STRINGSTRING
RHOA RHOA MAPK8 MAPK8 SOS2 SOS2 PTPRC PTPRC KRAS KRAS LCP2 LCP2 SOS1 SOS1 NFATC2 NFATC2 ITK ITK NFATC1 NFATC1 LOC103073818 LOC103073818 VAV3 VAV3 GSK3B GSK3B MAP2K1 MAP2K1 TEC TEC MAPK1 MAPK1 MALT1 MALT1 FYN FYN PIK3R3 PIK3R3 VAV2 VAV2 PPP3CC PPP3CC PIK3CD PIK3CD MAPK11 MAPK11 MAP3K7 MAP3K7 PAK7 PAK7 MAPK3 MAPK3 CD40LG CD40LG LAT LAT CD28 CD28 IKBKB IKBKB PDPK1 PDPK1 PPP3CB PPP3CB MAPK12 MAPK12 CD3E CD3E GRAP2 GRAP2 CTLA4 CTLA4 CD3D CD3D PPP3R2 PPP3R2 GRB2 GRB2 NCK2 NCK2 PIK3R1 PIK3R1 AKT1 AKT1 ICOS ICOS BCL10 BCL10 MAP3K14 MAP3K14 LOC103072956 LOC103072956 CD247 CD247 AKT2 AKT2 CD3G CD3G IKBKG IKBKG NCK1 NCK1 RASGRP1 RASGRP1 NFKBIE NFKBIE MAP2K7 MAP2K7 TNF TNF FOS FOS CDC42 CDC42 MAP2K2 MAP2K2 RELA RELA PIK3R2 PIK3R2 PAK6 PAK6 JUN JUN AKT3 AKT3 VAV1 VAV1 PAK1 PAK1 IL4 IL4 RAF1 RAF1 IFNG IFNG CSF2 CSF2 IL5 IL5 CBLB CBLB PPP3CA PPP3CA PPP3R1 PPP3R1 NRAS NRAS PAK4 PAK4 PLCG1 PLCG1 NFKBIA NFKBIA IL2 IL2 MAPK9 MAPK9 MAPK10 MAPK10 NFKBIB NFKBIB PAK2 PAK2 NFKB1 NFKB1 PRKCQ PRKCQ PIK3CB PIK3CB PAK3 PAK3 PIK3CA PIK3CA MAPK14 MAPK14 MAPK13 MAPK13 DLG1 DLG1 CD8A CD8A HRAS HRAS CD8B CD8B CARD11 CARD11 CDK4 CDK4 CD4 CD4 LCK LCK ZAP70 ZAP70 CHUK CHUK PTPN6 PTPN6 MAP3K8 MAP3K8 IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOATransforming protein RhoA isoform X1. (221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1121 aa)
KRASGTPase KRas. (188 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (919 aa)
ITKTyrosine-protein kinase. (620 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (697 aa)
LOC103073818Programmed cell death protein 1-like. (262 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
TECTyrosine-protein kinase. (633 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (834 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
PPP3CCSerine/threonine-protein phosphatase. (583 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PAK7Non-specific serine/threonine protein kinase. (719 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
LATLinker for activation of T-cells family member 1. (260 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (197 aa)
GRAP2GRB2-related adapter protein 2. (317 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
CD3DT-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
NCK2Cytoplasmic protein. (376 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ICOSInducible T-cell costimulator. (318 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (959 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (152 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (182 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
NCK1Cytoplasmic protein. (377 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
NFKBIENF-kappa-B inhibitor epsilon. (426 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
PAK6Non-specific serine/threonine protein kinase. (675 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VAV1Proto-oncogene vav isoform X1. (844 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (983 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
NRASGTPase NRas. (189 aa)
PAK4Non-specific serine/threonine protein kinase. (591 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
NFKBIANF-kappa-B inhibitor alpha. (304 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (579 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain. (239 aa)
HRASGTPase HRas isoform X1. (189 aa)
CD8BT-cell surface glycoprotein CD8 beta chain isoform X1. (210 aa)
CARD11Caspase recruitment domain-containing protein 11 isoform X2. (1147 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CD4T-cell surface glycoprotein CD4. (454 aa)
LCKTyrosine-protein kinase. (520 aa)
ZAP70Tyrosine-protein kinase. (635 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (747 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
IL10Interleukin-10. (178 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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