STRINGSTRING
KRAS KRAS HTR1A HTR1A GNG2 GNG2 ITPR2 ITPR2 ALOX5 ALOX5 TRPC1 TRPC1 HTR4 HTR4 CACNA1D CACNA1D DDC DDC GNAS GNAS MAP2K1 MAP2K1 TPH2 TPH2 PRKCB PRKCB HTR2C HTR2C MAPK1 MAPK1 PTGS2 PTGS2 KCNN2 KCNN2 GNB1 GNB1 ADCY5 ADCY5 GNAI3 GNAI3 LOC103085385 LOC103085385 PLCB4 PLCB4 GNG10 GNG10 GNG11 GNG11 PLCB1 PLCB1 ARAF ARAF LOC103080373 LOC103080373 CACNA1F CACNA1F PLA2G4A PLA2G4A HTR1F HTR1F LOC103081664 LOC103081664 SLC6A4 SLC6A4 MAPK3 MAPK3 HTR3B HTR3B GNG4 GNG4 HTR3A HTR3A PRKCA PRKCA ITPR1 ITPR1 GNG13 GNG13 CACNA1S CACNA1S MAOB MAOB HTR5A HTR5A ALOX15 ALOX15 MAOA MAOA GABRB3 GABRB3 LOC103081045 LOC103081045 CACNA1B CACNA1B HTR1B HTR1B ALOX15B ALOX15B HTR6 HTR6 PRKACB PRKACB GNG8 GNG8 GNAQ GNAQ ALOX12 ALOX12 PLA2G4F PLA2G4F TPH1 TPH1 PRKCG PRKCG PLA2G4B PLA2G4B PLCB2 PLCB2 GNB5 GNB5 KCNJ9 KCNJ9 PLCB3 PLCB3 PLA2G4D PLA2G4D PLA2G4E PLA2G4E HTR2B HTR2B ITPR3 ITPR3 RAF1 RAF1 GNG3 GNG3 NRAS NRAS LOC103072875 LOC103072875 KCNJ5 KCNJ5 HTR7 HTR7 RAPGEF3 RAPGEF3 GABRB2 GABRB2 HTR2A HTR2A DUSP1 DUSP1 APP APP LOC103075492 LOC103075492 LOC103089724 LOC103089724 KCNJ3 KCNJ3 GNAI1 GNAI1 HTR1E HTR1E HRAS HRAS GNAI2 GNAI2 PTGS1 PTGS1 LOC103069500 LOC103069500 CASP3 CASP3 BRAF BRAF GNB2 GNB2 GNB4 GNB4 PRKACA PRKACA GNB3 GNB3 CACNA1C CACNA1C SLC18A2 SLC18A2 KCNJ6 KCNJ6 CACNA1A CACNA1A LOC103084494 LOC103084494 SLC18A1 SLC18A1 HTR1D HTR1D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASGTPase KRas. (188 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
TRPC1Short transient receptor potential channel 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
HTR45-hydroxytryptamine receptor 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (402 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
DDCaromatic-L-amino-acid decarboxylase. (315 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
TPH2Tryptophan 5-hydroxylase 2. (491 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
PTGS2Prostaglandin G/H synthase 2 isoform X2. (604 aa)
KCNN2Small conductance calcium-activated potassium channel protein 2 isoform X1. (842 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1. (340 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
LOC103080373Gamma-aminobutyric acid receptor subunit beta-1-like isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (313 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1976 aa)
PLA2G4APhospholipase A2. (749 aa)
HTR1F5-hydroxytryptamine receptor 1F. (365 aa)
LOC103081664Potassium voltage-gated channel subfamily D member 2-like; Belongs to the potassium channel family. (372 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (458 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
MAOBAmine oxidase. (520 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
ALOX15LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase. (663 aa)
MAOAAmine oxidase. (527 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (473 aa)
LOC103081045LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like. (370 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2261 aa)
HTR1B5-hydroxytryptamine receptor 1B. (399 aa)
ALOX15BArachidonate 15-lipoxygenase B. (659 aa)
HTR6LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (80 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
PLA2G4FPhospholipase A2. (849 aa)
TPH1Tryptophan 5-hydroxylase 1. (444 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PLA2G4BPhospholipase A2. (780 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (395 aa)
KCNJ9LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 3. (469 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PLA2G4DPhospholipase A2. (818 aa)
PLA2G4EPhospholipase A2. (883 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NRASGTPase NRas. (189 aa)
LOC103072875Cytochrome P450 2J2-like; Belongs to the cytochrome P450 family. (509 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4 isoform X1. (419 aa)
HTR75-hydroxytryptamine receptor 7 isoform X1; Belongs to the G-protein coupled receptor 1 family. (448 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
GABRB2Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
LOC103075492Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC103089724Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
HRASGTPase HRas isoform X1. (189 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
PTGS1Prostaglandin G/H synthase 1 isoform X1. (622 aa)
LOC103069500Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (76 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2112 aa)
SLC18A2Synaptic vesicular amine transporter. (517 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2295 aa)
LOC103084494Cytochrome P450 2C23-like; Belongs to the cytochrome P450 family. (504 aa)
SLC18A1Chromaffin granule amine transporter. (523 aa)
HTR1DLOW QUALITY PROTEIN: 5-hydroxytryptamine (Serotonin) receptor 1D, G protein-coupled. (377 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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