STRINGSTRING
AGTR1 AGTR1 MAPK8 MAPK8 IL1B IL1B PRKCD PRKCD KRAS KRAS PLCD4 PLCD4 STAT5B STAT5B EDN1 EDN1 IL1A IL1A SMAD3 SMAD3 STAT5A STAT5A STAT3 STAT3 IL6 IL6 NFATC1 NFATC1 VCAM1 VCAM1 AGT AGT RAC1 RAC1 PRKCZ PRKCZ PRKCB PRKCB VEGFC VEGFC MAPK1 MAPK1 LOC103069249 LOC103069249 PLCB4 PLCB4 LOC103078741 LOC103078741 PLCB1 PLCB1 PIK3R3 PIK3R3 JAK2 JAK2 PIK3CD PIK3CD MAPK11 MAPK11 PLCG2 PLCG2 MAPK3 MAPK3 PLCD3 PLCD3 PRKCA PRKCA COL4A1 COL4A1 MAPK12 MAPK12 COL4A2 COL4A2 PIK3R1 PIK3R1 AKT1 AKT1 SELE SELE TGFBR2 TGFBR2 CCL2 CCL2 AKT2 AKT2 FN1 FN1 AGER AGER TGFB3 TGFB3 THBD THBD VEGFA VEGFA ICAM1 ICAM1 MMP2 MMP2 TNF TNF TGFB1 TGFB1 PRKCE PRKCE CDC42 CDC42 PLCB2 PLCB2 TGFBR1 TGFBR1 RELA RELA PLCB3 PLCB3 PIK3R2 PIK3R2 JUN JUN AKT3 AKT3 EGR1 EGR1 PLCD1 PLCD1 VEGFB VEGFB BAX BAX NOX4 NOX4 NRAS NRAS PLCG1 PLCG1 COL4A6 COL4A6 BCL2 BCL2 MAPK9 MAPK9 SMAD4 SMAD4 MAPK10 MAPK10 COL4A5 COL4A5 NFKB1 NFKB1 LOC103069117 LOC103069117 LOC103071971 LOC103071971 FIGF FIGF PIK3CB PIK3CB PIK3CA PIK3CA COL3A1 COL3A1 MAPK14 MAPK14 PIM1 PIM1 MAPK13 MAPK13 SMAD2 SMAD2 COL4A4 COL4A4 NOX1 NOX1 CCND1 CCND1 HRAS HRAS DIAPH1 DIAPH1 CASP3 CASP3 IL8 IL8 CDK4 CDK4 COL4A3 COL4A3 F3 F3 SERPINE1 SERPINE1 PLCE1 PLCE1 CDKN1B CDKN1B NOS3 NOS3 TGFB2 TGFB2 FOXO1 FOXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
KRASGTPase KRas. (188 aa)
PLCD4Phosphoinositide phospholipase C. (763 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
EDN1Endothelin-1. (202 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (697 aa)
VCAM1Vascular cell adhesion protein 1 isoform X1. (739 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103069249Collagen alpha-2(I) chain-like isoform X3. (1370 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
LOC103078741Cytochrome b-245 heavy chain-like isoform X1. (569 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
PLCD3Phosphoinositide phospholipase C. (786 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
COL4A1Collagen alpha-1(IV) chain. (1668 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
COL4A2Collagen alpha-2(IV) chain. (1671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SELEE-selectin isoform X1. (554 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
CCL2C-C motif chemokine. (99 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
FN1LOW QUALITY PROTEIN: fibronectin. (2483 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (421 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
THBDThrombomodulin. (584 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
MMP272 kDa type IV collagenase. (584 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. (493 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
PLCD1Phosphoinositide phospholipase C. (721 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
NRASGTPase NRas. (189 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
COL4A6Collagen alpha-6(IV) chain. (1688 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
COL4A5Collagen alpha-5(IV) chain isoform X2. (1694 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
LOC103069117LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-like. (721 aa)
LOC103071971Collagen alpha-1(I) chain-like. (1463 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
COL3A1Collagen alpha-1(III) chain-like. (1462 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (562 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
DIAPH1Protein diaphanous homolog 1 isoform X2. (1236 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
COL4A3Collagen alpha-3(IV) chain. (1681 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FOXO1Forkhead box protein O1. (655 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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