STRINGSTRING
RHOA RHOA MYLK2 MYLK2 CAMK2B CAMK2B KRAS KRAS SRC SRC NFATC4 NFATC4 LOC103077121 LOC103077121 ADCY2 ADCY2 ACTB ACTB CALML4 CALML4 PRKAG3 PRKAG3 PRKAB2 PRKAB2 CACNB2 CACNB2 PPP1CC PPP1CC NFATC2 NFATC2 ITPR2 ITPR2 MAP2K5 MAP2K5 RCAN1 RCAN1 ADCY1 ADCY1 KCNJ12 KCNJ12 CACNG2 CACNG2 CACNA1D CACNA1D MYL9 MYL9 CACNA2D3 CACNA2D3 ADCY4 ADCY4 NFATC1 NFATC1 CACNG3 CACNG3 GNAS GNAS ADCY8 ADCY8 MAP2K1 MAP2K1 CAMK2A CAMK2A EEF2K EEF2K PRKCB PRKCB MAPK7 MAPK7 PPP1R12A PPP1R12A MAPK1 MAPK1 LOC103082455 LOC103082455 PTGS2 PTGS2 CAMKK2 CAMKK2 CALML6 CALML6 ADCY5 ADCY5 GNAI3 GNAI3 LOC103085385 LOC103085385 PLCB4 PLCB4 MYLK4 MYLK4 MYLK MYLK CACNB3 CACNB3 PRKAG1 PRKAG1 PPP1CA PPP1CA PLCB1 PLCB1 MYLK3 MYLK3 ADCY6 ADCY6 CAMK4 CAMK4 PPP3CC PPP3CC ELK1 ELK1 CACNA1F CACNA1F RYR2 RYR2 PLA2G4A PLA2G4A CAMK1G CAMK1G CACNA2D2 CACNA2D2 MAPK3 MAPK3 TRPM2 TRPM2 CAMK2D CAMK2D CAMK1D CAMK1D ADCY9 ADCY9 PRKCA PRKCA ADCY3 ADCY3 ITPR1 ITPR1 CACNG1 CACNG1 PIK3CG PIK3CG CACNA1S CACNA1S NPR2 NPR2 PPP3CB PPP3CB KCNJ4 KCNJ4 PPP1R12B PPP1R12B PPP3R2 PPP3R2 KCNJ2 KCNJ2 GUCY1A2 GUCY1A2 LOC103072956 LOC103072956 CACNG5 CACNG5 PIK3R6 PIK3R6 LOC103086084 LOC103086084 CACNG7 CACNG7 CACNG6 CACNG6 ROCK2 ROCK2 PRKACB PRKACB GNAQ GNAQ PIK3R5 PIK3R5 PLA2G4F PLA2G4F CACNG8 CACNG8 NPR1 NPR1 CALM3 CALM3 FOS FOS PRKCG PRKCG PLA2G4B PLA2G4B PLCB2 PLCB2 MAP2K2 MAP2K2 ADCY7 ADCY7 LOC103075302 LOC103075302 KCNJ9 KCNJ9 PLCB3 PLCB3 ACTG1 ACTG1 PLA2G4D PLA2G4D JUN JUN PLA2G4E PLA2G4E EEF2 EEF2 GUCY1B3 GUCY1B3 ITPR3 ITPR3 RAF1 RAF1 EGFR EGFR PPP3CA PPP3CA PPP3R1 PPP3R1 CACNB4 CACNB4 NRAS NRAS RYR3 RYR3 PRKAA2 PRKAA2 KCNJ5 KCNJ5 PRKAB1 PRKAB1 NPPA NPPA CD38 CD38 KCNJ14 KCNJ14 OXTR OXTR CACNB1 CACNB1 KCNJ3 KCNJ3 GNAI1 GNAI1 MEF2C MEF2C OXT OXT MYL6 MYL6 LOC103074541 LOC103074541 CCND1 CCND1 CALML5 CALML5 HRAS HRAS MYL6B MYL6B RGS2 RGS2 GNAI2 GNAI2 CAMK2G CAMK2G PRKACA PRKACA CACNA2D1 CACNA2D1 CDKN1A CDKN1A CACNA1C CACNA1C CACNA2D4 CACNA2D4 PRKAG2 PRKAG2 PPP1R12C PPP1R12C RYR1 RYR1 KCNJ6 KCNJ6 PRKAA1 PRKAA1 NOS3 NOS3 PPP1CB PPP1CB CALM1 CALM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOATransforming protein RhoA isoform X1. (221 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (597 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
KRASGTPase KRas. (188 aa)
SRCTyrosine-protein kinase. (548 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
LOC103077121Oxytocin-neurophysin 1-like. (110 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
ACTBActin, cytoplasmic 1. (375 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X3. (482 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (651 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (919 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5-like. (282 aa)
RCAN1Calcipressin-1. (226 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12. (427 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
MYL9Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3. (810 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (697 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
EEF2KEukaryotic elongation factor 2 kinase. (722 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (774 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (943 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PTGS2Prostaglandin G/H synthase 2 isoform X2. (604 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (580 aa)
CALML6Calmodulin-like protein 6. (190 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (377 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (1962 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X2. (336 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
PPP3CCSerine/threonine-protein phosphatase. (583 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (444 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1976 aa)
RYR2Ryanodine receptor 2-like. (4986 aa)
PLA2G4APhospholipase A2. (749 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G isoform X2; Belongs to the protein kinase superfamily. (476 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1. (1153 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
CAMK2DLOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta. (536 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D; Belongs to the protein kinase superfamily. (385 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
NPR2Guanylate cyclase. (1052 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
KCNJ4Inward rectifier potassium channel 4. (445 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (890 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
KCNJ2Inward rectifier potassium channel 2. (427 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (658 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
LOC103086084LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like. (375 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit. (225 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
PLA2G4FPhospholipase A2. (849 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (448 aa)
NPR1Guanylate cyclase. (1058 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PLA2G4BPhospholipase A2. (780 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
LOC103075302Guanylate cyclase soluble subunit alpha-1-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
KCNJ9LOW QUALITY PROTEIN: G protein-activated inward rectifier potassium channel 3. (469 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PLA2G4DPhospholipase A2. (818 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
PLA2G4EPhospholipase A2. (883 aa)
EEF2Elongation factor 2. (858 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (551 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
NRASGTPase NRas. (189 aa)
RYR3Ryanodine receptor 3. (4869 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4 isoform X1. (419 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
NPPANatriuretic peptides A. (152 aa)
CD38ADP-ribosyl cyclase 1. (291 aa)
KCNJ14ATP-sensitive inward rectifier potassium channel 14. (434 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
CACNB1LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1. (678 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
OXTOxytocin-neurophysin 1; Belongs to the vasopressin/oxytocin family. (125 aa)
MYL6Myosin light polypeptide 6 isoform X1. (151 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CALML5Calmodulin-like protein 5. (140 aa)
HRASGTPase HRas isoform X1. (189 aa)
MYL6BMyosin light chain 6B. (213 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (672 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1. (959 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2112 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1153 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (784 aa)
RYR1Ryanodine receptor 1 isoform X2. (5032 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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