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
SRCTyrosine-protein kinase. (548 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (919 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (485 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (697 aa)
IRF9Interferon regulatory factor 9. (412 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PTGS2Prostaglandin G/H synthase 2 isoform X2. (604 aa)
CALML6Calmodulin-like protein 6. (190 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (834 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
ARHGEF12LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12. (1563 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (195 aa)
PPP3CCSerine/threonine-protein phosphatase. (583 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
KSR1Kinase suppressor of Ras 1. (757 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (257 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (959 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
CARD9Caspase recruitment domain-containing protein 9. (539 aa)
CYLDLOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (962 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RELBTranscription factor RelB. (564 aa)
LOC103078860Caspase-1-like; Belongs to the peptidase C14A family. (404 aa)
RELATranscription factor p65 isoform X1. (560 aa)
LOC103080868CD209 antigen-like protein 2-like. (258 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (127 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
LOC103081962NACHT, LRR and PYD domains-containing protein 3-like. (1037 aa)
IRF1Interferon regulatory factor. (322 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (983 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
NRASGTPase NRas. (189 aa)
RRASRas-related protein R-Ras. (218 aa)
NFKBIANF-kappa-B inhibitor alpha. (304 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
LSP1Lymphocyte-specific protein 1. (458 aa)
LOC103069117LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-like. (721 aa)
LOC103073993Apoptosis-associated speck-like protein containing a CARD-like. (258 aa)
MRASRas-related protein M-Ras isoform X1. (208 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC103073060Synaptopodin 2-like protein-like. (392 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
CALML5Calmodulin-like protein 5. (140 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC103080261C-C motif chemokine. (201 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (87 aa)
CCL22C-C motif chemokine. (93 aa)
IL23AInterleukin-23 subunit alpha. (187 aa)
LOC103080747C-type lectin domain family 4 member E-like. (212 aa)
STAT2Signal transducer and activator of transcription. (895 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (899 aa)
LOC103076420C-type lectin domain family 1 member B-like. (226 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CLEC7AC-type lectin domain family 7 member A isoform X1. (244 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (747 aa)
IL10Interleukin-10. (178 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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