STRINGSTRING
MAPK8 MAPK8 SOS2 SOS2 SHC3 SHC3 KRAS KRAS SRC SRC ADCY2 ADCY2 SOS1 SOS1 EDN1 EDN1 GNG2 GNG2 RXFP1 RXFP1 ADCY1 ADCY1 ADCY4 ADCY4 RXFP2 RXFP2 GNAS GNAS MMP13 MMP13 ADCY8 ADCY8 MAP2K1 MAP2K1 PRKCZ PRKCZ VEGFC VEGFC MAPK1 MAPK1 MMP1 MMP1 LOC103069249 LOC103069249 GNB1 GNB1 ADCY5 ADCY5 GNAI3 GNAI3 LOC103085385 LOC103085385 PLCB4 PLCB4 MMP9 MMP9 GNG10 GNG10 GNG11 GNG11 PLCB1 PLCB1 PIK3R3 PIK3R3 ADCY6 ADCY6 NOS2 NOS2 ATF2 ATF2 PIK3CD PIK3CD ATF4 ATF4 MAPK11 MAPK11 MAPK3 MAPK3 GNG4 GNG4 ADCY9 ADCY9 PRKCA PRKCA COL4A1 COL4A1 LOC103077353 LOC103077353 ADCY3 ADCY3 SHC4 SHC4 GNG13 GNG13 CREB3 CREB3 MAPK12 MAPK12 ARRB1 ARRB1 GRB2 GRB2 COL4A2 COL4A2 PIK3R1 PIK3R1 AKT1 AKT1 CREB3L1 CREB3L1 MAP2K4 MAP2K4 LOC103072956 LOC103072956 SHC1 SHC1 NOS1 NOS1 TGFBR2 TGFBR2 AKT2 AKT2 ARRB2 ARRB2 PRKACB PRKACB GNG8 GNG8 WDR78 WDR78 CREB3L4 CREB3L4 VEGFA VEGFA MAP2K7 MAP2K7 MMP2 MMP2 ATF6B ATF6B INSL3 INSL3 TGFB1 TGFB1 FOS FOS PLCB2 PLCB2 GNA15 GNA15 TGFBR1 TGFBR1 SHC2 SHC2 MAP2K2 MAP2K2 ADCY7 ADCY7 GNB5 GNB5 RELA RELA PLCB3 PLCB3 PIK3R2 PIK3R2 JUN JUN CREB3L3 CREB3L3 AKT3 AKT3 VEGFB VEGFB RAF1 RAF1 EGFR EGFR GNG3 GNG3 NRAS NRAS COL4A6 COL4A6 NFKBIA NFKBIA MAPK9 MAPK9 MAPK10 MAPK10 COL4A5 COL4A5 NFKB1 NFKB1 CREB5 CREB5 LOC103071971 LOC103071971 FIGF FIGF PIK3CB PIK3CB LOC103075492 LOC103075492 PIK3CA PIK3CA COL3A1 COL3A1 LOC103089724 LOC103089724 MAPK14 MAPK14 GNAI1 GNAI1 MAPK13 MAPK13 CREB3L2 CREB3L2 SMAD2 SMAD2 COL4A4 COL4A4 EDNRB EDNRB HRAS HRAS GNAI2 GNAI2 LOC103069500 LOC103069500 GNB2 GNB2 GNB4 GNB4 RXFP3 RXFP3 PRKACA PRKACA GNB3 GNB3 RLN3 RLN3 COL4A3 COL4A3 CREB1 CREB1 NOS3 NOS3 LOC103089676 LOC103089676 ACTA2 ACTA2 RXFP4 RXFP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
KRASGTPase KRas. (188 aa)
SRCTyrosine-protein kinase. (548 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
EDN1Endothelin-1. (202 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
RXFP1Relaxin receptor 1 isoform X1. (758 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
RXFP2LOW QUALITY PROTEIN: relaxin receptor 2. (737 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
MMP13Collagenase 3. (471 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
MMP1Interstitial collagenase. (470 aa)
LOC103069249Collagen alpha-2(I) chain-like isoform X3. (1370 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1. (340 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
COL4A1Collagen alpha-1(IV) chain. (1668 aa)
LOC103077353Prorelaxin-like. (183 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (376 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ARRB1Beta-arrestin-1. (418 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
COL4A2Collagen alpha-2(IV) chain. (1671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1427 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
ARRB2Beta-arrestin-2 isoform X1. (421 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (80 aa)
WDR78WD repeat-containing protein 78-like. (419 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (426 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
MMP272 kDa type IV collagenase. (584 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (709 aa)
INSL3Insulin-like 3. (133 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (395 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2. (458 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NRASGTPase NRas. (189 aa)
COL4A6Collagen alpha-6(IV) chain. (1688 aa)
NFKBIANF-kappa-B inhibitor alpha. (304 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
COL4A5Collagen alpha-5(IV) chain isoform X2. (1694 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
LOC103071971Collagen alpha-1(I) chain-like. (1463 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LOC103075492Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
COL3A1Collagen alpha-1(III) chain-like. (1462 aa)
LOC103089724Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
EDNRBEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
HRASGTPase HRas isoform X1. (189 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
LOC103069500Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (76 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
RXFP3LOW QUALITY PROTEIN: relaxin-3 receptor 1. (598 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
RLN3LOW QUALITY PROTEIN: relaxin-3. (174 aa)
COL4A3Collagen alpha-3(IV) chain. (1681 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
LOC103089676Relaxin-3 receptor 1-like. (221 aa)
ACTA2Actin, aortic smooth muscle isoform X1. (377 aa)
RXFP4LOW QUALITY PROTEIN: relaxin/insulin-like family peptide receptor 4. (369 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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