STRINGSTRING
RHOA RHOA CLDN23 CLDN23 MYL7 MYL7 ACTB ACTB LOC103080445 LOC103080445 MLLT4 MLLT4 MSN MSN PXN PXN ITK ITK MYL9 MYL9 VAV3 VAV3 VCAM1 VCAM1 RAC1 RAC1 PRKCB PRKCB LOC103082455 LOC103082455 RAP1A RAP1A CLDN20 CLDN20 GNAI3 GNAI3 ARHGAP5 ARHGAP5 MMP9 MMP9 JAM3 JAM3 LOC103078741 LOC103078741 CXCR4 CXCR4 NCF2 NCF2 LOC103088449 LOC103088449 PIK3R3 PIK3R3 VAV2 VAV2 PIK3CD PIK3CD TXK TXK CD99L2 CD99L2 NCF4 NCF4 MAPK11 MAPK11 PLCG2 PLCG2 CLDN19 CLDN19 RHOH RHOH ACTN1 ACTN1 ITGAM ITGAM ITGB2 ITGB2 ITGAL ITGAL PRKCA PRKCA CLDN6 CLDN6 CLDN9 CLDN9 MAPK12 MAPK12 RAC2 RAC2 THY1 THY1 PIK3R1 PIK3R1 CDH5 CDH5 CLDN17 CLDN17 CLDN1 CLDN1 CTNND1 CTNND1 LOC103088639 LOC103088639 CLDN2 CLDN2 PECAM1 PECAM1 ARHGAP35 ARHGAP35 CTNNA3 CTNNA3 MYL12B MYL12B ROCK2 ROCK2 OCLN OCLN CLDN8 CLDN8 CLDN7 CLDN7 VASP VASP ICAM1 ICAM1 MMP2 MMP2 RAPGEF4 RAPGEF4 PRKCG PRKCG CDC42 CDC42 CTNNA1 CTNNA1 SIPA1 SIPA1 CLDN5 CLDN5 PIK3R2 PIK3R2 ACTG1 ACTG1 XG XG VAV1 VAV1 RAP1B RAP1B ITGA4 ITGA4 EZR EZR BCAR1 BCAR1 CLDN11 CLDN11 PLCG1 PLCG1 CTNNA2 CTNNA2 ESAM ESAM RAPGEF3 RAPGEF3 PTK2B PTK2B CLDN16 CLDN16 PIK3CB PIK3CB CTNNB1 CTNNB1 PTK2 PTK2 CLDN24 CLDN24 PIK3CA PIK3CA MAPK14 MAPK14 GNAI1 GNAI1 MAPK13 MAPK13 LOC103071897 LOC103071897 MYL2 MYL2 GNAI2 GNAI2 LOC103090543 LOC103090543 F11R F11R JAM2 JAM2 MYL10 MYL10 CLDN15 CLDN15 CLDN4 CLDN4 VCL VCL CLDN14 CLDN14 CLDN10 CLDN10 NCF1 NCF1 CLDN3 CLDN3 PTPN11 PTPN11 ACTN4 ACTN4 LOC103088976 LOC103088976 RASSF5 RASSF5 CLDN25 CLDN25 ITGB1 ITGB1 CLDN22 CLDN22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOATransforming protein RhoA isoform X1. (221 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (293 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (148 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LOC103080445Catenin alpha-2-like isoform X1. (585 aa)
MLLT4LOW QUALITY PROTEIN: afadin. (1714 aa)
MSNMoesin. (577 aa)
PXNPaxillin-like isoform X1; Belongs to the paxillin family. (591 aa)
ITKTyrosine-protein kinase. (620 aa)
MYL9Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
VCAM1Vascular cell adhesion protein 1 isoform X1. (739 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
JAM3Junctional adhesion molecule C. (383 aa)
LOC103078741Cytochrome b-245 heavy chain-like isoform X1. (569 aa)
CXCR4c-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
LOC103088449Myosin regulatory light chain 2, skeletal muscle isoform type 2-like. (170 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
TXKTyrosine-protein kinase. (525 aa)
CD99L2CD99 antigen-like protein 2 isoform X1. (266 aa)
NCF4Neutrophil cytosol factor 4. (339 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
ACTN1Alpha-actinin-1 isoform X1. (914 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
ITGB2Integrin beta. (769 aa)
ITGALIntegrin alpha-L isoform X1; Belongs to the integrin alpha chain family. (1167 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CTNND1Catenin delta-1 isoform X1. (978 aa)
LOC103088639Myosin regulatory light polypeptide 9-like isoform X1. (178 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
PECAM1Platelet endothelial cell adhesion molecule. (779 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
CTNNA3Catenin alpha-3. (702 aa)
MYL12BMyosin regulatory light chain 12B isoform X1. (171 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (527 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
MMP272 kDa type IV collagenase. (584 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
CTNNA1Catenin alpha-1 isoform X1. (906 aa)
SIPA1Signal-induced proliferation-associated protein 1. (1040 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
XGLOW QUALITY PROTEIN: glycoprotein Xg. (197 aa)
VAV1Proto-oncogene vav isoform X1. (844 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
EZREzrin isoform X1. (586 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X1. (867 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CTNNA2Catenin alpha-2-like. (452 aa)
ESAMEndothelial cell-selective adhesion molecule isoform X1. (396 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC103071897Stromal cell-derived factor 1-like isoform X2; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
LOC103090543Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (192 aa)
F11RJunctional adhesion molecule A. (299 aa)
JAM2Junctional adhesion molecule B. (298 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
VCLVinculin isoform X1. (1134 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
NCF1Neutrophil cytosol factor 1. (393 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ACTN4Alpha-actinin-4 isoform X1. (933 aa)
LOC103088976Ras-related protein Rap-1b-like isoform X1. (165 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (420 aa)
CLDN25LOW QUALITY PROTEIN: claudin 25. (225 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
CLDN22LOW QUALITY PROTEIN: claudin 22. (235 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (20%) [HD]