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MAPK8 MAPK8 SOS2 SOS2 SHC3 SHC3 KRAS KRAS ADCY2 ADCY2 STAT5B STAT5B SOS1 SOS1 ITPR2 ITPR2 ADCY1 ADCY1 STAT5A STAT5A IGFBP3 IGFBP3 STAT3 STAT3 CACNA1D CACNA1D ADCY4 ADCY4 LOC103081641 LOC103081641 GHR GHR GHRH GHRH MAP2K3 MAP2K3 GNAS GNAS SST SST ADCY8 ADCY8 GSK3B GSK3B MAP2K1 MAP2K1 PRKCB PRKCB MAPK1 MAPK1 ADCY5 ADCY5 CRKL CRKL GNAI3 GNAI3 IRS2 IRS2 LOC103085385 LOC103085385 PLCB4 PLCB4 PLCB1 PLCB1 PIK3R3 PIK3R3 ADCY6 ADCY6 JAK2 JAK2 ATF2 ATF2 MAP3K1 MAP3K1 CACNA1F CACNA1F PIK3CD PIK3CD CREBBP CREBBP SSTR5 SSTR5 ATF4 ATF4 GHRL GHRL MAPK11 MAPK11 PLCG2 PLCG2 EP300 EP300 IGF1 IGF1 MAPK3 MAPK3 CRK CRK ADCY9 ADCY9 PRKCA PRKCA ADCY3 ADCY3 ITPR1 ITPR1 SHC4 SHC4 IGFALS IGFALS CACNA1S CACNA1S CREB3 CREB3 MAPK12 MAPK12 SSTR3 SSTR3 GRB2 GRB2 SSTR2 SSTR2 PIK3R1 PIK3R1 AKT1 AKT1 CREB3L1 CREB3L1 MAP2K4 MAP2K4 LOC103072956 LOC103072956 SHC1 SHC1 ADCY10 ADCY10 AKT2 AKT2 GH1 GH1 PRKACB PRKACB GNAQ GNAQ CREB3L4 CREB3L4 GNA11 GNA11 LOC103068449 LOC103068449 ATF6B ATF6B FOS FOS PRKCG PRKCG PLCB2 PLCB2 SHC2 SHC2 MAP2K2 MAP2K2 ADCY7 ADCY7 PLCB3 PLCB3 PIK3R2 PIK3R2 SOCS3 SOCS3 CREB3L3 CREB3L3 AKT3 AKT3 ITPR3 ITPR3 RAF1 RAF1 IRS4 IRS4 BCAR1 BCAR1 MTOR MTOR NRAS NRAS PLCG1 PLCG1 SOCS1 SOCS1 MAPK9 MAPK9 MAPK10 MAPK10 SSTR1 SSTR1 LOC103069117 LOC103069117 CREB5 CREB5 PIK3CB PIK3CB PTK2 PTK2 GHSR GHSR PIK3CA PIK3CA MAPK14 MAPK14 GNAI1 GNAI1 MAPK13 MAPK13 CREB3L2 CREB3L2 HRAS HRAS GNAI2 GNAI2 GHRHR GHRHR IRS1 IRS1 PRKACA PRKACA JUNB JUNB CACNA1C CACNA1C SOCS2 SOCS2 POU1F1 POU1F1 CREB1 CREB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
KRASGTPase KRas. (188 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
IGFBP3Insulin-like growth factor-binding protein 3 isoform X2. (299 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2182 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
GHRGrowth hormone receptor isoform X1. (843 aa)
GHRHSomatoliberin isoform X1. (106 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
SSTSomatostatin. (116 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
CRKLCrk-like protein. (303 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1926 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1976 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
CREBBPCREB-binding protein isoform X1. (2429 aa)
SSTR5Somatostatin receptor type 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
GHRLAppetite-regulating hormone isoform X1. (141 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
EP300Histone acetyltransferase p300. (2420 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1141 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
IGFALSInsulin-like growth factor-binding protein complex acid labile subunit. (606 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (376 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SSTR3Somatostatin receptor type 3; Belongs to the G-protein coupled receptor 1 family. (425 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
ADCY10Adenylate cyclase type 10. (1614 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
GH1Somatotropin. (216 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (426 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
LOC103068449Adenylate cyclase type 10-like. (1555 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (709 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2. (458 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X1. (867 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (390 aa)
LOC103069117LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-like. (721 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
HRASGTPase HRas isoform X1. (189 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (452 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
JUNBTranscription factor jun-B. (347 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2112 aa)
SOCS2Suppressor of cytokine signaling 2 isoform X1. (198 aa)
POU1F1POU domain protein. (317 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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